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Specialty: Neurology
Condition: Heatstroke
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Total 26 results found since Jan 2013.
Acquired heat acclimation in rats subjected to physical exercise under environmental heat stress alleviates brain injury caused by exertional heat stroke
Conclusions: This HA model can ameliorate brain injury of EHS by reducing cerebral edema and cell apoptosis, offering experimental evidence for EHS prophylaxis.PMID:37150340 | DOI:10.1016/j.brainres.2023.148393
Source: Brain Research - May 7, 2023 Category: Neurology Authors: Xin Li Fan Xv Li-Zhen Ma Ling Xing Jin-Bao Zhao Wei-Jia Zhi Li-Feng Wang Yang Wang Han-Ding Mao Shu-Yuan Liu Ya-Hua Liu Qing Song Source Type: research
Analysis of Clinical Symptoms of Guillain –Barré Syndrome Induced by Heat Stroke: Three Case Reports and Literature Review
ConclusionsThe number of the cases of GBS induced by HS reported in this study has been the most in the recent 5 years. Clinicians should pay attention to patients with heat stroke with sustained coma and the sudden quadriplegia. Early, exact and timely diagnosis and treatment of GBS need to be performed, to accelerate recovery and improve prognosis.
Source: Frontiers in Neurology - June 17, 2022 Category: Neurology Source Type: research
Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
We here provide an overview of the pathophysiological mechanisms during heat stroke and describe similar mechanisms found in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Both conditions are characterized by disturbed homeostasis in which inflammatory pathways play a central role. Splanchnic vasoconstriction, increased gut permeability, gut-related endotoxemia, systemic inflammatory response, central nervous system dysfunction, blood coagulation disorder, endothelial-cell injury, and mitochondrial dysfunction underlie heat stroke. These mechanisms have also been documented in ME/CFS. Moreover, initial transc...
Source: Frontiers in Neurology - December 13, 2021 Category: Neurology Source Type: research
Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles: A comparative biochemical and physiological study with other stroke therapies
Prog Brain Res. 2021;266:301-348. doi: 10.1016/bs.pbr.2021.06.014. Epub 2021 Oct 6.ABSTRACTMilitary personnel are often exposed to high environmental heat associated with industrial or ambient abundance of nanoparticles (NPs) affecting brain function. We have shown that engineered metal NPs Ag and Cu exacerbate hyperthermia induced brain pathology. Thus, exploration of novel drug therapy is needed for effective neuroprotection in heat stroke intoxicated with NPs. In this investigation neuroprotective effects of cerebrolysin, a balanced composition of several neurotrophic factors and active peptides fragments exhibiting pow...
Source: Brain Research - October 25, 2021 Category: Neurology Authors: Hari Shanker Sharma Dafin F Muresanu Asya Ozkizilcik Seaab Sahib Z Ryan Tian Jos é Vicente Lafuente Rudy J Castellani Ala Nozari Lianyuan Feng Anca D Buzoianu Preeti K Menon Ranjana Patnaik Lars Wiklund Aruna Sharma Source Type: research
Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke
Prog Brain Res. 2021;265:249-315. doi: 10.1016/bs.pbr.2021.06.007. Epub 2021 Aug 12.ABSTRACTMilitary personnel often exposed to high summer heat are vulnerable to heat stroke (HS) resulting in abnormal brain function and mental anomalies. There are reasons to believe that leakage of the blood-brain barrier (BBB) due to hyperthermia and development of brain edema could result in brain pathology. Thus, exploration of suitable therapeutic strategies is needed to induce neuroprotection in HS. Extracts of Gingko Biloba (EGb-761) is traditionally used in a variety of mental disorders in Chinese traditional medicine since ages. I...
Source: Brain Research - September 25, 2021 Category: Neurology Authors: Seaab Sahib Aruna Sharma Dafin F Muresanu Zhiqiang Zhang Cong Li Z Ryan Tian Anca D Buzoianu Jos é Vicente Lafuente Rudy J Castellani Ala Nozari Ranjana Patnaik Preeti K Menon Lars Wiklund Hari Shanker Sharma Source Type: research
NLRP3 ablation enhances tolerance in heat stroke pathology by inhibiting IL-1 β-mediated neuroinflammation
Patients with prior illness are more vulnerable to heat stroke-induced injury, but the underlying mechanism is unknown. Recent studies suggested that NLRP3 inflammasome played an important role in the pathophy...
