• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Pharmacogenomics and tailored polypharmacy: an 80-year-old lady with rosuvastatin-associated rhabdomyolysis and maprotiline-related Ogilvie's syndrome 
.
We present a unique case of synchronous rhabdomyolysis and Ogilvie's syndrome in an 80-year-old lung cancer survivor following a recent ischemic stroke for which she was prescribed clopidogrel and rosuvastatin for secondary prevention, and maprotiline for post-stroke, new-onset insomnia and anxiety. The ADRs resolved on removal of the offending agents and initiation of conservative treatment. Retrospective pharmacogenetic testing of the patient's drug-metabolizing enzymes and transporters was performed to guide further management and prevent future potential drug interactions and ADRs. What is novel and conclusions: This i...
Source: International Journal of Clinical Pharmacology and Therapeutics - March 5, 2017 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Characteristics of patients treated with nicotine replacement therapy (NRT) prescribed during hospitalization
Conclusions: The follow-up after discharge in specialized units of tobacco cessation is very low, yet the efficacy of the treatment per year was high.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Perez Morales, M., Espana Dominguez, C., Morales Gonzalez, M., Munoz Ramirez, I., Merino Sanchez, M., Arnedillo Munoz, A. Tags: Tobacco, smoking control and health educ. Source Type: research

Autoimmune gabab antibody encephalitis associated with non-malignant lung lesion
GABAb receptor autoimmune encephalitis is a potentially treatable disorder characterised by seizures, memory deficits, increased anxiety and mood dysregulation. In some patients it is associated with small–cell lung cancer and with other autoantibodies. We are presenting a case of GABAb receptor autoimmune encephalitis which was associated with non–malignant lung lesion, likely inflammatory in nature. A 62 year old woman presented with recent onset depression and tonic–clonic seizures. CT head showed patchy white matter changes particularly in the left frontal lobe. Initial treatment for suspected infecti...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Wysota, B., Teare, L., Karim, A., Jacob, S. Tags: Immunology (including allergy), Epilepsy and seizures, Infection (neurology), Stroke, Drugs: psychiatry, Memory disorders (psychiatry), Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics) Association of British Neurologists (AB Source Type: research

Role of respondents' education as a mediator and moderator in the association between childhood socio-economic status and later health and wellbeing
Conclusions: Childhood financial conditions have a unique direct effect on a wide range of health and wellbeing measures. These findings apply to both men and women. Generally, parental education has an indirect effect on later health, but mothers' education may also have a long-term direct effect on later health.
Source: BioMed Central - November 18, 2014 Category: Journals (General) Authors: Mashhood Ahmed SheikhBirgit AbelsenJan Abel Olsen Source Type: research

Five-year 'death test' for older adults launched online
Conclusion This large study has identified numerous risk factors associated with a person's risk of death within five years. Researchers used this information to develop an online tool that predicts someone's risk of death within the next five years. The study's strengths include its large sample size and the prospective nature of the study design. But there are some limitations. There may be some bias in the type of people who volunteered to take part. The death rate was lower than that of the average population in this age group, which may indicate that the participants were more interested in their health and so had he...
Source: NHS News Feed - June 4, 2015 Category: Consumer Health News Tags: Heart/lungs Cancer Lifestyle/exercise Medical practice Source Type: news

Disparities in US Healthcare Provider Screening and Advice for Cessation Across Chronic Medical Conditions and Tobacco Products
ConclusionsResults support the need for provider training to expand screening and cessation interventions to include the growing spectrum of tobacco products. Screening and referral to interventions are especially needed for those with mental health and substance use disorders to reduce the disparate burden of tobacco-related disease and death.
Source: Journal of General Internal Medicine - May 3, 2017 Category: Internal Medicine Source Type: research

Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients.
This study aimed to generate real-world evidence to assess the burden of comorbidities in COPD patients, to effectively manage these patients and optimize the associated healthcare resource allocation. ARCTIC is a large, real-world, retrospective cohort study conducted in Swedish COPD patients using electronic medical record data collected between 2000 and 2014. These patients were studied for prevalence of various comorbidities and for association of these comorbidities with exacerbations, mortality, and healthcare costs compared with an age-, sex-, and comorbidities-matched non-COPD reference population. A total of 17,47...
Source: Primary Care - September 10, 2018 Category: Primary Care Authors: Ställberg B, Janson C, Larsson K, Johansson G, Kostikas K, Gruenberger JB, Gutzwiller FS, Jorgensen L, Uhde M, Lisspers K Tags: NPJ Prim Care Respir Med Source Type: research

Late Breaking Abstract - Inhaled corticosteroids (ICS), blood eosinophils (EOS), and FEV1 decline in patients with Chronic Obstructive Pulmonary Disease in a large UK primary healthcare setting
Conclusions: Regardless of blood EOS level, ICS-containing medication is associated with slower rates of FEV1 decline in COPD patients.Funding: GSK study 208602
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Whittaker, H., Mullerova, H., Jarvis, D., Barnes, N., Jones, P., Compton, C., Kiddle, S., Quint, J. Tags: Epidemiology Source Type: research

Exercise as a Prescription for Patients with Various Diseases
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - April 20, 2019 Category: Sports Medicine Source Type: research

Inflammatory effects of particulate matter air pollution.
Abstract Air pollution is an important cause of non-communicable diseases globally with particulate matter (PM) as one of the main air pollutants. PM is composed of microscopic particles that contain a mixture of chemicals and biological elements that can be harmful to human health. The aerodynamic diameter of PM facilitates their deposition when inhaled. For instance, coarse PM having a diameter of < 10 μm is deposited mainly in the large conducting airways, but PM of < 2.5 μm can cross the alveolar-capillary barrier, traveling to other organs within the body. Epidemiological studies have shown the ...
Source: Environmental Science and Pollution Research International - August 31, 2020 Category: Environmental Health Authors: Arias-Pérez RD, Taborda NA, Gómez DM, Narvaez JF, Porras J, Hernandez JC Tags: Environ Sci Pollut Res Int Source Type: research

Anxiety, Depression, Psychological Symptoms, Negative Effects, and Other Symptoms of Nicotine Withdrawal
This case occurred in a 33-year-old man who has been smoking for 19 years. He had a pattern of consuming 14 cigarettes per day with 30 mg of nicotine intake and high tar levels. The level of tolerance for consumption of nicotine and tar per day is 10 to 15 mg. High cigarette consumption correlates with high nicotine consumption as well. Excessive nicotine consumption over a long period can lead to lung cancer, stroke, heart disease, chronic obstructive pulmonary disease, and psychological disorders.
Source: Addictive Disorders and Their Treatment - November 25, 2021 Category: Addiction Tags: Case Reports Source Type: research