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Clinical trial participant ’s autopsy and brain exam stoke Alzheimer’s drug fears
A full autopsy and detailed examination of the brain of a 79-year-old Florida woman who died after receiving lecanemab, an experimental Alzheimer’s therapy, in a pivotal clinical trial has deepened some researchers’ concerns that it poses serious risks for patients who share the woman’s hard-to-diagnose, preexisting condition. The patient’s history and autopsy “strongly suggests that lecanemab infusions were a catalyst leading to the events resulting in her death,” says Vanderbilt University pathologist Hannah Harmsen, co-author of a recently completed case report, which Science has obtained. The aut...
Source: Science of Aging Knowledge Environment - April 13, 2023 Category: Geriatrics Source Type: research

Leading migraine researcher supported by the NIH wins The Brain Prize 2021
(NIH/National Institute of Neurological Disorders and Stroke) The Brain Prize has been awarded to Michael A. Moskowitz, M.D., a professor of neurology at Harvard Medical School at the Massachusetts General Hospital, Charlestown, who also is supported by an NIH grant.
Source: EurekAlert! - Medicine and Health - March 5, 2021 Category: International Medicine & Public Health Source Type: news

Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Migraine linked to increased risk of stroke after surgery.
Authors: Abstract Patients who experience migraine have a greater risk of stroke and readmission to hospital after undergoing surgery, say researchers from Harvard Medical School in the United States. PMID: 28145176 [PubMed - in process]
Source: Nursing Standard - January 31, 2017 Category: Nursing Tags: Nurs Stand Source Type: research

Migraine sufferers are at high risk of having a stroke during surgery, study finds
Despite being viewed as a benign condition, having a migraine also increases the chances of being readmitted to hospital, a new study by Harvard Medical School discovered.
Source: the Mail online | Health - January 11, 2017 Category: Consumer Health News Source Type: news

Women with a history of imigraines are at double the risk of having a stroke
A two-decade study of 115,000 women, by Harvard University researchers, found that those who complained of migraines were 50 per cent more likely to develop major heart problems.
Source: the Mail online | Health - November 16, 2016 Category: Consumer Health News Source Type: news

E-043 Reversible Cerebral Vasoconstriction Syndrome: Non-invasive Imaging Findings and Angiographic Evaluation
We present indirect findings on non-invasive imaging, such as transient cerebral edema, convexal subarachnoid hemorrhage, intraparenchymal hemorrhage and cerebral. Direct signs of single or multivessel arterial vasoconstriction are seen on CTA, MRA and confirmed on DSA. Reversibility of the vasoconstriction is demonstrated after intra-arterial administration of calcium channel blocker. Conditions such as diffuse atherosclerotic arterial narrowing, vasculitis, posterior reversible encephalopathy, cerebral edema secondary to venous congestion and vasospasm secondary to aneurysmal subarachnoid hemorrhage were among the pathol...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: de Macedo Rodrigues, K., Hito, R., Takhtani, D., Lozano, J., Wakhloo, A., Puri, A. Tags: Electronic poster abstracts Source Type: research

Women With Migraines Are More Prone To This Scary Health Condition
This study provides really good quality evidence that migraine in women is a risk factor for cardiovascular disease," said Dr. Rebecca Burch, an instructor in the department of neurology at Harvard Medical School in Boston, who wrote an editorial accompanying the study, but was not involved in the research. Migraines have a fairly small effect on cardiovascular risk compared with other known risk factors that have a much larger influence on heart disease, such as smoking, high blood pressure or high cholesterol, Burch said. However, because migraines are relatively common, affecting an estimated 1 in 4 American women, this...
Source: Healthy Living - The Huffington Post - June 2, 2016 Category: Consumer Health News Source Type: news

Migraines linked to increased heart disease risk in women
Conclusion This study shows a strong link between migraine and cardiovascular disease, extending the link already found between migraine and stroke. However, many questions remain. We don't know if the results are relevant to men who have migraines, as all the people in the study were women. We also don't know if the results apply to non-white populations, as most of the women in the study were white. Previous studies on stroke have shown that the group at highest risk is who get an "aura" before a migraine – sensation(s) that tells them the migraine is on its way. But this study did not ask people about aura...
Source: NHS News Feed - June 1, 2016 Category: Consumer Health News Tags: Heart/lungs Neurology Source Type: news

