Filtered By:
Source: Stroke
Condition: Hemorrhagic Stroke

This page shows you your search results in order of relevance. This is page number 17.

Order by Relevance | Date

Total 995 results found since Jan 2013.

Permeability Surface of Deep Middle Cerebral Artery Territory on Computed Tomographic Perfusion Predicts Hemorrhagic Transformation After Stroke Clinical Sciences
Conclusions—Increased PS can predict HT of deep MCA territory after recanalization therapy for cerebral proximal large-vessel occlusion. Proximal MCA-M1 complete occlusion and distal internal carotid artery occlusion in conjunction with poor collaterals elevate deep MCA territory PS.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Qiao Li, Xinyi Gao, Zhenwei Yao, Xiaoyuan Feng, Huijin He, Jing Xue, Peiyi Gao, Lumeng Yang, Xin Cheng, Weijian Chen, Yunjun Yang Tags: Angiography, Computerized Tomography (CT), Blood-Brain Barrier, Ischemic Stroke Original Contributions Source Type: research

Normobaric Hyperoxia Reduces Blood Occludin Fragments in Rats and Patients With Acute Ischemic Stroke Basic Sciences
Conclusions—Blood occludin may be a clinically viable biomarker for evaluating BBB damage during ischemia/reperfusion. NBO therapy has the potential to reduce blood occludin, protect BBB, and improve outcome in AIS patients with intravenous tPA thrombolysis.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02974283.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Shuhai Shi, Zhifeng Qi, Qingfeng Ma, Rong Pan, Graham S. Timmins, Yongmei Zhao, Wenjuan Shi, Yunzhou Zhang, Xunming Ji, Ke Jian Liu Tags: Biomarkers, Clinical Studies, Translational Studies, Blood-Brain Barrier, Ischemic Stroke Original Contributions Source Type: research

Statins and the Risk of Intracerebral Hemorrhage in Patients With Previous Ischemic Stroke or Transient Ischemic Attack Clinical Sciences
Conclusions—Statin use was not associated with an increased risk of ICH among patients with a previous history of IS/TIA.
Source: Stroke - November 27, 2017 Category: Neurology Authors: David Gaist, Larry B. Goldstein, Lucia Cea Soriano, Luis Alberto Garcia Rodriguez Tags: Secondary Prevention, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Low Levels of Caveolin-1 Predict Symptomatic Bleeding After Thrombolytic Therapy in Patients With Acute Ischemic Stroke Brief Report
Background and Purpose—Experimental models of cerebral ischemia demonstrate that the decrease in the caveolin-1 membrane protein results in an increase in endothelial permeability. Because this phenomenon is responsible for hemorrhagic transformation (HT) after cerebral ischemia, we aimed to determine whether caveolin-1 levels may predict bleeding after recombinant tissue-type plasminogen activator (r-tPA) administration in patients with acute stroke.Methods—We studied 133 patients with a first hemispheric stroke treated with r-tPA within 4.5 hours of symptom onset. HT was evaluated and classified on cranial computed t...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Mar Castellanos, Cecile van Eendenburg, Carme Gubern, Elisabet Kadar, Gemma Huguet, Josep Puig, Tomas Sobrino, Gerard Blasco, Joaquin Serena, Juan Manuel Sanchez Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Blood-Brain Barrier, Ischemic Stroke Brief Reports Source Type: research

Impact of Transcranial Doppler Ultrasound on Logistics and Outcomes in Stroke Thrombolysis Clinical Sciences
Background and Purpose—Diagnostic transcranial Doppler ultrasound (TCD) is commonly used in patients with acute stroke before or during treatment with intravenous thrombolysis (IVT). We aimed to assess how much TCD delays IVT initiation and whether TCD influences outcomes.Methods—We analyzed data from the SITS-ISTR (Safe Implementation of Thrombolysis in Stroke–International Stroke Thrombolysis Register) collected from December 2002 to December 2011. Outcomes were door-to-needle time, symptomatic intracerebral hemorrhage, functional outcome per the modified Rankin Scale, and mortality at 3 months.Results—In hospita...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Michael V. Mazya, Niaz Ahmed, Elsa Azevedo, Antoni Davalos, Laura Dorado, Michal Karlinski, Svetlana Lorenzano, Jiři Neumann, Danilo Toni, Tiago P. Moreira Tags: Ultrasound, Health Services, Ischemic Stroke Original Contributions Source Type: research

