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Diagnosis of Obstructive Sleep Apnea in Patients with Associated Comorbidity
Adv Exp Med Biol. 2022;1384:43-61. doi: 10.1007/978-3-031-06413-5_4.ABSTRACTObstructive sleep apnea (OSA) is a heterogeneous disease with many physiological implications. OSA is associated with a great diversity of diseases, with which it shares common and very often bidirectional pathophysiological mechanisms, leading to significantly negative implications on morbidity and mortality. In these patients, underdiagnosis of OSA is high. Concerning cardiorespiratory comorbidities, several studies have assessed the usefulness of simplified screening tests for OSA in patients with hypertension, COPD, heart failure, atrial fibril...
Source: Advances in Experimental Medicine and Biology - October 10, 2022 Category: Research Authors: F élix Del Campo C Ainhoa Arroyo Carlos Zamarr ón Daniel Álvarez Source Type: research

Development of a digital medicine solution for home-based obstructive sleep apnea phenotyping
Conclusion: AI-based home sleep testing of MM combined to on-line questionnaire provides easy patient assignment to relevant clinical phenotype and dedicated care.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Martinot, J.-B., Bailly, S., Hostaux, L., Tamisier, R., Le-Dong, N.-N., Pepin, J. Tags: Sleep and control of breathing Source Type: research

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt
Conclusion We have shown that SCD subjects are much more likely than non-SCD subjects to have impaired cardiac, but intact peripheral responses to orthostatic stress induced by HUT. These abnormal responses are associated with low baseline cardiac parasympathetic activity, independent of hemoglobin level. The classification of autonomic phenotypes based on HUT response may have potential use for predicting disease severity, guiding and targeting treatments/interventions to alleviate the risk of adverse outcomes in SCD. Ethics Statement All experiments were conducted at Children’s Hospital Los Angeles (CHLA). The ...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

Will Too Much Sleep Make You Fat?
In last week's article, you learned exactly how not getting enough sleep (less than about 7 hours per night), can cause fat gain, muscle loss and an inability to control the appetite, along with increased risk for a host of chronic diseases such as diabetes and obesity. But the solution is definitely not to begin sleeping as much as you possibly can. Oversleeping may seem like a good idea to fight off the fat gain that can accompany undersleeping, but it's been shown that sleeping in excess of 9 hours per night can be just as damaging to your sleep cycles and your waistline as not getting enough sleep, and in this article...
Source: Healthy Living - The Huffington Post - August 5, 2016 Category: Consumer Health News Source Type: news