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Source: Neurology
Condition: Dementia

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Total 240 results found since Jan 2013.

MCI subtypes are heterogeneous and preceded by different risk factors: A study on aMCI and naMCI incidence (P4.194)
Conclusions:Results suggested that aMCI and naMCI are inherently heterogeneous from the outset, illustrated by their different risk factors. Recognizing indicators of MCI prior to clinical presentation is critical in targeted interventions, early treatment, and prevention from rapid progression to dementia.Study Supported by:NIA grant: AG03949Sylvia and Leonard Marx FoundationDisclosure: Dr. Zammit has nothing to disclose. Dr. Lipton has received personal compensation from Allergan, American Headache Society, Autonomic Technologies, Boston Scientific, Bristol Myers Squibb, Cognimed, Colucid, Eli Lilly, eNeura Therapeutics,...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zammit, A., Lipton, R., Katz, M., Derby, C., Hall, C. Tags: Behavioral and Cognitive Neurology: Neurodegenerative Disorders Source Type: research

HELIAD study: Dementia prevalence in Greece (P3.095)
Conclusions:The prevalence of dementia and its subtypes in Greece is similar or at the lower range of that reported in many other European countries and globally. In our sample, increased age and decreased level of education status, but not gender, were predictive of a diagnosis of dementia with age being the strongest predictive factor.Study Supported by:Funding/Support: IIRG-09-133014 from the Alzheimer’s Association; 189 10276/8/9/2011 from the ESPA-EU program Excellence Grant (ARISTEIA) which is co-funded by the European Social Fund and Greek National resources; and Y2β/o.51657/14.4.2009 from the Ministry fo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Sakka, P., Kosmidis, M., Yannakoulia, M., Dardiotis, E., Hadjigeorgiou, G., Scarmeas, N. Tags: Aging and Dementia: Epidemiologic Studies Source Type: research

Late treatment with choline alfoscerate increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment (P1.229)
Conclusions:The present study suggests that application of α-GPC after seizure may serve as a beneficial treatment for improvement of cognitive function in epilepsy patientsDisclosure: Dr. Yoo has nothing to disclose. Dr. Shin has nothing to disclose. Dr. Lee has nothing to disclose. Dr. SONG has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Yoo, J., Shin, D. J., Lee, B., SONG, H. Tags: Epilepsy and Clinical Neurophysiology: Basic Science Source Type: research

Probable rapid eye movement sleep behavior disorder and risk of stroke: a prospective study (P4.302)
Conclusions:Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association.Study Supported by: The National Institute of Neurological Disorders And Stroke at the National Institutes of Health (NINDS 5R21NS087235-02 to X.G.)Disclosure: Dr. Ma has nothing to disclose. Dr. Pavlova has received research support from Lundbeck and Biomobie Corporation. Dr. Liu has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Huangfu has nothing to di...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ma, C., Pavlova, M., Liu, Y., Liu, Y., Huangfu, C., Wu, S., Gao, X. Tags: Neuroepidemiology: Cerebrovascular Disease I Source Type: research

Neurofilament light chain as a serum marker for cerebral small vessel disease (P2.096)
Conclusions:In conclusion, serum NFL levels were strongly related to MR-imaging markers as well as clinical and cognitive symptoms of SVD. For disability and dependence there was an added value of serum NFL levels beyond imaging markers. Potentially, serum NFL may serve as a marker of disease burden and progression in SVD.Disclosure: Dr. Duering has nothing to disclose. Dr. Tiedt has nothing to disclose. Dr. Baykara has nothing to disclose. Dr. Lyrer has received personal compensation for activities with Boehringer Ingelheim, Switzerland and Bayer Healthcare, Switzerland as a member of the scientific advisory board. Dr. En...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Duering, M., Tiedt, S., Baykara, E., Lyrer, P., Engelter, S., Gesierich, B., Achmueller, M., Barro, C., Adam, R., Ewers, M., Dichgans, M., Kuhle, J., Peters, N. Tags: Vascular Disease and Dementia Source Type: research

