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Specialty: Surgery
Condition: Bleeding

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Total 190 results found since Jan 2013.

Systematic Review and Meta-Analysis of Dual Versus Single Antiplatelet Therapy in Carotid Interventions
Dual antiplatelet therapy demonstrates advantages over single therapy only in patients treated with a carotid artery stent as determined by a decrease risk of transient ischemia attack. Dual therapy was associated with an increased risk of major bleeding, neck hematoma and MI in those undergoing carotid endarterectomy with no benefit regarding protection from transient ischemic attack (TIA)/stroke/mortality.
Source: Journal of Vascular Surgery - February 22, 2017 Category: Surgery Authors: M. Barkat, S. Hajibandeh, S. Hajibandeh, F. Torella, G.A. Antoniou Tags: Abstract Source Type: research

Systemic thrombolysis increases hemorrhagic stroke risk without survival benefit compared with catheter-directed intervention for the treatment of acute pulmonary embolism
Conclusions ST for acute PE may not improve in-hospital mortality compared with CDI but increases the overall risk of hemorrhagic stroke compared with CDI. Further prospective studies should examine the comparative effectiveness and safety of these two treatments.
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - January 15, 2017 Category: Surgery Source Type: research

Carotid Stenting Prior to Coronary Bypass Surgery: An Updated Systematic Review and Meta-Analysis.
CONCLUSIONS: In a cohort of predominantly asymptomatic patients with unilateral carotid stenoses, the 30-day rate of death/stroke was about 8%. Notwithstanding the effect of potential biases, this meta-analysis did not find evidence that outcomes after same-day CAS + CABG were higher than after staged interventions. However, outcomes were poorer in neurologically symptomatic patients. More data are required to establish the optimal antiplatelet strategy in patients undergoing same-day or staged CAS + CABG. PMID: 28094166 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - January 12, 2017 Category: Surgery Authors: Paraskevas KI, Nduwayo S, Saratzis AN, Naylor AR Tags: Eur J Vasc Endovasc Surg Source Type: research

Prevention of Stroke With Ticagrelor in Patients With Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction)
In patients with prior myocardial infarction, ticagrelor 60  mg twice daily reduces risk of stroke without an excess of hemorrhagic stroke but with more major bleeding.
Source: Journal of Vascular Surgery - December 20, 2016 Category: Surgery Authors: M.P. Bonaca, S. Goto, D.L. Bhatt Tags: Abstract Source Type: research

Implementation of goal-directed fluid therapy during hip revision arthroplasty: a matched cohort study
ConclusionsIn patients undergoing hip revision arthroplasty, the implementation of GDT as a new standard operating procedure was successful and associated with reduced postsurgical complications, most importantly a reduction in postoperative bleeding as well as hospital and ICU stay.Trial registrationClinicalTrials.gov,NCT01753050
Source: Perioperative Medicine - December 12, 2016 Category: Surgery Source Type: research

Could advanced drug delivery systems be the future in cardiovascular revascularization medicine?
Abstract Acute myocardial infarction, stroke and pulmonary embolism required a prompt revascularization to restore the normal blood flow as soon as possible. Fibrinolytic treatment has gradually become both dated and underused in the treatment of acute myocardial infarction, after the wide diffusion of cathlab and percutaneous transluminal coronary angioplasty. Conversely, the use of systemic thrombolysis remained a benchmark in the treatment of both ischemic stroke and massive pulmonary embolism. In daily clinical practice, the use of thrombolytic agents is often limited by absolute and/or relative contraindicati...
Source: Vascular - December 5, 2016 Category: Surgery Authors: Zuin M, Rigatelli G, Faggian G, L'Erario R, Chinaglia M, Roncon L Tags: Vascular Source Type: research

Systematic Review and Meta-analysis of Dual Versus Single Antiplatelet Therapy in Carotid Interventions.
CONCLUSIONS: Dual antiplatelet therapy demonstrates advantages over single therapy only in CAS, as indicated by a reduced risk of TIA. Dual antiplatelet therapy was associated with an increased risk of bleeding complications in patients undergoing CEA. PMID: 27894896 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - November 25, 2016 Category: Surgery Authors: Barkat M, Hajibandeh S, Hajibandeh S, Torella F, Antoniou GA Tags: Eur J Vasc Endovasc Surg Source Type: research

