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Total 173 results found since Jan 2013.

Comparative outcomes associated with rivaroxaban versus warfarin use in elderly patients with atrial fibrillation or acute venous thromboembolism managed in the United States: a systematic review of observational studies
CONCLUSIONS: This systematic review supports findings from subgroup analyses of randomized controlled trials that, compared with warfarin, rivaroxaban is associated with generally neutral or positive effects on thrombosis and a mixed picture on bleeding outcomes in older adults with either NVAF or VTE treated in the United States.PMID:37584187 | DOI:10.1080/03007995.2023.2247988
Source: Current Medical Research and Opinion - August 16, 2023 Category: Research Authors: William L Baker Matthew S Roberts Youssef Bessada Kimberly S Caroti Veronica Ashton Brahim K Bookhart Craig I Coleman Source Type: research

The Price of Keeping the Rhythm: Increased Bleeding Risk in Patients with Atrial Fibrillation Concurrently Prescribed Amiodarone and Factor Xa Inhibitors
Atrial fibrillation is the most common sustained cardiac arrhythmia affecting nearly 2% of the population of the United States.1 Patients with atrial fibrillation are twice as likely to have a myocardial infarction and five-times as likely to have a stroke.1 Current guidelines recommend antiarrhythmic pharmacotherapy in patients with symptomatic atrial fibrillation as first-line management.2-4 Amiodarone is a very effective, and therefore, a commonly prescribed agent for this purpose.5 Anticoagulation is a key tenet in the management of atrial fibrillation due to the increased tendency of left atrial appendage clot formati...
Source: Journal of Cardiothoracic and Vascular Anesthesia - August 10, 2023 Category: Anesthesiology Authors: Nicolas Kumar, Manoj H. Iyer, Adam Dalia, Amit Bardia Tags: Editorial Source Type: research

Will unpredictable side effects dim the promise of new Alzheimer ’s drugs?
A sea change is underway in the treatment of Alzheimer’s disease, where for the first time a drug that targets the disease’s pathology and clearly slows cognitive decline has hit the U.S. market. A related therapy will likely be approved in the coming months. As many neurologists, patients, and brain scientists celebrate, they’re also nervously eyeing complications from treatment: brain swelling and bleeding, which in clinical trials affected up to about one-third of patients and ranged from asymptomatic to fatal. The side effect—amyloid-related imaging abnormalities, or ARIA—remains mysterious. “We don’...
Source: Science of Aging Knowledge Environment - August 2, 2023 Category: Geriatrics Source Type: research

For healthy older people, aspirin could cause more bleeding.
A new analysis of older people who have never had a heart attack or stroke suggests limited protective power of daily low-dose aspirin, and worrisome side effects.
Source: NYT Health - July 26, 2023 Category: Consumer Health News Authors: Emily Baumgaertner Tags: your-feed-science Heart Aspirin Elderly Research Falls Clinical Trials Stroke Drugs (Pharmaceuticals) Preventive Medicine Brain Age, Chronological JAMA (Journal of American Medical Assn) United States Preventive Services Task For Source Type: news

Poststroke venous thromboembolism and neutrophil activation: an illustrated review
Res Pract Thromb Haemost. 2023 Apr 29;7(4):100170. doi: 10.1016/j.rpth.2023.100170. eCollection 2023 May.ABSTRACTPatients with acute ischemic stroke are at a high risk of venous thromboembolism (VTE), such as deep vein thrombosis (DVT), estimated to affect approximately 80,000 patients with stroke each year in the United States. The prevalence of symptomatic DVT after acute stroke is approximately 10%. VTE is associated with increased rates of in-hospital death and disability, with higher prevalence of in-hospital complications and increased 1-year mortality in patients with stroke. Current guidelines recommend the use of ...
Source: Thrombosis and Haemostasis - June 5, 2023 Category: Hematology Authors: Nirav Dhanesha Junaid Ansari Nilesh Pandey Harpreet Kaur Chiranjiv Virk Karen Y Stokes Source Type: research

What Sub-Saharan African Nations Can Teach the U.S. About Black Maternal Health
While poor maternal outcomes among Black women in the U.S. is not new, improving it is imperative. U.S. policymakers can look to sub-Saharan Africa for guidance on reversing this trend. Credit: Ernest Ankomah/IPSBy Ifeanyi NsoforABUJA, Jun 2 2023 (IPS) New research shows that Black mothers in the United States disproportionately live in counties with higher maternal vulnerability and face greater risk of preterm death for the fetus, greater risk of low birth weight for a baby, and a higher number of maternal deaths. While poor maternal outcomes among Black women in the U.S. is not new, improving it is imperative. U.S. poli...
Source: IPS Inter Press Service - Health - June 2, 2023 Category: International Medicine & Public Health Authors: Ifeanyi Nsofor Tags: Africa Gender Headlines Health Inequality North America Poverty & SDGs Maternal Health Source Type: news

