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Source: Neurology
Condition: Dementia

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Total 240 results found since Jan 2013.

Spectrum of Neurological Disorders Among 19th Century and Early to Mid-20th Century United States Presidents (P6.334)
Conclusion: Neurological conditions are common among presidents of the United States and sometimes have led to catastrophic events. These conditions also had a significant effect on their careers as well as the course of history. Recognizing and understanding the effects of these conditions on past presidency will lead to better management of the tenure of upcoming presidents.Disclosure: Dr. Govindarajan has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Govindarajan, R. Tags: History of Neurology Source Type: research

Individualized neuro-cognitive rehabilitation can reverse cognitive and memory impairment irrespective of etiology: Prospective pilot study (P6.189)
Conclusion: Supervised neurocognitive rehabilitation, specifically designed for individual provides significant reversal of cognitive deficit in adult patients with cognitive impairment, regardless of the etiology.Disclosure: Dr. Kumar has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Jawahar has nothing to disclose. Dr. Kumar has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kumar, S., Kumar, J., Jawahar, A., Kumar, M. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Dementia: Psychosocial Aspects Source Type: research

Demographics and Impact on Diagnosis of Neurological Consultations in the ICU (P5.035)
CONCLUSIONS: The neurology consult service had a measurable impact on diagnosis in ICU patients, changing the diagnosis in 75[percnt], and may, therefore, make an important contribution to management and outcomes of these patients.Disclosure: Dr. Weathered has nothing to disclose. Dr. Lennihan has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Weathered, N., Lennihan, L. Tags: Neuroepidemiology: Aging, Dementia, Cognitive, and Behavioral Neurology, General Neurology, and Research Methodology and Education Source Type: research

Characterization of content specific delusions after right hemispheric ischemic stroke (P6.194)
CONCLUSIONS: CSD occur in approximately one in 9 patients after right hemispheric stroke, are often accompanied by other right hemisphere cognitive disorders with reduplicative paramnesia being the most frequently recorded entity. Long term cognitive impairment is related to regional atrophy.Disclosure: Dr. Dragicevic has nothing to disclose. Dr. Hoffmann has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dragicevic, N., Hoffmann, M. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Neuropsychiatry and Behavioral Neurology Source Type: research

Neural correlates of action recognition and object knowledge in neurodegenerative disease (P6.196)
CONCLUSIONS: Our results suggest that action recognition is supported by a distributed left lateralized functional network that exhibits dissociable roles. In particular, left mid-posterior temporal and inferior parietal areas seem critical for representation of the gestural component of action recognition while frontal inferior regions may support cognitive control requirements common to all 3 tests.Disclosure: Dr. santos has nothing to disclose. Dr. Illan-Gala has nothing to disclose. Dr. Vinceti has nothing to disclose. Dr. Mandelli has nothing to disclose. Dr. Hubbard has nothing to disclose. Dr. Miller has nothing to ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Santos, M., Illan-Gala, I., Vinceti, G., Mandelli, M. L., Hubbard, H., Miller, Z., Rabinovici, G., Miller, B., Gorno Tempini, M. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Neuropsychiatry and Behavioral Neurology Source Type: research

PRISM II: An Open-Label Study to Assess the Safety, Tolerability, and Effectiveness of Dextromethorphan 20 mg/Quinidine 10 mg for Treatment of Pseudobulbar Affect Secondary to Dementia, Stroke, or Traumatic Brain Injury: Results from the Alzheimer's Disease/Dementia Cohort (P7.109)
CONCLUSIONS: DM/Q was generally well tolerated and associated with clinically meaningful PBA symptom reduction rated by patients, caregivers, and clinicians. PBA improvement was consistent with previous controlled trials in patients with PBA due to ALS and MS, supporting DM/Q effectiveness irrespective of PBA etiology. Study supported by: Avanir Pharmaceuticals, Inc.Disclosure: Dr. Doody has received personal compensation for activities with Allon, AC Immune, Accera, AZTherapies, Biote, Cardeus, Chiesi, Genzyme, Hoffman-LaRoche, Merck & Co., Inc., Nutricia,Shire, Sonexa, Suven, Takeda, Toyama, and Zinfandel as a consul...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Doody, R., D'Amico, S., Cutler, A., Shin, P., Ledon, F., Yonan, C., Siffert, J. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Clinical Trials Source Type: research

Regular aspirin use does not reduce risk of incident cognitive decline (P7.117)
CONCLUSIONS: Regular aspirin did not provide a protective association against incident cognitive impairment in a large, biracial, and geographically diverse cohort. Study Supported by: This research project is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service. Disclosure: Dr. Kelley has received personal compensation for activities with Eli Lilly & Co. as a consultant. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kelley, B., McClure, L., Unverzagt, F., Kissela, B., Kleindorfer, D., Howard, G., Wadley, V. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Cardio- and Cerebrovascular Factors in Dementia Source Type: research

Genetic Association Study of Cognitive Performance (P6.209)
CONCLUSIONS: SORL1 encodes an apolipoprotein E receptor, and influences cognitive decline. Decreased expression of SORL1 has been associated with Alzheimer’s disease. Our data support SNPs rs2101756 and rs985421 as possible moderators of age-related episodic memory decline. Study Supported by: NINDS R37 NS029993, Evelyn F. McKnight Brain Institute, ACMG FoundationDisclosure: Dr. Katz has nothing to disclose. Dr. Dong has nothing to disclose. Dr. Stern has received personal compensation for activities with Elan, Bayer Pharmaceuticals Corporation, Cephalon, and GalaxoSmithKlein as a consultant. Dr. Wright has received ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Katz, J., Dong, C., Stern, Y., Wright, C., Blanton, S., Sacco, R. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Cognition and Cognitive Assessment Source Type: research