Diabetes Mellitus, Admission Glucose, and Outcomes After Stroke Thrombolysis: A Registry and Systematic Review Clinical Sciences
Conclusions— These results confirm that AGL and history of diabetes mellitus are associated with poor clinical outcome after thrombolysis. AGL may be a surrogate marker of brain infarction severity rather than a causal factor. However, randomized controlled evidences are needed to address the significance of a tight glucose control during thrombolysis on clinical outcome.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Desilles, J.-P., Meseguer, E., Labreuche, J., Lapergue, B., Sirimarco, G., Gonzalez-Valcarcel, J., Lavallee, P., Cabrejo, L., Guidoux, C., Klein, I., Amarenco, P., Mazighi, M. Tags: Acute Stroke Syndromes, Thrombolysis Clinical Sciences Source Type: research

Endoglin Deficiency Impairs Stroke Recovery Basic Sciences
Conclusions— Endoglin deficiency impairs brain injury recovery. Reduced angiogenesis, impaired macrophage homing, and delayed inflammation resolution could be the underlying mechanism.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Shen, F., Degos, V., Chu, P.-L., Han, Z., Westbroek, E. M., Choi, E.-J., Marchuk, D., Kim, H., Lawton, M. T., Maze, M., Young, W. L., Su, H. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Genetically altered mice, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Basic Sciences Source Type: research

Younger Stroke Patients With Large Pretreatment Diffusion-Weighted Imaging Lesions May Benefit From Endovascular Treatment Clinical Sciences
Conclusions— There was a growing risk for poor outcome and symptomatic intracerebral hemorrhage with increasing pretreatment DWI lesion volumes. Nevertheless, favorable outcome was achieved in every third patient with DWI lesions >70 mL after successful endovascular reperfusion, whereas after poor or failed reperfusion, outcome was favorable in only every 12th patient. Therefore, endovascular treatment might be considered in patients with large DWI lesions, especially in younger patients.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Gilgen, M. D., Klimek, D., Liesirova, K. T., Meisterernst, J., Klinger-Gratz, P. P., Schroth, G., Mordasini, P., Hsieh, K., Slotboom, J., Heldner, M. R., Broeg-Morvay, A., Mono, M.-L., Fischer, U., Mattle, H. P., Arnold, M., Gralla, J., El-Koussy, M., Jun Tags: Acute Cerebral Infarction, Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Risk Profile of Symptomatic Lacunar Stroke Versus Nonlobar Intracerebral Hemorrhage Brief Reports
Conclusions— The risk factor profile of dICH differs from that associated with LS. This might be used for disease risk stratification at individual level.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Morotti, A., Paciaroni, M., Zini, A., Silvestrelli, G., Del Zotto, E., Caso, V., DellAcqua, M. L., Simone, A. M., Lanari, A., Costa, P., Poli, L., De Giuli, V., Gamba, M., Ciccone, A., Ritelli, M., Di Castelnuovo, A., Iacoviello, L., Colombi, M., Agnelli, Tags: Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Identification of Reversible Disruption of the Human Blood-Brain Barrier Following Acute Ischemia Brief Reports
Conclusions— This study demonstrates that diffuse, mild BBB disruption in the acutely ischemic human brain is reversible with reperfusion. This study also confirms prior findings that focal severe BBB disruption confers an increased risk of hemorrhagic transformation in patients treated with intravenous tissue-type plasminogen activator.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Simpkins, A. N., Dias, C., Leigh, R., on behalf of the National Institutes of Health Natural History of Stroke Investigators, Benson, Hsia, Latour, Luby, Lynch, Merino, Nadareishvili, Warach Tags: Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients Clinical Sciences
Conclusions—Our results demonstrated that MT+IVT patients had better functional outcomes, lower mortality, higher rate of successful recanalization, requiring lower number of device passes, and equal odds of symptomatic intracerebral hemorrhage compared with MT−IVT patients. The results support the current guidelines of offering intravenous thrombolysis to eligible patients even if they are being considered for mechanical thrombectomy. Because the data are compiled from studies where the 2 groups differed based on eligibility for intravenous thrombolysis, randomized trials are necessary to accurately evaluate the added...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Eva A. Mistry, Akshitkumar M. Mistry, Mohammad Obadah Nakawah, Rohan V. Chitale, Robert F. James, John J. Volpi, Matthew R. Fusco Tags: Revascularization, Meta Analysis, Quality and Outcomes, Ischemic Stroke Original Contributions Source Type: research