Source: Journal of Neuroinflammation - June 6, 2021 Category: Neurology Authors: Zi-Teng Zhang, Xiao-Lei Gu, Xin Zhao, Xian He, Hao-Wei Shi, Kun Zhang, Yi-Ming Zhang, Yi-Nan Su, Jiang-Bo Zhu, Zhi-Wei Li and Guo-Bao Li Tags: Research Source Type: research
New genes in neuromuscular diseases
Malignant hyperthermia (MH) and Exertional Heat Stroke (EHS) present hypermetabolic states leading to rhabdomyolysis and muscle rigidity with progressive hyperthermia; MH is triggered by volatile inhaled anesthetics, while EHS is triggered by exercise in hot/humid environment. Given the similarity of clinical features and the fact that a portion of EHS cases were diagnosed as MH susceptible by the in vitro contracture test, MH and EHS are believed to share common etiology. Mutations in RYR1 and CACNA1S have been found to be associated with MH; however the genetic cause remains to be identified in approximately 30% of MH cases.
Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: Y. Endo, L. Groom, N. Kraeva, A. Celic, P. Hopkins, S. Riazi, R. Dirksen, J. Dowling Source Type: research
Sudomotor Dysfunction
Semin Neurol DOI: 10.1055/s-0040-1713847Disorders of sudomotor function are common and diverse in their presentations. Hyperhidrosis or hypohidrosis in generalized or regional neuroanatomical patterns can provide clues to neurologic localization and inform neurologic diagnosis. Conditions that impair sudomotor function include small fiber peripheral neuropathy, sudomotor neuropathy, myelopathy, α-synucleinopathies, autoimmune autonomic ganglionopathy, antibody-mediated hyperexcitability syndromes, and a host of medications. Particularly relevant to neurologic practice is the detection of postganglionic sudomotor deficits ...
Source: Seminars in Neurology - September 8, 2020 Category: Neurology Authors: Cheshire, William P. Tags: Review Article Source Type: research
Unusual manifestation of heat stroke: Isolated trochlear nerve palsy
Heat stroke is a life-threatening disease characterized by hyperthermia and neurological dysfunction. The central nervous system is highly sensitive to hyperthermia, which causes neurological complications due to the involvement of the cerebellum, basal ganglia, anterior horn cells, and peripheral nerves. Several studies reported about clinical symptoms and brain image findings of heat stroke. Isolated cranial nerve dysfunction caused by lacunar infarction is an extremely rare condition in patient with heat stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Sanghoon Han, Baik-kyun Kim, Kyu Sun Yum Tags: Case report Source Type: research
Mesenchymal Stem Cells Provide Neuroprotection by Regulating Heat Stroke-Induced Brain Inflammation
Heat stroke (HS) is the most acute type of heat illness accompanied with serious central nervous system (CNS) dysfunction. Despite the pathological process being clearly studied, effective treatment is deficient. Currently, mesenchymal stem cells (MSCs) have been demonstrated to have neuroprotective effects as there are no old ones. Thus, the purpose of the present study was to explore the neuroprotective effects and mechanisms of MSCs against HS-induced CNS injury. HS in rat models was induced by a high-temperature environment and treated with MSCs via the tail vein. The results demonstrated that MSC injection significant...
Source: Frontiers in Neurology - May 4, 2020 Category: Neurology Source Type: research
Analysis of Clinical Symptoms and Brain MRI of Heat Stroke: 2 Case Reports and a Literature Review
Introduction: Heat stroke is defined as high body temperature causing multiple organ failure, psychological change, seizure, and consciousness disturbance, which lead to its high mortality rate. However, the involvement of brain injury is rare, and heat-stroke has only been reported in a few case reports or case series. The purpose of this case study was to evaluate the clinical symptoms and radiological features of heat stroke. Methods: We reviewed our hospital records and previously published reports to find cases of heat stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2019 Category: Neurology Authors: Tomoyo Shimada, Nobukazu Miyamoto, Yoshiaki Shimada, Masao Watanabe, Hideki Shimura, Yuji Ueno, Kazuo Yamashiro, Nobutaka Hattori, Takao Urabe Source Type: research
Magnetic resonance imaging and magnetic resonance venography features in heat stroke: a case report
Heat stroke (HS) is a critical illness that can cause multiple organ dysfunction, including damage to the central nervous system (CNS), which can be life-threatening in severe cases. Brain lesions in patients ...
Source: BMC Neurology - June 18, 2019 Category: Neurology Authors: Lizhi Cao, Juan Wang, Yaxuan Gao, Yumei Liang, Jinhua Yan, Yunhai Zhang, Mingqin Zhu, Tianfei Luo and Jiafeng Chen Tags: Case report Source Type: research
