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Source: Neurology
Condition: Dementia

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Total 240 results found since Jan 2013.

Strategic white matter tracts for processing speed deficits in age-related small vessel disease
Conclusions: Our findings highlight damage to frontal interhemispheric and thalamic projection fiber tracts harboring frontal-subcortical neuronal circuits as a predictor for processing speed performance in age-related small vessel disease.
Source: Neurology - June 2, 2014 Category: Neurology Authors: Duering, M., Gesierich, B., Seiler, S., Pirpamer, L., Gonik, M., Hofer, E., Jouvent, E., Duchesnay, E., Chabriat, H., Ropele, S., Schmidt, R., Dichgans, M. Tags: MRI, Other cerebrovascular disease/ Stroke, Volumetric MRI, Vascular dementia, Cognitive aging ARTICLE Source Type: research

Antemortem MRI findings associated with microinfarcts at autopsy
Conclusions: Microinfarcts increase brain atrophy rates independent of Alzheimer disease pathology. Association between microinfarct pathology and macroinfarcts on MRI suggests either common risk factors or a shared pathophysiology and potentially common preventive targets.
Source: Neurology - June 2, 2014 Category: Neurology Authors: Raman, M. R., Preboske, G. M., Przybelski, S. A., Gunter, J. L., Senjem, M. L., Vemuri, P., Murphy, M. C., Murray, M. E., Boeve, B. F., Knopman, D. S., Petersen, R. C., Parisi, J. E., Dickson, D. W., Jack, C. R., Kantarci, K. Tags: MRI, Volumetric MRI, All Cerebrovascular disease/Stroke, Alzheimer's disease, Infarction ARTICLE Source Type: research

Emerging Subspecialties in Neurology: Neuropalliative care
Palliative medicine, as defined by World Health Organization, is the specialty that recognizes and attempts to prevent or alleviate physical, social, psychological, and spiritual suffering.1 Understanding the principles of palliative care should be an essential component of neurologic training, as the trajectory of many neurologic illnesses is progressive and incurable.2 Given the delicate nature of many of the conversations that neurologists have with patients at the time of diagnosis or during acute illness and hospitalization, expertise in discussing a patient's wishes, handling difficult conversations, and providing ad...
Source: Neurology - May 26, 2014 Category: Neurology Authors: Robinson, M. T., Barrett, K. M. Tags: Palliation pain, Palliative care RESIDENT AND FELLOW SECTION Source Type: research

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy
Conclusion: Lower serum levels of IGF-1 are associated with an increased risk of developing AD dementia and higher levels with greater brain volumes even among middle-aged community-dwelling participants free of stroke and dementia. Higher levels of IGF-1 may protect against subclinical and clinical neurodegeneration.
Source: Neurology - May 5, 2014 Category: Neurology Authors: Westwood, A. J., Beiser, A., DeCarli, C., Harris, T. B., Chen, T. C., He, X.-m., Roubenoff, R., Pikula, A., Au, R., Braverman, L. E., Wolf, P. A., Vasan, R. S., Seshadri, S. Tags: MRI, Endocrine, Alzheimer's disease, Cohort studies ARTICLE Source Type: research

Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities
Conclusions: The small effect of VRFs and LAD on WMH suggests that WMH have a large "nonvascular," nonatheromatous etiology. VRF modification, although important, may be limited in preventing WMH and their stroke and dementia consequences. Investigation of, and interventions against, other suspected small-vessel disease mechanisms should be addressed.
Source: Neurology - April 14, 2014 Category: Neurology Authors: Wardlaw, J. M., Allerhand, M., Doubal, F. N., Valdes Hernandez, M., Morris, Z., Gow, A. J., Bastin, M., Starr, J. M., Dennis, M. S., Deary, I. J. Tags: Stroke prevention, MRI, Vascular dementia, Risk factors in epidemiology ARTICLE Source Type: research

