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Condition: Dementia
Procedure: Anesthesia

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Total 21 results found since Jan 2013.

Sex differences in clinical outcomes amongst 1105 patients admitted with hip fractures
AbstractAmongst hip fracture admissions, mortality is higher in men than in women. However, sex differences in other care-quality measures have not been well-documented. We aimed to examine sex differences in mortality as well as a wide range of underlying health indicators and clinical outcomes in adults  ≥ 60 year of age admitted with hip fractures from their own homes to a single NHS hospital between April-2009 and June-2019. Sex differences in delirium, length of stay (LOS) and mortality in hospital, readmission, and discharge destination, were examined by logistic regression. There were 7 87 women and 318 men o...
Source: Internal and Emergency Medicine - April 26, 2023 Category: Emergency Medicine Source Type: research

Widespread Pain Tied to Dementia, Alzheimer Disease, Stroke
TUESDAY, Aug. 17, 2021 -- Widespread pain, a common subtype of chronic pain, is associated with the subsequent risk for incident dementia, Alzheimer disease dementia, and stroke, according to a study published online Aug. 16 in Regional Anesthesia...
Source: Drugs.com - Pharma News - August 17, 2021 Category: Pharmaceuticals Source Type: news

Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis
Impaired cerebrovascular function is an early biomarker for cerebral amyloid angiopathy (CAA), a neurovascular disease characterized by amyloid- β accumulation in the cerebral vasculature, leading to stroke and dementia. The transgenic Swedish Dutch Iowa (Tg-SwDI) mouse model develops cerebral microvascular amyloid-β deposits, but whether this leads to similar functional impairments is incompletely understood. We assessed cerebrovascular f unction longitudinally in Tg-SwDI mice with arterial spin labeling (ASL)-magnetic resonance imaging (MRI) and laser Doppler flowmetry (LDF) over the course of amyloid-β deposition. Un...
Source: eLife - February 12, 2021 Category: Biomedical Science Tags: Neuroscience Source Type: research

Anesthesia and Alzheimer & #39;s: A review
Jeffrey Y SunJournal of Anaesthesiology Clinical Pharmacology 2020 36(3):297-302 As early as 1955, it was Bedford who provided description of cognitive changes in elderly patients following anesthesia and surgery. Reports of individuals with catastrophic, non-stroke-related decline in cognitive functions following anesthesia and surgery lead to a perception in the lay population that anesthesia and surgery have the potential to greatly exaggerate the progression of dementia, particularly Alzheimer's disease (AD). There is a concern that anesthesia and surgery could cause irreversible impairment, leading to AD. ...
Source: Journal of Anaesthesiology Clinical Pharmacology - October 16, 2020 Category: Anesthesiology Authors: Jeffrey Y Sun Source Type: research

Preeclampsia and Risk of Dementia Later in Life: A Nationwide Cohort Study
(BMJ. 2018;363:k4109) Vascular dysfunction plays an important role in the pathophysiology of preeclampsia, and women with a history of preeclampsia face an increased risk of other cardiovascular disorders after pregnancy, including hypertension and stroke. Given these associations, women with preeclampsia might also be at increased risk of developing dementia. Previous studies that have investigated the association between hypertensive disorders of pregnancy and dementia later in life have had limitations such as being underpowered and dependent on self-reported information. This current study used a large register-based ...
Source: Obstetric Anesthesia Digest - August 27, 2019 Category: Anesthesiology Tags: Epidemiologic Reports Surveys Source Type: research

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of Pain on Incident Risk of Disability in Elderly Japanese Cause-specific Analysis
This study aimed to investigate the association of pain severity with subsequent functional disability due to all causes as well as stroke, dementia, and joint disease/fracture.Methods The authors conducted a prospective cohort study of 13,702 Japanese individuals aged 65 yr or older. Information regarding pain severity during the previous 4 weeks and other lifestyle factors was collectedvia questionnaire in 2006. Data on the incidence of functional disability were retrieved from the Long-term Care Insurance database. Cox proportional hazards regression analysis was used to estimate the multivariate-adjusted hazard ratios ...
Source: Anesthesiology - March 14, 2017 Category: Anesthesiology Source Type: research

Cochrane Priority Reviews List: December 2016 Update
Cochrane-wide prioritisation remains an important project, with over 140 priority reviews or updates have been published since it began in January 2015.The December 2016 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Airways, Anaesthesia, Dementia& Cognitive Improvement, ENT, Epilepsy, Gynaecological, Neuro-oncology and Orphan Cancers, Gynaecology& Fertility, Haematological Malignancies, Heart, Incontinence, Kidney& Transplant, Lung Cancer, Neuromuscular Disease, Oral Health, Skin, Stroke, and Urology Groups.The following titles on the list are open to new authors:Long-acti...
Source: Cochrane News and Events - December 14, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news

