• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

LB-007 Selective brain cooling is possible via CSF exchange with double lumen EVD-proof of concept in porcine stroke model
ConclusionWe are first to describe that selective brain cooling is possible via CSF exchange with double lumen EVD to achieve significant temperature difference between body core and brain. The timing and rate of selective cooling needs to be established as cause of arrhythmias before starting human trials.DisclosuresB. Rezai Jahromi: 1; C; IRRAS. 2; C; Neurovascular Innovations. 4; C; Neurovascular Innovations. 6; C; Helsinki Surgical Instruments. N. Järveläinen: None. J. Kauhanen: None. V. Zamotin: None. N. Brandmeir: 1; C; IRRAS. 2; C; IRRAS. M. Niemelä: None. S. Ylä-Herttuala: None.
Source: Journal of NeuroInterventional Surgery - August 3, 2023 Category: Neurosurgery Authors: Rezai Jahromi, B., Järveläinen, N., Kauhanen, J., Zamotin, V., Brandmeir, N., Niemelä, M., Ylä-Herttuala, S. Tags: SNIS 20th annual meeting late-breaking oral abstracts Source Type: research

P-006 Update on the reperfusion with cooling in cerebral acute ischemia II (RECCLAIM II) trial
ConclusionThere is limited evidence demonstrating the clinical benefit or impact of neuroprotection in conjunction with endovascular reperfusion therapy for acute ischemic stroke. Combining intravascular therapeutic hypothermia with endovascular reperfusion therapy may provide an opportunity to enhance clinical outcomes in patients with large vessel occlusion.Disclosures R. Gupta: 1; C; Stryker Neurovascular PI ASSIST Registry, Zoll PI RECCLAIM II (No compensation), Cerenovous Steering Committee MEMBRANE study, Medtronic Steering Committee ELEVATE Study, Penumbra CEC MIND Trial, Vesalio PI CLEAR Study, Rapid Medical PI Tig...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Gupta, R., Zaidi, S., Jumaa, M., Badjatia, N., Yoo, A. Tags: Oral poster abstracts Source Type: research

E-074 Predictors of hemorrhagic conversion following mechanical thrombectomy for acute ischemic stroke (AIS)
ConclusionHistory of prior stroke, radiographic evidence of infarct burden, and radiographic success of thrombectomy may be considered significant predictors for hemorrhagic conversion following AIS in patients who undergo mechanical thrombectomy.Disclosures A. Boyke: None. K. Javed: None. J. Dardick: None. I. Naidu: None. J. Ryvlin: None. D. Kadaba: None. N. Haranhalli: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Boyke, A., Javed, K., Dardick, J., Naidu, I., Ryvlin, J., Kadaba, D., Haranhalli, N. Tags: Electronic poster abstracts Source Type: research

Safety and Efficacy of Hypothermia (34 °C) after Hemicraniectomy for Malignant MCA Infarction.
CONCLUSION: This study suggests that hypothermia after hemicraniectomy is a viable option when the progression of patients with malignant MCA infarction indicate poor prognosis. PMID: 29526071 [PubMed]
Source: Journal of Korean Neurosurgical Society - March 13, 2018 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Management of concomitant metabolic encephalopathy and meningioma with vasogenic edema and impending herniation.
Conclusions: Management of concomitant metabolic encephalopathy and meningioma with vasogenic edema and impending herniation can be challenging. Correction of the encephalopathy is crucial to minimize perioperative morbidity and mortality. Awareness of metabolic causes of acute decompensation is critical for perioperative management, so a high index of clinical suspicion can make an important timely diagnosis for treatment initiation. Severely hypothyroid patients are sensitive to anesthetic agents and are at a high risk for perioperative complications. Prompt treatment prior to surgical intervention can help minimize peri...
Source: Surgical Neurology International - March 3, 2018 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Effect and Feasibility of Therapeutic Hypothermia in Patients with Hemorrhagic Stroke: A  Systematic Review and Meta-Analysis
Therapeutic hypothermia (TH) has shown good results in experimental models of hemorrhagic stroke. The clinical application of TH, however, remains controversial, since reports regarding its therapeutic effect are inconsistent.
Source: World Neurosurgery - January 8, 2018 Category: Neurosurgery Authors: Zhong Yao, Chao You, Min He Tags: Literature Reviews Source Type: research

Effect and feasibility of therapeutic hypothermia in patients with hemorrhagic stroke: a systematic review and meta-analysis
Therapeutic hypothermia (TH) has shown a good performance in the experimental hemorrhagic stroke. But the clinical application of TH remains controversial since reports regarding its therapeutic effect are inconsistent.
Source: World Neurosurgery - January 8, 2018 Category: Neurosurgery Authors: Zhong Yao, Chao You, Min He Tags: Literature Reviews Source Type: research