High blood pressure: Why me?
“I go to the gym, and I never add salt. So why do I have high blood pressure?” Despite its astonishing prevalence of one in three Americans, many people struggle with the diagnosis of high blood pressure, or hypertension. It’s worth exploring why, because being an active participant in your care is crucial for optimal blood pressure control. Certain features make any diagnosis easier to accept: First, people are more likely to accept a diagnosis if they have symptoms. A person with cough and fever will believe a diagnosis of pneumonia. But someone who feels fine would not. Next, people more readily accept a diagnosi...
Source: New Harvard Health Information - May 2, 2016 Category: Consumer Health News Authors: Naomi D. L. Fisher, MD Tags: Behavioral Health Health care Heart Health Hypertension and Stroke Prevention Screening high blood pressure Source Type: news

Don’t shrug off shingles
If you had chickenpox as a kid, there is a good chance you may develop shingles later in life. “In fact, one in three is predicted to get shingles during their lifetime,” says Dr. Anne Louise Oaklander, director of the Nerve Unit at Harvard-affiliated Massachusetts General Hospital. The same varicella-zoster virus that causes chickenpox also causes shingles. After the telltale spots of chickenpox vanish, the virus lies dormant in your nerve cells near the spinal cord and brain. When your immunity weakens from normal aging or from illnesses or medications, the virus can re-emerge. It then travels along a nerve to trigge...
Source: New Harvard Health Information - February 18, 2016 Category: Consumer Health News Authors: Matthew Solan Tags: Healthy Aging Infectious diseases Vaccines Source Type: news

Are We Working Ourselves to Death?
If you are an executive, manager, emergency medicine physician (EMP), Silicon Valley employee or struggling law associate, you and many like you are probably working more than 60 hours a week. According to a survey published in the Harvard Business Review a few years ago, you may be working an average of 72 hours a week. Contrast this with the government's desire to limit excessive working hours about 80 years ago when, on June 25, 1938, Franklin D. Roosevelt signed into law the Fair Labor Standards Act (FLS). This law banned oppressive child labor, set the minimum hourly wage at 25 cents, and the maximum workweek at 44 h...
Source: Healthy Living - The Huffington Post - September 1, 2015 Category: Consumer Health News Source Type: news

FDA strengthens warning that NSAIDs increase heart attack and stroke risk
Back in 2005, the FDA warned that taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen increased the risk of having a heart attack or stroke. Last week it took the unusual step of further strengthening this warning. This was done on the advice of an expert panel that reviewed new information about NSAIDs and their risks. Because NSAIDs are widely used, it’s important to be aware of downsides of taking an NSAID and to take steps to limit the risk. Many people take NSAIDs to relieve mild to moderate pain. These medications may be particularly effective in conditions in which pain results pri...
Source: New Harvard Health Information - July 13, 2015 Category: Consumer Health News Authors: Gregory Curfman, MD Tags: Heart Health heart attack heart disease NSAIDS Stroke Source Type: news

Twin surgeries bring this family a stroke of luck
Ryan Earle is outgoing and upbeat, goofing around in his neurosurgeon’s office. He’s had two strokes, but he’s recovering steadily, a testament to the resilience of children’s brains. His twin brother Tyler, with him at the visit, has avoided a likely stroke altogether. Both Ryan and Tyler, 8, have a rare brain disorder called moyamoya disease, in which the internal carotid arteries become narrowed, slowing the flow of blood to their brains. Without surgery, moyamoya poses a five-year stroke risk of 60 to 90 percent. The boys’ moyamoya symptoms were subtle: “They would have a mild headache, then they’d throw ...
Source: Thrive, Children's Hospital Boston - December 29, 2014 Category: Pediatrics Authors: Lisa Fratt Source Type: news

Don't brush off early warning signs of a stroke
It's important to recognize the signs of a stroke and get to a hospital fast. Time is brain: the longer the gap between the start of stroke symptoms and treatment, the more brain cells die, reports the December 2013 issue of the Harvard Men's Health Watch. Experts have developed the FAST (Face, Arms, Speech, Time) mnemonic device to highlight some of the more obvious signs of a brain attack. A more detailed list includes: Face drooping. One side of the face goes slack. A smile appears uneven. One arm is weak. When raising both arms, one arm drifts downward. Numbness. Loss of feeling on one side of the body, or one part of...
Source: New Harvard Health Information - November 30, 2013 Category: Consumer Health News Source Type: news