Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury.

Conclusion: This study provides strong evidence that HS causes damage to both the small intestine and intestinal epithelial cells, scavenging ROS production can significantly alleviate such RIPK1/RIPK3-dependent necroptosis, mediating HS-induced intestinal damage both in vitro and in vivo. These findings provide a clear target for future mechanism-based therapeutic strategies for patients diagnosed with heat stroke. PMID: 32423248 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32423248?dopt=Abstract

Source: International Journal of Hyperthermia - May 21, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research