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke.
Abstract Stroke is a leading cause of disability in the US. Although there has been significant progress in the area of medical and surgical thrombolytic technologies, neuroprotective agents to prevent secondary cerebral injury and to minimize disability remain limited. Only limited success has been reported in preclinical and clinical trials evaluating a variety of compounds. In this review, the authors discuss the most up-to-date information regarding the underlying molecular biology of stroke as well as strategies that aim to mitigate this complex signaling cascade. Results of historical research trials involvi...
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Karsy M, Brock A, Guan J, Taussky P, Kalani MY, Park MS Tags: Neurosurg Focus Source Type: research

Impact of immediate post-reperfusion cooling on outcome in patients with acute stroke and substantial ischemic changes
Conclusions The use of post-reperfusion cooling as a rescue treatment in patients with substantial ischemia at baseline might improve clinical outcome.
Source: Journal of NeuroInterventional Surgery - December 13, 2016 Category: Neurosurgery Authors: Hwang, Y.-H., Jeon, J.-S., Kim, Y.-W., Kang, D.-H., Kim, Y.-S., Liebeskind, D. S. Tags: Ischemic stroke Source Type: research

Therapeutic hypothermia and ischemic stroke: A literature review.
CONCLUSION: Although hypothermia has been used for various purposes over several decades, its efficacy in the treatment of ischemic stroke is debatable. Several trials have proven its safety and feasibility; however, more robust, randomized clinical trials with large volumes of patients are needed to fully establish its utility in the clinical setting. PMID: 27313963 [PubMed]
Source: Surgical Neurology International - June 19, 2016 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Catheter based selective hypothermia reduces stroke volume during focal cerebral ischemia in swine
Conclusions Selective moderate hypothermia was rapidly induced using endovascular techniques in a clinically realistic swine stroke model. A significant reduction in stroke volume on MRI was observed. Endovascular selective hypothermia can provide neuroprotection within time frames relevant to acute ischemic stroke treatment.
Source: Journal of NeuroInterventional Surgery - March 15, 2016 Category: Neurosurgery Authors: Mattingly, T. K., Denning, L. M., Siroen, K. L., Lehrbass, B., Lopez-Ojeda, P., Stitt, L., Pelz, D. M., Das, S., Ang, L.-C., Lee, D. H., Lownie, S. P. Tags: Editor''s choice, Basic science Source Type: research

Multimodality Monitoring, Inflammation, and Neuroregeneration in Subarachnoid Hemorrhage
This study may reveal correlations between markers of inflammation and neurogenesis in blood and cerebrospinal fluid, based on clinical and multimodality monitoring parameters. DISCUSSION: This protocol has the potential to lead to new therapies for acute, diffuse, and severe brain diseases. ABBREVIATIONS: BBB, blood-brain barrier CPP, cerebral perfusion pressure EEG, electroencephalography ICP, intracranial pressure IL, interleukin MCA, middle cerebral artery SAH, subarachnoid hemorrhage SD, spreading depression SGZ, subgranular zone SVZ, subventricular zone TCD, transcranial Doppler
Source: Neurosurgery - November 20, 2014 Category: Neurosurgery Tags: Research-Human-Study Protocols Source Type: research

The epidemiology of spontaneous fever and hypothermia on admission of brain injury patients to intensive care units: a multicenter cohort study.
Conclusions Fever is frequently encountered in the acute phase of brain injury, and a small proportion of patients with brain injuries may also develop spontaneous hypothermia. The effect of fever on mortality rates differed by neurological diagnosis. Both early spontaneous fever and hypothermia conferred a higher risk of in-hospital death after brain injury. PMID: 25105701 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 8, 2014 Category: Neurosurgery Authors: Rincon F, Hunter K, Schorr C, Dellinger RP, Zanotti-Cavazzoni S Tags: J Neurosurg Source Type: research

Emerging experimental therapies for intracerebral hemorrhage: targeting mechanisms of secondary brain injury.
This article reviews the pathophysiology of secondary brain injury relevant to ICH, examines pertinent experimental models, and highlights emerging therapeutic strategies. Treatment paradigms discussed include thrombin inhibitors, deferoxamine, minocycline, statins, granulocyte-colony stimulating factors, and therapeutic hypothermia. Despite promising experimental and preliminary human data, further studies are warranted prior to effective clinical translation. PMID: 23634928 [PubMed - in process]
Source: Neurosurgical Focus - May 1, 2013 Category: Neurosurgery Authors: Belur PK, Chang JJ, He S, Emanuel BA, Mack WJ Tags: Neurosurg Focus Source Type: research