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Specialty: Molecular Biology
Condition: Heart Failure

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Total 29 results found since Jan 2013.

Negative correlation between organ heteroplasmy, particularly hepatic heteroplasmy, and age at death revealed by post-mortem studies of m.3243A   & gt;  G cases
Mol Genet Metab. 2023 Aug 28;140(3):107691. doi: 10.1016/j.ymgme.2023.107691. Online ahead of print.ABSTRACTMitochondrial DNA m.3243A > G mutation causes mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and its associated multi-organ disorders, including diabetes. To clarify associations between m.3243A > G organ heteroplasmy and clinical phenotypes, including the age at death, we combined genetic and pathological examinations from seven unreported and 36 literature cases of autopsied subjects. Clinical characteristics of subjects were as follows: male, 13; female, 28; unknown, 2; the a...
Source: Molecular Medicine - September 3, 2023 Category: Molecular Biology Authors: Kunimasa Yagi Satoko Okazaki Azusa Ohbatake Masako Nakaya Jianhui Liu Eiko Arite Yukiko Miyamoto Naoko Ito Kaoru Nakano Naoto Yamaaki Hisae Honoki Shiho Fujisaka Daisuke Chujo Shin-Ichiro Tsunoda Kunio Yanagimoto Tsuyoshi Nozue Masayo Yamada Kotaro Ooe Ts Source Type: research

The prognostic value of CZT SPECT myocardial blood flow (MBF) quantification in patients with ischemia and no obstructive coronary artery disease (INOCA): a pilot study
CONCLUSION: The preliminary results demonstrated that quantitative analysis on CZT SPECT provides prognostic value for INOCA patients, which may allow the stratification for early prevention and intervention.PMID:36786817 | DOI:10.1007/s00259-023-06125-3
Source: Molecular Medicine - February 14, 2023 Category: Molecular Biology Authors: Han Zhang Federico Caobelli Wenliang Che Yan Huang Yu Zhang Xin Fan Xueping Hu Chong Xu Mengyu Fei Jiajia Zhang Zhongwei Lv Kuangyu Shi Fei Yu Source Type: research

The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition
Int J Mol Sci. 2022 Oct 8;23(19):11965. doi: 10.3390/ijms231911965.ABSTRACTA crucial etiological component in fetal programming is early nutrition. Indeed, early undernutrition may cause a chronic increase in blood pressure and cardiovascular diseases, including stroke and heart failure. In this regard, current evidence has sustained several pathological mechanisms involving changes in central and peripheral targets. In the present review, we summarize the neuroendocrine and neuroplastic modifications that underlie maladaptive mechanisms related to chronic hypertension programming after early undernutrition. First, we anal...
Source: Molecular Medicine - October 14, 2022 Category: Molecular Biology Authors: Bernardita Cayupe Blanca Troncoso Carlos Morgan Patricio S áez-Briones Ram ón Sotomayor-Zárate Luis Constandil Alejandro Hern ández Eugenia Morselli Rafael Barra Source Type: research

The unexpected benefits of sodium glucose co-transporter 2 (SGLT2) Inhibitors
N Z Med J. 2022 Aug 19;135(1560):99-104.ABSTRACTThe sodium glucose co-transporter 2 (SGLT2) inhibitor empagliflozin is currently funded in New Zealand for management of patients with type 2 diabetes who have an HbA1c >53mmol/mol and a high cardiovascular (CV) risk. Large clinical trials now provide strong evidence that SGLT2 inhibitors decrease the risk of cardiovascular death, heart failure, progressive kidney dysfunction, myocardial infarction, stroke and gout. Patients with or without diabetes who have a history of heart failure, including those with a preserved left ventricular ejection fraction and patients with ch...
Source: Molecular Medicine - August 24, 2022 Category: Molecular Biology Authors: Chok G Chan Ralph Stewart Source Type: research