Predicting long term cognitive outcomes after stroke using pre and post-stroke cognitive trajectories. (P2.098)
Conclusions:The rate of decline in cognition after stroke is predicted by rate of decline prior to stroke. Furthermore, greater change in rate of cognitive decline after incident stroke predicts dementia in individuals who were normal at the time of stroke. This may be a marker of both ongoing cerebrovascular injury and underlying neurodegenerative pathology.Disclosure: Dr. Thomas has nothing to disclose. Dr. Mattek has nothing to disclose. Dr. Wild has nothing to disclose. Dr. Dodge has nothing to disclose. Dr. Silbert has received research support from Eli-Lilly. Dr. Kaye has received personal compensation for activities...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Thomas, N., Mattek, N., Wild, K., Dodge, H., Silbert, L., Kaye, J., Erten-Lyons, D. Tags: Vascular Disease and Dementia Source Type: research

Intracranial atherosclerosis and dementia: The Atherosclerosis Risk in Communities (ARIC) Study
Conclusions: This study demonstrates associations between ICAD and clinical MCI and dementia.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Dearborn, J. L., Zhang, Y., Qiao, Y., Suri, M. F. K., Liu, L., Gottesman, R. F., Rawlings, A. M., Mosley, T. H., Alonso, A., Knopman, D. S., Guallar, E., Wasserman, B. A. Tags: MRI, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia ARTICLE Source Type: research

Chronic Blood-Brain Barrier Disruption: a case report (P3.275)
Conclusions:WMH-associated BBB disruption maybe exacerbated by acute stroke, and can persist for months after the initial event, as manifest on BBB permeability imaging. These findings may offer insight into the pathophysiology of vascular dementia.Disclosure: Dr. Naqvi has nothing to disclose. Dr. Hitomi has nothing to disclose. Dr. Leigh has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Naqvi, I., Hitomi, E., Leigh, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Predictive Variables of Cognitive Dysfunction in Patients with Lupus (P1.340)
Conclusions:Duration of disease and low educational level are predictors of CD in patients with SLE. Depression and anxiety did not influence cognitive performance. Although cardiovascular comorbidity is a risk factor for dementia in general population, those variables might play a minor role in SLE patients.Study Supported by:Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and São Paulo Research Foundation (FAPESP) (grant #2015/08833-7) supported this study.Disclosure: Dr. Alessi has nothing to disclose. Dr. Dutra Antonio has nothing to disclose. Dr. Maria has nothing...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Alessi, H., Dutra, L. A., Maria, L., Xavier, P., Couce, P., Kayser, C., Barsottini, O. Tags: CNS Inflammatory Diseases and Differential Diagnosis I Source Type: research

Utilization and Cost Savings of Neuroscience Telemedicine Clinic for State Prison Inmates (P2.182)
Conclusions:General neurology/neurosurgical telemedicine-based clinics can serve the broad spectrum of neuroscience diseases present in the prison system, while minimizing costly and potentially dangerous transfers.Disclosure: Dr. Majersik, MD, MS has nothing to disclose. Dr. Fults, MD has nothing to disclose. Dr. diFrancesco, RN has nothing to disclose. Dr. Wong has nothing to disclose. Dr. Chatwin, MPP has nothing to disclose. Dr. Hannon, MD has nothing to disclose. Dr. Tkach, MD has nothing to disclose. Dr. Shuman III, RN has nothing to disclose. Dr. Bernam, MD has nothing to disclose. Dr. Garden, MD has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Majersik, J., Fults, D., diFrancesco, E., Wong, K.-H., Chatwin, S., Hannon, P., Tkach, A., Shuman, H., Bernam, B., Garden, R. Tags: General Neurology: Practice Improvement and Novel Approaches to Care Source Type: research