Striatal and Extrastriatal Dopamine Transporter Levels Relate to Cognition in Lewy Body Diseases (P2.009)
CONCLUSIONS: Caudate and extrastriatal dopamine dysfunction contribute in opposing directions to cognitive impairment in DLB.Study Supported by: Michael J. Fox Foundation (SNG, JHG.), National Alzheimer’s Coordinating Center Collaborative Project 5 U01 AG016976-11 (SNG, KAJ, JHG), the National Institute of Neurological Disorders and Stroke (KAJ), the National Institute on Aging (KAJ,TH), the Alzheimer’s Disease Association (KAJ), the Caja Madrid Foundation scholarship for postgraduate studies (MM), the Harvard Center for Neurodegeneration and Repair Pilot grant (SNG). Randy L. Buckner contributed to this study:...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gomperts, S., Marquie Sayagues, M., Locascio, J., Rentz, D., Becker, A., Hedden, T., Johnson, K., Growdon, J. Tags: Movement Disorders II Source Type: research

Impact of Stroke on A{beta}1-40 and A{beta}1-42 Plasmatic Levels (P1.105)
Conclusion. Aβ1-40 levels depend mainly on stroke characteristics, especially delay after onset, vascular risk factors and ischemic subtype, but not by PCoI. Aβ1-42 levels are not influenced by stroke, but their relationship with the cognitive status is more difficult to interpret.Disclosure: Dr. Moulin has nothing to disclose. Dr. Leys has received personal compensation in an editorial capacity for Lancet and Lancet Neurology. Dr. Leys has received research support from Bayer Pharmaceuticals Corp., Sanofi-Aventis Pharmaceuticals Inc., and Boehringer Ingelheim Pharmaceuticals Inc. Dr. Schraen-Maschke has nothing ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Moulin, S., Leys, D., Schraen-Maschke, S., Bordet, R. Tags: Cerebrovascular Disease and Interventional Neurology: Translational Science Source Type: research

The Utilization of Forced Aerobic Exercise to Augment the Recovery of Motor Function Following Stroke: A Randomized Clinical Trial (P2.016)
CONCLUSIONS: Patients with chronic stroke can safely participate in intensive aerobic exercise. FE is a novel and efficacious intervention that can improve cardiovascular health and may augment the recovery of UE motor function post-stroke.Disclosure: Dr. Linder has received research support from the National Institutes of Health. Dr. Rosenfeldt has nothing to disclose. Dr. Penko has nothing to disclose. Dr. Alberts has received personal compensation for activities with Boston Scientific Corporation, Juniper Health Systems, and I1 Biometrics. Dr. Alberts has received research support from the National Institutes of Health,...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Linder, S., Rosenfeldt, A., Penko, A., Alberts, J. Tags: Cerebrovascular Disease and Interventional Neurology I Source Type: research

Comorbidities and Causes of Death in a Cohort of 205 Patients with Parkinsonism (P2.057)
Conclusion: Pneumonia remains the commonest cause of death in patients with parkinsonism. Most patients have different forms of treatable comorbidites and PD is underreported on DC.Disclosure: Dr. Moscovich has nothing to disclose. Dr. Boschetti has nothing to disclose. Dr. Moro has nothing to disclose. Dr. Teive has nothing to disclose. Dr. Munhoz has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Moscovich, M., Boschetti, G., Moro, A., Teive, H., Munhoz, R. Tags: Movement Disorders: Co-morbidities and Novel Care Models Source Type: research

Cerebral Amyloid Angiopathy Related Inflammation: Case Reports and Imaging Pitfalls (P2.105)
CONCLUSIONS:CAA-I can be identified by characteristic MRI findings, and evidence of microbleeds in the presence of inflammation is supportive of the diagnosis in the right clinical picture. Both cases were clinically consistent with CAA-I, presenting with subacute cognitive changes. Commonly available imaging techniques such as gradient echo -T2* may not be sensitive enough to reliably make the diagnosis. Our first case reveals that SWI was needed to make the diagnosis of CAA-I. The sensitivity of different imaging sequences should be weighed when considering the diagnosis, particularly as this affects both prognosis and t...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Mcallister, M., Armstrong, M. Tags: Cerebrovascular Disease and Interventional Neurology: Acquired and Congenital Vascular Malformations Source Type: research