Matrix metalloproteinase 3 and 9 as genetic biomarkers for the occurrence of cardiovascular complications in coronary artery disease: a prospective cohort study
CONCLUSION: Our study suggests the disruption of the MMP-3 level may be due to the existence of the polymorphism - 1612 residing in its promoter region. MMP-3 can be considered as a marker of diagnosis and prediction in cardiovascular events.PMID:35960412 | DOI:10.1007/s11033-022-07742-1
Source: Molecular Biology Reports - August 12, 2022 Category: Molecular Biology Authors: Imen Guizani Wiem Zidi Yosra Zayani Fourti Nesrine Hayet Douik Haifa Sanhaji Mohamed Sami Mourali Moncef Feki Monia Allal-Elasmi Source Type: research

Genetics of atrial fibrillation-an update of recent findings
Mol Biol Rep. 2022 May 19. doi: 10.1007/s11033-022-07420-2. Online ahead of print.ABSTRACTAtrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong genetic predisposition. This review highlights the recent findings on the genetics of AF from genome-wide association studies (GWAS) and high-throughput sequencing studies. The consensus from GWAS implies that AF is both polygenic and pleiotropic in nature. With the advent of whole-genome sequencing and whole-exome sequencing, rare variants associated with AF pathogenesis have been identified....
Source: Molecular Biology Reports - May 19, 2022 Category: Molecular Biology Authors: Aarthi Manoharan Ravikumar Sambandam Vishnu Bhat Ballambattu Source Type: research

Cerebral derailment after myocardial infarct: mechanisms and effects of the signaling from the ischemic heart to brain
J Mol Med (Berl). 2021 Oct 21. doi: 10.1007/s00109-021-02154-3. Online ahead of print.ABSTRACTMyocardial infarction (MI) is the leading cause of death among ischemic heart diseases and is associated with several long-term cardiovascular complications, such as angina, re-infarction, arrhythmias, and heart failure. However, MI is frequently accompanied by non-cardiovascular multiple comorbidities, including brain disorders such as stroke, anxiety, depression, and cognitive impairment. Accumulating experimental and clinical evidence suggests a causal relationship between MI and stroke, but the precise underlying mechanisms ha...
Source: Molecular Medicine - October 21, 2021 Category: Molecular Biology Authors: Paolo Gelosa Laura Castiglioni Joanna Rzemieniec Majeda Muluhie Marina Camera Luigi Sironi Source Type: research

From air pollution to cardiovascular diseases: the  emerging role of epigenetics.
From air pollution to cardiovascular diseases: the emerging role of epigenetics. Mol Biol Rep. 2020 Jun 06;: Authors: Micheu MM, Birsan MV, Szép R, Keresztesi Á, Nita IA Abstract The association between air pollution and a wide-ranging spectrum of acute and chronic disorders-including cardiovascular diseases-is widely acknowledged. Exposure to airborne pollutants triggers harmful mechanisms such as oxidative stress and systemic inflammation, which lead to increased incidence of myocardial infarction, arterial hypertension, stroke, and heart failure. Sustained efforts have been made in recent year...
Source: Molecular Biology Reports - June 5, 2020 Category: Molecular Biology Authors: Micheu MM, Birsan MV, Szép R, Keresztesi Á, Nita IA Tags: Mol Biol Rep Source Type: research

Comparison of longitudinal change in sST2 vs BNP to predict major adverse cardiovascular events in asymptomatic patients in the community.
In conclusion, longitudinal change in sST2 but not BNP was associated with incident MACE in asymptomatic, initially event-free patients in the community. Further work is required to evaluate the clinical utility of change in sST2 in risk prediction and event monitoring in this setting. PMID: 32347644 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - April 28, 2020 Category: Molecular Biology Authors: Watson CJ, Tea I, O'Connell E, Glezeva N, Zhou S, James S, Gallagher J, Snider J, Januzzi JL, Ledwidge MT, McDonald KM Tags: J Cell Mol Med Source Type: research

Arrhythmia susceptibility in a rat model of acute atrial dilation
In conclusion, CV decrease is not sufficient to promote arrhythmias; enlargement of atrial surface is essential to create a substrate for acute reentry-based arrhythmias.
Source: Progress in Biophysics and Molecular Biology - February 14, 2020 Category: Molecular Biology Source Type: research