Elevated cerebrospinal fluid total Tau levels reflects predominant cortical involvement in Alzheimers disease (P1.093)
Conclusions:Elevated CSF Tau levels in AD patients could be surrogate biomarker for AD subtypes with predominant early cortical symptoms and atrophy. There is a need for a systematic prospective unbiased follow-up to see if rapid clinical progression in AD is related to elevated T-Tau and distinct AD subtypes.Disclosure: Dr. Pillai has nothing to disclose. Dr. Khrestian has nothing to disclose. Dr. Bekris has nothing to disclose. Dr. Safar has nothing to disclose. Dr. Leverenz has received personal compensation for activities with Axovant, GE Healthcare and Navidea Biopharmaceuticals as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pillai, J., Khrestian, M., Bekris, L., Safar, J., Leverenz, J. Tags: Aging and Dementia: Biomarkers Source Type: research

Association between frequency of sleep medication use and brain morphology (P3.058)
Conclusions:This is the first study to examine the association between frequency of sleep medication use and brain morphology in a healthy group of older adults. Metabolic effects or a possible neurotoxicity could play a role to the observed associations.Study Supported by:NIH R01AG038465-02NIH R01AG026158-07Research programs of excellence IKY/SIEMENS for Angeliki Tsapanou, Nikolao ScarmeaDisclosure: Dr. Tsapanou has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Haider has nothing to disclose. Dr. Stern has received personal compensation for activities with Takeda, Axovant, and Eli Lilly and Company as an adviso...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tsapanou, A., Gu, Y., Haider, L., Sakhardande, J., Scarmeas, N., Stern, Y. Tags: Sleep Disruption and Medical Co-Morbidities Source Type: research

Gender Differences in Post Stroke Fatigue (P5.290)
Conclusions:In our urban predominately minority cohort, women had more severe PSF than men. The basis for the protective effect of HTN on PSF severity is unclear and deserves further study.Disclosure: Dr. Balucani has nothing to disclose. Dr. Gilles has nothing to disclose. Dr. Singer has nothing to disclose. Dr. Stefanov has nothing to disclose. Dr. Halket has nothing to disclose. Dr. Mlastabi has nothing to disclose. Dr. Huang has nothing to disclose. Dr. Weingast has nothing to disclose. Dr. Levine has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Balucani, C., Gilles, N., Singer, J., Stefanov, D., Halket, D., Mlastabi, J., Huang, A., Weingast, S., Levine, S. Tags: Stroke Recovery and Rehabilitation Source Type: research

Impaired Recognition of Sadness in Face or Voice Correlates with Spouses Perception of Empathy in Frontotemporal Dementia (P4.184)
Conclusions:At least some patients with bvFTD are impaired in recognizing emotions from facial expressions and prosody, but have spared expression of prosody and understanding of emotional words. Inability to recognize sadness using facial and prosodic cues may underlie spouses’ perception of impaired empathetic concern. Identifying specific deficits in prosody can guide treatment or family counseling.Disclosure: Dr. Phillips has nothing to disclose. Dr. Sutherland-Foggio has nothing to disclose. Dr. Wright has nothing to disclose. Dr. Onyike has received research support from Forest Laboratories, Inc. Dr. Hillis has...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Phillips, L., Sutherland-Foggio, H., Wright, A., Onyike, C., Hillis, A. Tags: Behavioral and Cognitive Neurology: Neurodegenerative Disorders Source Type: research

A Brief Dementia Screening Test in South Africa: Results from the Health and Aging Longitudinal Study of an INDEPTH community (HAALSI) (P4.191)
Conclusions:There is a potentially protective and long-lasting impact of secondary school education on cognitive status later in life in this setting. Using a brief screening test in this relatively poor cohort of older South Africans, patterns of low cognition are similar to those in the USA and other countries.Study Supported by:The National Institute on Aging at the National Institute of Health (NIH) (1P01AG041710-01A1; 1R01AG051144–01; 3U54HG006938-03S1). F. Mateen is supported by a subgrant of P30AG024409 from the NIH for the Harvard Center for Global Demography and Aging. The Agincourt HDSS was supported by the...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mateen, F., Jennings, E., Montana, L., Wagner, R., Kahn, K., Tollman, S., Berkman, L. Tags: Behavioral and Cognitive Neurology: Neurodegenerative Disorders Source Type: research