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Total 11296 results found since Jan 2013.

Role of Iberin as an anti-apoptotic agent on renal ischemia-reperfusion injury in rats
This study aimed to investigate the therapeutic potential of Iberin, known for its anti-inflammatory, antioxidant, and antiapoptotic properties, in a rat model of renal IRI. Twenty-four adult male rats were randomly divided into four groups: Group I (Sham group) underwent laparotomy without IRI induction; Group II (Control group) underwent laparotomy followed by renal artery clamping for 30 minutes to induce ischemia, followed by 2 hours of reperfusion; Group III (Iberin treatment group) received a pre-injection of Iberin (15 mg/kg) and underwent 30 minutes of ischemia followed by 2 hours of reperfusion; and Group IV (Vehi...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Yahiya Ibrahim Yahiya Najah Rayish Hadi Ahmed Abu Raghif Heider Qassam Noor Ghaffar Said Al Habooby Source Type: research

Intra-Arterial Thrombectomy for Acute Ischemic Stroke Related to the Procoagulant Effect of Warfarin in A Patient with Atrial Fibrillation and Bioprosthetic Valve Replacement
CONCLUSION: This report describes the roles of endovascular therapy and NOAC in patients with similar highly complex conditions and has clinical relevance for therapeutic plans in the clinical setting.PMID:37674421
Source: Acta Neurologica Taiwanica - September 7, 2023 Category: Neurology Authors: Hsu-Tung Huang Yi-Ting Huang David Yen-Ting Chen Lung Chan Chien-Tai Hong Chen-Chih Chung Source Type: research

Trends in cardiovascular complications of pregnancy: A nationwide inpatient sample analysis
CONCLUSION: There are concerning increases in certain cardiac complications during pregnancy. This is likely due to increasing age at the time of pregnancy and associated comorbidities.PMID:37678669 | DOI:10.1016/j.amjms.2023.09.001
Source: The American Journal of the Medical Sciences - September 7, 2023 Category: General Medicine Authors: Eric D Warner Saaniya Farhan Matthew Bierowski Farhan Sahawneh Estefania Oliveros Preethi Pirlamarla Stefanie Marek-Iannucci Bhavadharini Ramu Waqas Ullah Yevgeniy Brailovsky Indranee N Rajapreyar Source Type: research

Starting Pediatric VAD Program: Transforming Challenges into Opportunities; A Case Series of a Single Center
CONCLUSIONS: To establish a VAD program, numerous specialties must be included with adequate training and learning for all team members.PMID:37679088 | DOI:10.59958/hsf.5545
Source: The Heart Surgery Forum - September 7, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Matija Bako š Milivoj Novak Dalibor Šarić Dorotea Bartoni ček Dra žen Belina Željko Đurić Darko Ani ć Željko Čolak Sanja Konosi ć Marina Mihalec Filip Rubi ć Toni Mati ć Goran Me đimurec Mislav Planinc Source Type: research

Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
In this study, we investigated the anti-ferroptosis effects of suberosin (SBR; a prenylated coumarin) in diabetic Sprague Dawley rats. Further, we assessed the effects of co-administration of SBR (30 and 90 mg/kg/day) with thiazolidinedione (TZ at 15 mg/kg) to mitigate TZ-induced cardiomyopathy in diabetic rats. Our results showed that cardiac output, stroke volume, left ventricle systolic and diastolic pressures were aggravated in diabetic rats treated with TZ alone after 4 weeks. TZ treatments induced ferroptosis as well as marked histoarchitecture disarrangements in rat cardiomyocytes. The study found that optimizing vo...
Source: Cardiovascular Toxicology - September 7, 2023 Category: Cardiology Authors: Shabnoor Iqbal Farhat Jabeen Ivan Kahwa Timothy Omara Source Type: research

Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke ? Discordance between randomised controlled trials and observational studies
Diabetes Metab. 2023 Sep 5:101474. doi: 10.1016/j.diabet.2023.101474. Online ahead of print.ABSTRACTStroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular complication has been less carefully investigated than the risk of cardiovascular mortality, heart failure and renal disease. Some data suggested that glucagon peptide-1 receptor agonists (GLP-1RAs) exert a better protection against stroke than sodium-glucose cotransporter 2 inhibitors (SGLT2is). However, this conclusion was derived from indirect comparisons in absence of any head-to-head randomised controlled trial (RCT). The present...
Source: Diabetes and Metabolism - September 7, 2023 Category: Endocrinology Authors: Andr é J Scheen Source Type: research

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