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Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine
DiscussionOur results indicate that the poor prognosis of HS patients correlates with severe coagulation disorders, coagulation abnormalities in HS rats are associated with the damage of EGCX, and NAC improves HS-induced coagulopathy, probably through its protection against EGCX injury by preventing ROS generation.
Source: Frontiers in Immunology - June 6, 2023 Category: Allergy & Immunology Source Type: research

Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury.
Conclusion: This study provides strong evidence that HS causes damage to both the small intestine and intestinal epithelial cells, scavenging ROS production can significantly alleviate such RIPK1/RIPK3-dependent necroptosis, mediating HS-induced intestinal damage both in vitro and in vivo. These findings provide a clear target for future mechanism-based therapeutic strategies for patients diagnosed with heat stroke. PMID: 32423248 [PubMed - in process]
Source: International Journal of Hyperthermia - May 21, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A knack for “NAC”: treatment for heat stroke induced acute liver injury: A case report
We present a case of heat stroke resulting in acute liver injury (ALI) successfully treated with intravenous N-acetylcysteine (NAC).
Source: The American Journal of Emergency Medicine - November 27, 2019 Category: Emergency Medicine Authors: Brian Monzon, Kathleen Hegarty, Megan A. Rech Source Type: research

A knack for “NAC”: Treatment for heat stroke induced acute liver injury
We present a case of heat stroke resulting in acute liver injury (ALI) successfully treated with intravenous N-acetylcysteine (NAC).
Source: The American Journal of Emergency Medicine - November 27, 2019 Category: Emergency Medicine Authors: Brian Monzon, Kathleen Hegarty, Megan A. Rech Tags: Case Report Source Type: research

N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis.
Authors: Will JS, Snyder CJ, Westerfield KL Abstract Exertional Heat Illness with associated ischemic hepatitis (IH) is a common occurrence among military trainees; however, few specific therapies exist if unresponsive to appropriate supportive measures. A 27-year-old basic combat trainee presented with altered mental status, renal insufficiency, rhabdomyolysis, and a core temp of 107.9 °F after collapsing during a run, leading to the diagnosis of heat stroke. While the patient's azotemia and creatinine kinase levels rapidly improved with aggressive intravenous hydration, transaminases continued to increase to nea...
Source: Military Medicine - March 1, 2019 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Heat stress induces intestinal injury through lysosome- and mitochondria-dependent pathway in vivo and in vitro.
Authors: Yi G, Li L, Luo M, He X, Zou Z, Gu Z, Su L Abstract Damage to the small intestine secondary to heat stroke is a major factor in heat stroke-related morbidity and mortality. However, the underlying mechanisms by which heat stroke causes small intestinal lesions and dysfunction remain unclear. To explore the pathogenesis of small intestinal tissue and epithelial cell injury, the SW480 cell heat stress model and the mice heat stroke model were established to mimic heat stroke. Morphologic changes in intestinal tissue and increased TUNEL-positive index were induced by heat stress in vivo. Heat stress activated...
Source: Oncotarget - April 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research