Protamine Reduces Bleeding Complications without Increasing the Risk of Stroke after Carotid Endarterectomy: A Meta-analysis
The aim was to evaluate the safety and efficacy of heparin reversal with protamine after completion of carotid endarterectomy (CEA), summarising the available data from both randomised and non-randomised studies.
Source: Journal of Vascular Surgery - September 22, 2016 Category: Surgery Authors: J.D. Kakisis, C.N. Antonopoulos, K.G. Moulakakis, F. Schneider, G. Geroulakos, J.B. Ricco Tags: Selected abstract from the September issue of the European Journal of Vascular and Endovascular Surgery Source Type: research

Efficacy and safety of rivaroxaban thromboprophylaxis after arthroplasty of the hip or knee: retrospective cohort study.
Conclusions Rivaroxaban is an effective and safe anticoagulant for thromboprophylaxis after hip arthroplasty or knee arthroplasty if used in a modified regimen involving enoxaparin administered in the inpatient setting followed by rivaroxaban upon hospital discharge. PMID: 27580310 [PubMed - in process]
Source: Annals of the Royal College of Surgeons of England - August 31, 2016 Category: Surgery Authors: Loganathan L, Hua A, Patel S, Gibbons C, Vizcaychipi MP Tags: Ann R Coll Surg Engl Source Type: research

Drain Placement Confers No Benefit Following Carotid Endarterectomy in the Vascular Quality Initiative
Whereas bleeding complications requiring a return to the operating room (OR) after carotid endarterectomy (CEA) are infrequent (1%), they are associated with increased 30-day combined postoperative stroke/death rate. Drain placement (DR) after CEA varies among vascular surgeons, and there are limited data to support the practice. The goal of this study was to evaluate factors leading to DR and the effect of DR on postoperative outcomes including return to OR for bleeding, stroke, and death.
Source: Journal of Vascular Surgery - August 23, 2016 Category: Surgery Authors: Christopher J. Smolock, Jeanwan Kang, James F. Bena, Nayara Cioffi Batagini, Rebecca Kelso, Daniel Clair Tags: Abstract from the 2016 Eastern Vascular Society Annual Meeting Source Type: research

Commentary on ‘Protamine Reduces Bleeding Complications Without Increasing the Risk of Stroke After Carotid Endarterectomy: A Meta-analysis’
Kakisis et  al. demonstrate in their meta-analysis that reversing the effect of heparin with protamine seems to reduce the number of major neck hematomas associated with CEA. One might fear that this would be at the cost of an increased level of cerebral thromboembolism. However, Kakisis et al. showed that a dministration of protamine does not seem to influence the rate of stroke.1
Source: European Journal of Vascular and Endovascular Surgery - July 13, 2016 Category: Surgery Authors: L.K. Rathenborg Tags: Invited Commentary Source Type: research

Commentary on 'Protamine Reduces Bleeding Complications Without Increasing the Risk of Stroke After Carotid Endarterectomy: A Meta-analysis'.
PMID: 27424007 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - July 12, 2016 Category: Surgery Authors: Rathenborg LK Tags: Eur J Vasc Endovasc Surg Source Type: research

Protamine Reduces Bleeding Complications without Increasing the Risk of Stroke after Carotid Endarterectomy: A Meta-analysis
The aim was to evaluate the safety and efficacy of heparin reversal with protamine after completion of carotid endarterectomy (CEA), summarising the available data from both randomised and non-randomised studies.
Source: European Journal of Vascular and Endovascular Surgery - July 3, 2016 Category: Surgery Authors: J.D. Kakisis, C.N. Antonopoulos, K.G. Moulakakis, F. Schneider, G. Geroulakos, J.B. Ricco Tags: Review Source Type: research

Protamine Reduces Bleeding Complications without Increasing the Risk of Stroke after Carotid Endarterectomy: A Meta-analysis.
CONCLUSION: On the basis of the available data, heparin reversal with protamine seems to reduce the risk of wound haematoma, without increasing the risk of procedural stroke. However, taking into account the limitations of the analysis, further studies are needed to increase the level of evidence provided by the current meta-analysis. PMID: 27389942 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - July 3, 2016 Category: Surgery Authors: Kakisis JD, Antonopoulos CN, Moulakakis KG, Schneider F, Geroulakos G, Ricco JB Tags: Eur J Vasc Endovasc Surg Source Type: research