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Predictive values of coronary artery calcium and arterial stiffness for long-term cardiovascular events in patients with stable coronary artery disease
CONCLUSIONS: A CAC score ≥100 or a CAVI ≥ 9.0 predicts the long-term occurrence of MACEs in both asymptomatic and symptomatic patients with stable CAD. These two noninvasive tests can be used as screening tools to guide treatment for the prevention of future CV events.PMID:36448219 | DOI:10.1002/clc.23955
Source: Atherosclerosis - November 30, 2022 Category: Cardiology Authors: Thosaphol Limpijankit Sutipong Jongjirasiri Krissada Meemook Nattawut Unwanatham Ammarin Thakkinstian Jiraporn Laothamatas Source Type: research

Incidence of atrial fibrillation in elderly patients with type 2 diabetes mellitus
CONCLUSIONS: Annually, 1 in 200 elderly Japanese patients with T2D are estimated to develop AF. Because elderly patients with T2D with AF are at an elevated risk for CVD, careful follow-up of this patient subgroup is necessary.TRIAL REGISTRATION NUMBER: NCT00110448.PMID:35361621 | DOI:10.1136/bmjdrc-2021-002745
Source: Atherosclerosis - April 1, 2022 Category: Cardiology Authors: Chisa Matsumoto Hisao Ogawa Yoshihiko Saito Sadanori Okada Hirofumi Soejima Mio Sakuma Izuru Masuda Masafumi Nakayama Naofumi Doi Hideaki Jinnouchi Masako Waki Takeshi Morimoto Source Type: research

Posterior Circulation Ischaemic Stroke
Am J Med Sci. 2022 Jan 29:S0002-9629(22)00030-1. doi: 10.1016/j.amjms.2021.10.027. Online ahead of print.ABSTRACTPosterior circulation ischaemic stroke (PCIS) is a disease of high burden. They account for 20-25% of all ischaemic strokes. However, it is relatively under-researched and requires more clinical attention, since it carries worse functional outcomes. Vertigo, visual disturbances and sensory/motor disturbances are found in PCIS. Large artery atherosclerosis and embolism are main causes of PCIS, while there is growing evidence that vertebrobasilar dolichoectasia is a key association. Hypertension is the commonest r...
Source: The American Journal of the Medical Sciences - February 1, 2022 Category: General Medicine Authors: Mr Alexander Ng Source Type: research

Determinants of Incident Atherosclerotic Cardiovascular Disease Events Among Those With Absent Coronary Artery Calcium: Multi-Ethnic Study of Atherosclerosis
Conclusions: Current cigarette smoking, diabetes mellitus, and hypertension are independently associated with incident ASCVD over 16-year follow-up among those with CAC=0. Family history of premature ASCVD may be associated with ASCVD risk among women only.PMID:34879218 | DOI:10.1161/CIRCULATIONAHA.121.056705
Source: Atherosclerosis - December 8, 2021 Category: Cardiology Authors: Mahmoud Al Rifai Michael J Blaha Vijay Nambi Steven J C Shea Erin D Michos Roger S Blumenthal Christie M Ballantyne Moyses Szklo Philip Greenland Michael D Miedema Khurram Nasir Jerome I Rotter Xiuqing Guo Jie Yao Wendy S Post Salim S Virani Source Type: research

Patients with stable coronary artery disease and type 2 diabetes but without prior myocardial infarction or stroke and THEMIS-like patients: real-world prevalence and risk of major outcomes from the SNDS French nationwide claims database
The THEMIS randomized trial compared ticagrelor plus aspirin versus placebo plus aspirin for patients with stable coronary artery disease and type 2 diabetes mellitus (CAD-T2DM), and without prior myocardial i...
Source: Cardiovascular Diabetology - November 25, 2021 Category: Cardiology Authors: Patrick Blin, Patrice Darmon, Patrick Henry, Estelle Guiard, Marie-Agn ès Bernard, Caroline Dureau-Pournin, Hélène Maizi, Florence Thomas-Delecourt, Régis Lassalle, Cécile Droz-Perroteau and Nicholas Moore Tags: Original investigation Source Type: research

Impact of Diabetes on Platelet Function in Acute Ischemic Stroke Patients Taking Dual Antiplatelet Therapy
Conclusions: In acute ischemic stroke patients taking DAPT, DM is associated with increased platelet reactivity and higher prevalence of clopidogrel HRPR.
Source: Frontiers in Neurology - November 4, 2021 Category: Neurology Source Type: research

Impaired Clinical Efficacy of Aspirin in Hypoalbuminemic Patients With Diabetes Mellitus
Conclusion: In T2DM patients, the efficacy of aspirin varies according to albumin levels. Hypoalbuminemia associated with impaired TxB2 inhibition and an increased risk of long-term CVEs.
Source: Frontiers in Pharmacology - June 22, 2021 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Ticagrelor in Diabetes Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Controlled Trials
Abstract: Dual antiplatelet treatment, consisting of aspirin and P2Y12 inhibitors, is essential for diabetes mellitus (DM) patients who have undergone percutaneous coronary intervention (PCI). This meta-analysis investigated whether ticagrelor, a novel P2Y12 inhibitor, was superior to clopidogrel and prasugrel in efficacy and safety for DM patients undergoing PCI. PubMed, the Cochrane Library and Google Scholar were searched for randomized controlled trials in which ticagrelor was administered. Eligible studies were independently scrutinized to extract data and assess the trials' quality. Statistical analysis was perfo...
Source: Journal of Cardiovascular Pharmacology - May 1, 2021 Category: Cardiology Tags: Review Article Source Type: research

Dual therapy with an oral non-vitamin K antagonist and a P2Y12 inhibitor vs triple therapy with aspirin, a P2Y12 inhibitor and a vitamin K antagonist for the treatment of diabetes mellitus patients with co-existing atrial fibrillation following percutaneous coronary intervention: A meta-analysis
Conclusions: DT with a NOAC and a P2Y12 inhibitor was associated with significantly less bleeding events without increasing the adverse cardiovascular outcomes when compared to TT with aspirin, a P2Y12 inhibitor and a Vitamin K antagonist for the treatment of DM patients with co-existing AF following PCI. Hence, DT is comparable in efficacy, but safer compared to TT. This interesting hypothesis will have to be confirmed in future studies.
Source: Medicine - April 16, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

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