The Longitudinal Relationship between Inflammatory Burden and Gait Speed is Influenced by White Matter Microstructural Characteristics: Secondary Analysis of the Health ABC Study. (P6.213)
CONCLUSIONS: Sustained exposure to high IL-6 rather than the rate of change in IL-6 may adversely affect walking speed, potentially by influencing WM microstructural characteristics in older adults. Funding: N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, R01-AG028050, R01AG 027017, K07AG033174, R01-NR012459, Pittsburgh Pepper Center (P30 AG024827).Disclosure: Dr. Nadkarni has nothing to disclose. Dr. Boudreau has nothing to disclose. Dr. Lopez has received personal compensation for activities with Merz Pharma as a consultant. Dr. Aizenstein has nothing to disclose. Dr. Kritchevsky has nothing to disclose. Dr. Yaffe has recei...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Nadkarni, N., Boudreau, R., Lopez, O., Aizenstein, H., Kritchevsky, S., Yaffe, K., Studenski, S., Newman, A., Rosano, C. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: White Matter and Diffusion Imaging Source Type: research

Altered resting-state network connectivity in stroke patients with and without apraxia of speech (S49.002)
CONCLUSIONS: These results highlight the left PM region’s involvement in AOS, begin to differentiate it’s neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming following stroke. Study Supported by: National Health and Medical Research Council Project Grant 632763Disclosure: Dr. New has nothing to disclose. Dr. Kirrie has nothing to disclose. Dr. Parkinson has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. McNeil has nothing to disclose. Dr. Piguet has nothing to disclose. Dr....
Source: Neurology - April 8, 2015 Category: Neurology Authors: New, A., Kirrie, B., Parkinson, A., Duffy, J., McNeil, M., Piguet, O., Hornberger, M., Price, C., Eickhoff, S., Robin, D. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Imaging: Behavioral Neurology and non-Alzheimer ' s Disease Dementias Source Type: research

Atrial Fibrillation in Patients with Neuropathological Diagnosis of Primary Alzheimer's Disease (S16.002)
CONCLUSIONS: AF-AD has a more "vascular" and "benign" profile than nAF-AD. Dementia seems to be mediated by brain infarcts rather than by neurodegeneration. FUNDING:National Institute on Aging (UO1 AG016976).Disclosure: Dr. Riccio has nothing to disclose. Dr. Sposato has nothing to disclose. Dr. Ruiz Vargas has nothing to disclose. Dr. Toledo has nothing to disclose. Dr. Trojanowski has received personal compensation for activities with Johnson & Johnson. Dr. Hachinski has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Riccio, P., Sposato, L. A., Ruiz Vargas, E., Toledo, J., Trojanowski, J., Hachinski, V. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Clinical Science Source Type: research

An Unusual Case Of Cadasil With Occipital Lobe Involvement (P6.006)
CONCLUSION: We discuss the unique features of a rare case of occipital lobe predominant CADASIL lacking the typical anterior temporal lobe involvement. This case exemplifies the heterogeneity of clinical findings that may be associated with NOTCH3 mutations.Disclosure: Dr. Mishra has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Flippen has received personal compensation for activities with MAP Pharmaceuticals/Allergan. Dr. Flippen has received personal compensation in an editorial capacity for the Journal of Graduate Medical Education and Up-To-Date. Dr. Flippen has received Dr. Fogel has received personal com...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Mishra, S., Rao, N., Flippen, C., Fogel, B., Hathout, G., Thomas, M., Kattan, J., Trikamji, B. Tags: Treatments, Therapeutics, and Biomarkers Poster Discussion Session Source Type: research

Physical activity, motor function, and white matter hyperintensity burden in healthy older adults
Conclusions: Higher levels of physical activity may reduce the effect of WMH burden on motor function in healthy older adults.
Source: Neurology - March 30, 2015 Category: Neurology Authors: Fleischman, D. A., Yang, J., Arfanakis, K., Arvanitakis, Z., Leurgans, S. E., Turner, A. D., Barnes, L. L., Bennett, D. A., Buchman, A. S. Tags: MRI, All Clinical Neurology, All Cerebrovascular disease/Stroke, Motor Control, Cohort studies ARTICLE Source Type: research

Effects of vascular risk factors and APOE {varepsilon}4 on white matter integrity and cognitive decline
Conclusions: Vascular risk factors are associated with reduced white matter integrity among older adults, which subsequently predicted faster cognitive decline. The detrimental effects of vascular risk factors on white matter microstructure were exacerbated among APOE 4 carriers.
Source: Neurology - March 16, 2015 Category: Neurology Authors: Wang, R., Fratiglioni, L., Laukka, E. J., Lovden, M., Kalpouzos, G., Keller, L., Graff, C., Salami, A., Backman, L., Qiu, C. Tags: MRI, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Subclinical cardiac dysfunction increases the risk of stroke and dementia: The Rotterdam Study
Conclusions: In elderly free of clinical cardiac disease, worse diastolic function is associated with clinical stroke, dementia, and silent infarcts on MRI, whereas worse systolic function is related only to clinical stroke. These findings can form the basis for future research on the utility of cardiac function as potential intervention target for prevention of neurologic diseases.
Source: Neurology - February 23, 2015 Category: Neurology Authors: de Bruijn, R. F. A. G., Portegies, M. L. P., Leening, M. J. G., Bos, M. J., Hofman, A., van der Lugt, A., Niessen, W. J., Vernooij, M. W., Franco, O. H., Koudstaal, P. J., Ikram, M. A. Tags: MRI, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, Cohort studies ARTICLE Source Type: research