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Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine
DiscussionOur results indicate that the poor prognosis of HS patients correlates with severe coagulation disorders, coagulation abnormalities in HS rats are associated with the damage of EGCX, and NAC improves HS-induced coagulopathy, probably through its protection against EGCX injury by preventing ROS generation.
Source: Frontiers in Immunology - June 6, 2023 Category: Allergy & Immunology Source Type: research

Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells
CONCLUSION: Our results indicate that UCP2 protects against HS-induced vascular endothelial damage and that it enhances mitochondrial function. These findings reveal that UCP2 can be a potential contributor to mechanism-based therapeutic strategies for HS.PMID:35129048 | DOI:10.1080/02656736.2022.2032846
Source: International Journal of Hyperthermia - February 7, 2022 Category: Internal Medicine Authors: Wei Huang Liangfeng Mao Weidang Xie Sumin Cai Qiaobing Huang Yanan Liu Zhongqing Chen Source Type: research

Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles: A comparative biochemical and physiological study with other stroke therapies
Prog Brain Res. 2021;266:301-348. doi: 10.1016/bs.pbr.2021.06.014. Epub 2021 Oct 6.ABSTRACTMilitary personnel are often exposed to high environmental heat associated with industrial or ambient abundance of nanoparticles (NPs) affecting brain function. We have shown that engineered metal NPs Ag and Cu exacerbate hyperthermia induced brain pathology. Thus, exploration of novel drug therapy is needed for effective neuroprotection in heat stroke intoxicated with NPs. In this investigation neuroprotective effects of cerebrolysin, a balanced composition of several neurotrophic factors and active peptides fragments exhibiting pow...
Source: Brain Research - October 25, 2021 Category: Neurology Authors: Hari Shanker Sharma Dafin F Muresanu Asya Ozkizilcik Seaab Sahib Z Ryan Tian Jos é Vicente Lafuente Rudy J Castellani Ala Nozari Lianyuan Feng Anca D Buzoianu Preeti K Menon Ranjana Patnaik Lars Wiklund Aruna Sharma Source Type: research

Ethyl pyruvate ameliorates heat stroke-induced multiple organ dysfunction and inflammatory responses by induction of stress proteins and activation of autophagy in rats
Conclusion: In conclusion, EP ameliorated HS-induced inflammatory responses and MOD, and the underlying mechanism is associated with the induction of the stress proteins HO-1 and HSP70 as well as restorage of autophagy.PMID:34078225 | DOI:10.1080/02656736.2021.1931479
Source: International Journal of Hyperthermia - June 3, 2021 Category: Internal Medicine Authors: Je-Ming Hu Chih-Hsueng Hsu Yu-Chun Lin Ching-Wen Kung Shu-Ying Chen Wen-Ting Lin Pao-Yun Cheng Hsin-Hsueh Shen Yen-Mei Lee Source Type: research

Myricetin against myocardial injury in rat heat stroke model.
CONCLUSIONS: Our results indicate that myricetin diminishes myocardial injury as well as lethality in heat stroke by up-regulating HSP-72 and show promise as a novel prevention therapeutic for heat stroke. PMID: 32371315 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2020 Category: Drugs & Pharmacology Authors: Lin X, Lin CH, Liu R, Li C, Jiao S, Yi X, Walker MJ, Xu XM, Zhao T, Huang PC, Sun G Tags: Biomed Pharmacother Source Type: research

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds
Publication date: July 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 3Author(s): Jerome G. Ganzon, Lih-Geeng Chen, Ching-Chiung WangAbstractMulberry (Morus alba L.) leaves are widely used as herbal tea to prevent heat stroke. Potential chemical markers of the antioxidant properties and its correlation with harvesting times and leaf location were explored in this study. A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay guided isolation of mulberry leaves extract provided five phenolic compounds: 5-O-caffeoylquinic acid (1), 4-O-caffeoylquinic acid (2), gastrodin (3), isoquercetin (4) and ruti...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research

Melatonin provides protection against heat stroke ‐induced myocardial injury in male rats
ConclusionsMelatonin may protect against HS‐induced myocardial injury in male rats by mitigating oxidative stress and inflammation.
Source: Journal of Pharmacy and Pharmacology - February 27, 2018 Category: Drugs & Pharmacology Authors: Xiaojing Lin, Tingbao Zhao, Cheng ‐Hsien Lin, Dan Zuo, Zhujun Ye, Shide Lin, Shaonan Wen, Lin Liu, Mao‐Tsun Lin, Ching‐Ping Chang, Chien‐Ming Chao Tags: Research Paper Source Type: research

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds
Publication date: Available online 19 December 2017 Source:Journal of Food and Drug Analysis Author(s): Jerome G. Ganzon, Lih-Geeng Chen, Ching-Chiung Wang Mulberry (Morus alba L.) leaves are widely used as herbal tea to prevent heat stroke. Potential chemical markers of the antioxidant properties and its correlation with harvesting times and leaf location were explored in this study. A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay guided isolation of mulberry leaves extract provided five phenolic compounds: 5-O-caffeoylquinic acid (1), 4-O-caffeoylquinic acid (2), gastrodin (3), isoquercetin (4) and rutin...
Source: Journal of Food and Drug Analysis - December 19, 2017 Category: Food Science Source Type: research