Thrombectomy in Acute Stroke With Tandem Occlusions From Dissection Versus Atherosclerotic Cause Brief Report
Conclusions—We found no differences in the outcomes of patients with anterior circulation tandem atherosclerotic and dissection lesions treated with endovascular thrombectomy. Further studies are warranted.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Benȷamin Gory, Michel Piotin, Diogo C. Haussen, Henrik Steglich–Arnholm, Markus Holtmannspotter, Julien Labreuche, Christian Taschner, Sebastian Eiden, Raul G. Nogueira, Panagiotis Papanagiotou, Maria Boutchakova, Adnan Siddiqui, Bertrand Lap Tags: Revascularization, Stent, Complications, Ischemic Stroke Brief Reports Source Type: research

Low-Dose Tirofiban Improves Functional Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy Clinical Sciences
Conclusions—In patients with AIS undergoing ET, tirofiban is not associated with higher sICH, it seems to lead to lower odds of deaths and better odds of long-term functional independence. Further investigations are needed to determine the efficacy of tirofiban in preventing early reocclusion, the underlying mechanisms, and its optimal treatment protocol.
Source: Stroke - November 27, 2017 Category: Neurology Authors: Wenbo Zhao, Ruiwen Che, Shuyi Shang, Chuanjie Wu, Chuanhui Li, Longfei Wu, Jian Chen, Jiangang Duan, Haiqing Song, Hongqi Zhang, Feng Ling, Yuping Wang, David Liebeskind, Wuwei Feng, Xunming Ji Tags: Revascularization, Quality and Outcomes, Ischemic Stroke Original Contributions Source Type: research

Characteristics of Randomized Trials Focusing on Stroke due to Intracerebral Hemorrhage Clinical Sciences
Background and Purpose—The absence of treatments for intracerebral hemorrhage with significant consistent benefit in randomized controlled trials (RCTs) could be because of lack of treatment efficacy or the design of RCTs.Methods—We searched the Cochrane Stroke Group Trials Register in December 2015 for completed and published RCTs reporting clinical outcome in adults with intracerebral hemorrhage. We collected data on publication year and language, study characteristics, and effect size. We regarded RCTs to be at lower risk of bias if they performed ≥2 of describing randomization, using blinding, or specifying the p...
Source: Stroke - February 26, 2018 Category: Neurology Authors: Arina Tamborska, Michael T.C. Poon, Rustam Al-Shahi Salman Tags: Meta Analysis, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Contributions Source Type: research

Rescue Stenting for Failed Mechanical Thrombectomy in Acute Ischemic Stroke Clinical Sciences
Conclusions—RS was independently associated with good outcomes without increasing symptomatic intracranial hemorrhage or mortality. RS seemed considered in MT-failed internal carotid artery or middle cerebral artery M1 occlusion.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Yoonkyung Chang, Byung Moon Kim, Oh Young Bang, Jang-Hyun Baek, Ji Hoe Heo, Hyo Suk Nam, Young Dae Kim, Joonsang Yoo, Dong Joon Kim, Pyoung Jeon, Seung Kug Baik, Sang Hyun Suh, Kyung-Yul Lee, Hyo Sung Kwak, Hong Gee Roh, Young-Jun Lee, Sang Heum Kim, Chan Tags: Revascularization, Stent, Cerebrovascular Disease/Stroke Original Contributions Source Type: research