Covert stroke after non-cardiac surgery: a prospective cohort study
Conclusions This international multicentre study suggests that 1 in 10 patients ≥65 yr of age experiences a perioperative covert stroke. A larger study is required to determine the impact of perioperative covert stroke on patient-important outcomes. Clinical trial registration NCT01369537.
Source: British Journal of Anaesthesia - July 19, 2016 Category: Anesthesiology Authors: Mrkobrada, M., Hill, M. D., Chan, M. T. V., Sigamani, A., Cowan, D., Kurz, A., Sessler, D. I., Jacka, M., Graham, M., Dasgupta, M., Dunlop, V., Emery, D. J., Gulka, I., Guyatt, G., Heels-Ansdell, D., Murkin, J., Pettit, S., Sahlas, D. J., Sharma, M., Shar Tags: Clinical Practice Source Type: research

Acute effects of electro-acupuncture (EA) on hippocampal long term potentiation (LTP) of perforant path-dentate gyrus granule cells synapse related to memory.
Authors: He X, Yan T, Chen R, Ran D Abstract Acupuncture, a traditional Chinese therapeutic method, has been widely used in clinical practice to treat diseases such as stroke, Bell's palsy, Alzheimer disease, Parkinson diseases, dysmenorrhea and chronic pain. Mounting lab data had suggested that electro-acupuncture could alleviate dementia and restore long term potentiation of hippocampus in rat. Clinical data also indicated that electro-acupuncture could improve electrical activity of brain in vascular dementia patients. However, its biological basis and acute effects on hippocampal long term potentiation (LTP) re...
Source: Acupuncture and Electro-Therapeutics Research - November 30, 2015 Category: Complementary Medicine Tags: Acupunct Electrother Res Source Type: research

Tactile unawareness in acute right hemispheric stroke (P1.207)
CONCLUSIONS:Tactile unawareness is common in acute right MCA stroke. Bedside findings can help dissociate primary sensory deficit from somatosensory hemi-inattention. The importance of spatial attention in tactile awareness is substantiated by the lesion sites associated with the disorder: regions crucial for multi-sensory integration and bodily awareness. Study Supported by:Disclosure: Dr. Antoniello has nothing to disclose. Dr. Gottesman has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Antoniello, D., Gottesman, R. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Attention and Aphasia Source Type: research

Selective modulators of α5-containing GABAA receptors and their therapeutic significance.
Abstract GABAA receptors containing the α5 subunit (α5GABAARs) are found mainly in the hippocampus where they mediate a tonic chloride leak current and contribute a slow component to GABAergic inhibitory synaptic currents. Their inhibitory effect on the excitability of hippocampal neurons at least partly explains why changes in the level of activity of α5GABAARs affect cognition, learning and memory. These receptors have been implicated as potential therapeutic targets for a range of clinical conditions including age-related dementia, stroke, schizophrenia, Down syndrome and anesthetic-induced amnesia. Accordin...
Source: Current Drug Targets - March 9, 2015 Category: Drugs & Pharmacology Authors: Soh MS, Lynch JW Tags: Curr Drug Targets Source Type: research

Could curry spice boost brain cell repair?
ConclusionThis laboratory and animal research has found that an extract from turmeric (aromatic turmerone) seems to increase the growth and differentiation of neural stem cells (NSCs). However, this research is in the very early stages. So far, the extract has only been added to brain stem cells in the laboratory, or directly injected into the brains of only three rats. Though NSCs have some ability to regenerate brain cells after damage, this is usually not enough to have an effect in degenerative brain diseases such as Alzheimer’s. The hope is that by boosting the number of NSCs, they could be more effective at repairi...
Source: NHS News Feed - September 26, 2014 Category: Consumer Health News Tags: Food/diet Neurology Source Type: news

Test could give two-year warning for Alzheimer's
Conclusion The researchers suggest that Alzheimer's disease can be predicted with an accuracy of 87.5% when thinning of the cortex in the right anterior cingulated gyrus is seen on MRI, alongside test results suggesting problems with recall and recognition. This research does not indicate a new "test", as MRI and psychological testing are standard procedures when investigating the signs and symptoms of dementia. What is novel in this approach is looking at a specific combination of results as a potential way of predicting which people with MCI may develop Alzheimer's disease. While this form of testing would be b...
Source: NHS News Feed - December 9, 2013 Category: Consumer Health News Tags: Neurology Source Type: news