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Real-world impact of disease on functioning and activity: what is missed when using general instruments to estimate quality-adjusted life year
CONCLUSION: Differences in rankings of disease severity by metric indicate that the results of cost-utility analyses might be biased against treatments for certain diseases. As patient preferences for clinical outcomes vary, the full burden of disease should be considered in evaluations. Restricting access to treatments based on an incomplete estimate of burden could lead to misallocation of resources and a withholding of therapies that patients find valuable.PMID:34775901 | DOI:10.1080/03007995.2021.2006535
Source: Current Medical Research and Opinion - November 15, 2021 Category: Research Authors: Tingjian Yan Jesse D Ortendahl Eunice Chang Zac Wessler Amanda L Harmon Michael S Broder Source Type: research

Cancers, Vol. 13, Pages 3368: Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007 –2018
Cancers, Vol. 13, Pages 3368: Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007–2018 Cancers doi: 10.3390/cancers13133368 Authors: Dafina Petrova Andrés Catena Miguel Rodríguez-Barranco Daniel Redondo-Sánchez Eloísa Bayo-Lozano Rocio Garcia-Retamero José-Juan Jiménez-Moleón María-José Sánchez Many adult cancer patients present one or more physical comorbidities. Besides interfering with treatment and prognosis, physical comorbidities could also increase the already heightened psychological risk of cancer patients. To test this possibility, we...
Source: Cancers - July 5, 2021 Category: Cancer & Oncology Authors: Dafina Petrova Andr és Catena Miguel Rodr íguez-Barranco Daniel Redondo-S ánchez Elo ísa Bayo-Lozano Rocio Garcia-Retamero Jos é-Juan Jiménez-Moleón Mar ía-José Sánchez Tags: Article Source Type: research

Prevalence of Activity Limitations and Association with Multimorbidity Among US Adults 50 to 64  Years Old
ConclusionsProblems with function are not limited to older adults and multimorbidity may be helpful for identifying middle-aged adults with a high prevalence of activity limitations.
Source: Journal of General Internal Medicine - August 20, 2019 Category: Internal Medicine Source Type: research

New Biomarkers for Atherothrombosis in Antiphospholipid Syndrome: Genomics and Epigenetics Approaches
Conclusions In recent years, there have been many advances in the understanding of the molecular basis for vascular involvement in APS, but many areas need to be further investigated, in particular the association between altered genetic/epigenetic profiles, autoantibodies and clinical manifestations, and the effectiveness of new therapeutic strategies. It would be interesting to apply next generation sequencing technologies like RNA-Seq along with GWAS to screen both, the gene profile and the whole transcriptome of large cohorts of primary APS patients, in order to reveal the mutations/polymorphisms, post-transcriptiona...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Obesity Prevention Resources for Special Populations
From the NLM Outreach and Special Populations Branch: Obesity is a major health issue in the United States, and the Centers for Disease Control and Prevention (CDC) offer some alarming facts about obesity in both adults and children in the US: Obesity affects about 1 in 6 children in the US. More than 1/3 of US adults are obese. The highest age-adjusted rates of obesity impact African Americans (48.1%) followed by Hispanic Americans (42.5%). Obesity can put an individual at increased risk for diabetes, heart disease, stroke, arthritis, and some cancers. Changes in nutrition and exercise habits can help to prevent obes...
Source: NN/LM Middle Atlantic Region Blog - July 5, 2017 Category: Databases & Libraries Authors: Hannah Sinemus Tags: Consumer Health Education Public Health Source Type: news