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Total 773 results found since Jan 2013.

ICAM-1 and VCAM-1: gatekeepers in various inflammatory and cardiovascular disorders
Clin Chim Acta. 2023 Jul 11:117487. doi: 10.1016/j.cca.2023.117487. Online ahead of print.ABSTRACTLeukocyte migration from the vascular compartment is critical fornormal lymphocyte recirculation in specific tissues and immune response in inflammatory locations. Leukocyte recruitment, migration to inflammatory areas, and targeting in the extravascular space are caused by cellular stimulation and local expression of adhesion molecules. Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) belong to the immunoglobulin superfamily of cell adhesion molecules with a crucial role in mediating t...
Source: International Journal of Clinical Chemistry - July 13, 2023 Category: Chemistry Authors: Varinder Singh Rupinder Kaur Pratima Kumari Chirag Pasricha Ravinder Singh Source Type: research

Characterising heart rhythm abnormalities associated with Xp22.31 deletion
Conclusion Our data suggest AHRs are frequently associated with Xp22.31 deletion, and highlight subgroups of deletion carriers that may be prioritised for screening. Examining cardiac function further in deletion carriers, and in model systems lacking steroid sulfatase, may clarify AF pathophysiology.
Source: Journal of Medical Genetics - June 21, 2023 Category: Genetics & Stem Cells Authors: Wren, G., Baker, E., Underwood, J., Humby, T., Thompson, A., Kirov, G., Escott-Price, V., Davies, W. Tags: Open access Genotype-phenotype correlations Source Type: research

Estimate of the prevalence of subjects with chronic diseases in a province of Northern Italy: a retrospective study based on administrative databases
Conclusions Despite the difficulty of having a unique definition of chronic disease, the prevalence obtained was coherent with the estimates reported by other national surveillance systems such as Passi and Passi d’Argento. Underestimates were observed when international comparisons were done; however, when we used less stringent definitions of chronic diseases, similar results were obtained.
Source: BMJ Open - June 19, 2023 Category: General Medicine Authors: Airoldi, C., Pagnoni, F., Cena, T., Ceriotti, D., De Ambrosi, D., De Vito, M., Faggiano, F. Tags: Open access, Public health Source Type: research

Can ‘toxic’ bilirubin treat a variety of illnesses?
Generations of medical and biology students have been instilled with a dim view of bilirubin. Spawned when the body trashes old red blood cells, the molecule is harmful refuse and a sign of illness. High blood levels cause jaundice, which turns the eyes and skin yellow and can signal liver trouble. Newborns can’t process the compound, and although high levels normally subside, a persistent surplus can cause brain damage. Yet later this year up to 40 healthy Australian volunteers may begin receiving infusions of the supposedly good-for-nothing molecule. They will be participating in a phase 1 safety trial, sponsored ...
Source: ScienceNOW - June 8, 2023 Category: Science Source Type: news

Trends in the Prevalence of Chronic Non-Communicable Diseases and Multimorbidity across Socioeconomic Gradients in Rural Southwest China
ConclusionsThe prevalence of NCDs multimorbidity increased substantially across all socioeconomic gradients in rural southwest China. Future interventions to further manage NCDs and their multimorbidity must be tailored to address socioeconomic factors.
Source: The Journal of Nutrition, Health and Aging - June 5, 2023 Category: Nutrition Source Type: research

Combining Mendelian randomization and network deconvolution for inference of causal networks with GWAS summary data
by Zhaotong Lin, Haoran Xue, Wei Pan Mendelian randomization (MR) has been increasingly applied for causal inference with observational data by using genetic variants as instrumental variables (IVs). However, the current practice of MR has been largely restricted to investigating thetotal causal effect between two traits, while it would be useful to infer thedirect causal effect between any two of many traits (by accounting for indirect or mediating effects through other traits). For this purpose we propose a two-step approach: we first apply an extended MR method to infer (i.e. both estimate and test) a causal network of...
Source: PLoS Genetics - May 18, 2023 Category: Genetics & Stem Cells Authors: Zhaotong Lin Source Type: research

Stress as a possible cause of a high incidence of hypertension and diabetes and a low incidence of asthma in the Iraqi population
This study also reveals that a considerable number of people were unaware of their hypertension and diabetes. Exposure to daily life stress among Iraqi people may play a role in the observed incidence of these morbidities.PMID:37168309 | PMC:PMC10165509 | DOI:10.25122/jml-2022-0266
Source: Journal of Medicine and Life - May 11, 2023 Category: General Medicine Authors: Zahraa Al-Isawi Salim Kadhim Yahya Yahya Najah Rayish Hadi Source Type: research