Undiagnosed Cognitive Impairment among Patients Referred for Carotid Doppler Evaluation Is Associated with Increased Non-Adherence with Medical Treatment of Vascular Risk Factors (P2.115)
CONCLUSIONS: Non-adherence to medications treating vascular risk factors in patients referred for carotid Doppler evaluation is more common in those with compared to those without cognitive impairment. The association between cognitive impairment and medication non-adherence suggests that cognitive screening may identify a subgroup of patients at higher risk for future cerebrovascular events that would benefit from increased supervision to improve medication adherence.Study Supported by: Department of Veterans Affairs Merit (Award 1I01CX000340) and 2011 VISN 16 grantsDisclosure: Dr. Kirkpatrick has nothing to disclose. Dr....
Source: Neurology - April 9, 2014 Category: Neurology Authors: Kirkpatrick, A., Guthery, L., Prodan, C. Tags: Cerebrovascular Disease and Interventional Neurology: Behavioral, Cognitive, and Miscellaneous Source Type: research

Direct Actions of Granulocyte-Colony Stimulating Factor on Human Neuronal and Monocytic Cell Lines (P1.242)
Conclusions: The cellular and molecular responses to G-CSF treatment of monocytic cells suggest that neither changes in adhesiveness nor migratory capacity are responsible for the beneficial effects of G-CSF administration in models of neurologic diseases. G-CSF induction of anti-apoptotic signaling in neurons is an important component of its neuroprotective effects in models of brain injury.Disclosure: Dr. Sava has nothing to disclose. Dr. Song has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Sanchez-Ramos has received personal compensation for activities with Lundbeck and Teva Neuroscience.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pennington, A., Sava, V., Song, S., Patel, N., Sanchez-Ramos, J. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Basic Science Source Type: research

Impaired Processing of Positive and Negative Facial Expressions in Right Hemisphere Stroke (P2.159)
CONCLUSIONS: Patients with RH stroke had impaired ability to process facial expressions relative to controls.Patients with lesions in the right amygdala and right anterior insula demonstrated particular difficulty processing specific facial expressions. Results suggest that these patients have difficulty recognizing the emotions of others which can impair social interactions, indicating a target for novel interventions.Study supported by: NINDS, R01NS047691.Disclosure: Dr. Tippett has nothing to disclose. Dr. Davis has nothing to disclose. Dr. Gomez has nothing to disclose. Dr. Trupe has nothing to disclose. Dr. Hillis has...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Tippett, D., Davis, C., Gomez, Y., Trupe, L., Hillis, A. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Emotion Source Type: research

Nonverbal Oral Apraxia in Primary Progressive Aphasia and Apraxia of Speech (P2.166)
CONCLUSIONS:We have shown that AOS, NVOA and IMA are at least partially distinct among patients with PPA and PPAOS. NVOA might be more common in patients with AOS due to the proximity of the region we identified by VBM to the premotor area, which has been implicated in AOS. The association of IMA and NVOA among patients without AOS could represent disruption of a module shared by nonverbal oral movements and limb movements.Study Supported by: NIH grant R01-DC010367Disclosure: Dr. Botha has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. Strand has nothing to disclose. Dr. Whitwell has nothing to disclose. Dr. J...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Botha, H., Duffy, J., Strand, E., Whitwell, J., Josephs, K. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: General Cognition Source Type: research

Mild Cognitive Impairment: Neuropsychiatric Symptom Prevalence Within Cognitive Subtypes And Obesity (P2.177)
CONCLUSION: Early behavioral changes in MCI were highest among mdMCI and OB subjects. Continuing work focuses on imaging correlates of behavioral changes in cognitive subtypes and BMI groups in MCI, and longitudinal outcomes.Disclosure: Dr. Hannah has nothing to disclose. Dr. Bozoki has received research support from Elan Corporation, and Wyeth Pharmaceuticals.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hannah, A., Bozoki, A. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: General Cognition Source Type: research