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Impact of frailty models on the prescription of oral anticoagulants and on the incidence of stroke, bleeding, and mortality in older patients with atrial fibrillation: a systematic review
CONCLUSIONS: Due to the great heterogeneity among different validated frailty measures, indiscriminately relying on "frailty" should not be regarded as the gold standard for clinical decision-making about stroke prevention in older AF patients. Present findings suggest that severe frailty according to the DAM is associated with less use of OAT and increased risk of all-cause mortality, thereby representing at the moment the most reasonable tool to efficiently recognize patients with limited life expectancy and for whom there is so far scant, if any, evidence of a clinical benefit of OAT.AVAILABILITY OF DATA AND MATERIAL: A...
Source: Ageing Research Reviews - October 21, 2022 Category: Genetics & Stem Cells Authors: Roberto Presta Enrico Brunetti Maria Cristina Polidori Mario Bo Source Type: research

Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
Apixaban is a direct oral anticoagulant, a factor Xa inhibitor, used for the prevention of ischemic stroke in patients with atrial fibrillation. Despite using recommended dosing a few patients might still experience bleeding or lack of efficacy that might be related to inappropriate drug exposure. We conducted a genome-wide association study using data from 1,325 participants in the pivotal phase three trial of apixaban with the aim to identify genetic factors affecting the pharmacokinetics of apixaban. A candidate gene analysis was also performed for pre-specified variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SULT1A1, wit...
Source: Frontiers in Genetics - September 14, 2022 Category: Genetics & Stem Cells Source Type: research

Frailty Prevalence and Impact on Outcomes in Patients with Atrial Fibrillation: A Systematic Review and Meta-Analysis of 1,187,000 Patients
Ageing Res Rev. 2022 May 31:101652. doi: 10.1016/j.arr.2022.101652. Online ahead of print.ABSTRACTFrailty is a clinical syndrome characterized by a reduced physiologic reserve, increased vulnerability to stressors and an increased risk of adverse outcomes. People with atrial fibrillation (AF) are often burdened by frailty due to biological, clinical, and social factors. The prevalence of frailty, its management and association with major outcomes in AF patients are still not well quantified. We systematically searched PubMed and EMBASE, from inception to September 13th, 2021, for studies reporting the prevalence of frailty...
Source: Ageing Research Reviews - June 6, 2022 Category: Genetics & Stem Cells Authors: Marco Proietti Giulio Francesco Romiti Valeria Raparelli Igor Diemberger Giuseppe Boriani Laura Adelaide Dalla Vecchia Giuseppe Bellelli Emanuele Marzetti Gregory Yh Lip Matteo Cesari Source Type: research

Neurovascular abnormalities in patients with Loeys-Dietz syndrome type III
In conclusion, neurovascular imaging in Loeys Dietz syndrome type III patients revealed abnormalities such as aneurysm, tortuosity, coiling and kinking in the vast majority of patients, but clinical events were rare. Neurovascular screening and follow up is advised in all Loeys Dietz syndrome type III patients.PMID:35031499 | DOI:10.1016/j.ejmg.2022.104424
Source: European Journal of Medical Genetics - January 15, 2022 Category: Genetics & Stem Cells Authors: Silvy Dekker Carlijn G E Thijssen Denise Vd Linde Ingrid M B H Vd Laar Jasper J Saris Adriaan C G M van Es Pieter-Jan van Doormaal Paul van Bronswijk Fop van Kooten Jolien W Roos-Hesselink Source Type: research

Phenotypic Delineation of the Retinal Arterial Macroaneurysm with Supravalvular Pulmonic Stenosis (RAMSVPS) Syndrome.
This article is protected by copyright. All rights reserved. PMID: 31730227 [PubMed - as supplied by publisher]
Source: Clinical Genetics - November 14, 2019 Category: Genetics & Stem Cells Authors: Alkuraya H, Patel N, Ibrahim N, Al Ghamdi B, Alsulaiman SM, Nowilaty SR, Abboud E, Alturki R, Alkharashi A, Eyaid W, Almasseri Z, Alzaidan H, Alotaibi MD, Abu El-Asrar AM, Alamro B, Helaby R, Elshaer A, Almontashiri NAM, Al-Hussaini AA, Alkuraya FS Tags: Clin Genet Source Type: research

Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research

GSE66724 Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Contributors : Mikel Allende ; José HermidaSeries Type : Expression profiling by arrayOrganism : Homo sapiensAtrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administered. Here, microarray analysis in peripheral blood cells in eight patients with AF and stroke and eight AF subjects without stroke identified a stroke related gene expression pattern. HSPA1B, which encodes for heat-shock ...
Source: GEO: Gene Expression Omnibus - April 1, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research