Empowering stroke survivors: understanding the role of multidisciplinary rehabilitation Impact of stroke
Stroke is one of the leading causes of disability worldwide, with someone having a stroke every 40 seconds in the United-States[1]. A stroke can occur by clot that interrupts blood flow in the brain. It can also be caused by a burst of a blood vessel that causes bleeding in the brain. There are also other unknown causes of stroke which occur less frequently. A stroke causes brain cells to die as they no longer receive oxygen and nutrients from the blood. Some of the most common risk factors of stroke are high blood pressure, high cholesterol, heart diseases, diabetes, smoking, physical inactivity, and obesity[2].
Source: Archives of Physical Medicine and Rehabilitation - April 24, 2023 Category: Rehabilitation Authors: Urvashy Gopaul, Demers Marika, Marina Charalambous, William R Reed Source Type: research

Empowering Stroke Survivors: Understanding The Role of Multidisciplinary Rehabilitation
Stroke is 1 of the leading causes of disability worldwide, with someone having a stroke every 40 seconds in the United-States.1 A stroke can occur by clot that interrupts blood flow in the brain. It can also be caused by a burst of a blood vessel that causes bleeding in the brain. There are also other unknown causes of stroke which occur less frequently. A stroke causes brain cells to die as they no longer receive oxygen and nutrients from the blood. Some of the most common risk factors of stroke are high blood pressure, high cholesterol, heart diseases, diabetes, smoking, physical inactivity, and obesity.
Source: Archives of Physical Medicine and Rehabilitation - April 24, 2023 Category: Rehabilitation Tags: INFORMATION/EDUCATION PAGE Source Type: research

Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines
AbstractPurpose of ReviewStroke is a leading cause of death and disability worldwide. The annual incidence of new or recurrent stroke is approximately 795,000 cases per year in the United States, of which 87% are ischemic in nature. In addition to the management of modifiable high-risk factors to reduce the risk of recurrent stroke, antithrombotic agents (antiplatelets and anticoagulants) play an important role in secondary stroke prevention. This review will discuss the published literature on the use of antiplatelets and anticoagulants in secondary prevention of acute ischemic stroke and transient ischemic attack (TIA), ...
Source: Current Neurology and Neuroscience Reports - April 11, 2023 Category: Neuroscience Source Type: research

Sixth Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report
CONCLUSIONS: This Sixth Pedimacs Report demonstrates the continued evolution of the pediatric field. The complexity of cardiac physiologies and anatomical constraint mandates the need for multiple types of devices utilized (PC, PP, IC). Detailed analyses of each device type in this report provide valuable information to further advance the care of this challenging and vulnerable population.PMID:36402175 | DOI:10.1016/j.athoracsur.2022.10.042
Source: The Annals of Thoracic Surgery - November 19, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Iki Adachi David M Peng Seth A Hollander Kathleen E Simpson Ryan R Davies Jeffrey P Jacobs Christina J VanderPluym Francis Fynn-Thompson Dennis A Wells Sabrina P Law Shahnawaz Amdani Ryan Cantor Devin Koehl James K Kirklin David L S Morales Joseph W Rossa Source Type: research

Readmission in patients undergoing percutaneous patent foramen ovale closure in the United States
Current estimates suggest that a patent foramen ovale (PFO) may exist in up to 25% of the general population and is a potential risk factor for embolic, ischemic stroke. PFO closure complications include bleeding, need for procedure-related surgical intervention, pulmonary emboli, device malpositioning, new onset atrial arrhythmias, and transient atrioventricular block. Rates of PFO closure complications at a national level in the Unites States remain unknown. To address this, we performed a contemporary nationwide study using the 2016 and 2017 Nationwide Readmissions Database (NRD) to identify patterns of readmissions aft...
Source: International Journal of Cardiology - November 7, 2022 Category: Cardiology Authors: Chayakrit Krittanawong, Bing Yue, Muzamil Khawaja, Anirudh Kumar, Hafeez Ul Hassan Virk, Zhen Wang, Sana Hanif, Umair Khalid, Ali E. Denktas, Clifford J. Kavinsky, John J. Volpi, Hani Jneid Source Type: research