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Cancers, Vol. 15, Pages 3409: Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment
Conclusions: Participants with cancer and CI are open to research procedures and interventions that are traditionally less utilized, which may facilitate the discovery of the pathogenesis and interventions for cancer-related cognitive impairment (CRCI).
Source: Cancers - June 29, 2023 Category: Cancer & Oncology Authors: Ding Quan Ng Daniella Chan Munjal M. Acharya Joshua D. Grill Alexandre Chan Tags: Article Source Type: research

Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers
AbstractBlood pressure variability is an emerging risk factor for dementia but relationships with markers of neurodegeneration and Alzheimer ’s disease risk are understudied. We investigated blood pressure variability over one year and follow-up medial temporal brain volume change in apolipoprotein ϵ4 carriers and non-carriers, and in those with and without Alzheimer’s disease biomarker abnormality. 1051 Alzheimer’s Disease Neuroi maging Initiative participants without history of dementia or stroke underwent 3–4 blood pressure measurements over 12 months and ≥ 1 MRI thereafter. A subset (n = 252) underw...
Source: Brain Imaging and Behavior - September 28, 2021 Category: Neurology Source Type: research

Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data
Conclusion: The PVLT appears sensitive to markers of neurodegeneration, including temporal regions affected by AD. Conversely, in cognitively normal older adults, PVLT performance seems to relate to white matter disease and axonal injury, perhaps reflecting non-AD pathways to cognitive change. Enhanced normative data enrich the clinical utility of this tool.Dement Geriatr Cogn Disord Extra 2018;8:476 –491
Source: Dementia and Geriatric Cognitive Disorders Extra - December 6, 2018 Category: Geriatrics Source Type: research

Brain metabolic correlates of CSF Tau protein in a large cohort of Alzheimer's disease patients: a CSF and FDG PET study.
CONCLUSIONS: t-Tau deposition in brain is related to temporal, parietal and frontal hypometabolism in AD. PMID: 29066367 [PubMed - as supplied by publisher]
Source: Brain Research - October 21, 2017 Category: Neurology Authors: Chiaravalloti A, Barbagallo G, Ricci M, Martorana A, Ursini F, Sannino P, Karalis G, Schillaci O Tags: Brain Res Source Type: research

Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults
Conclusions: PP elevation is associated with increased CSF P-tau and decreased Aβ1–42 in cognitively normal older adults, suggesting that pulsatile hemodynamics may be related to amyloidosis and tau-related neurodegeneration. The relationship between PP and CSF biomarkers is age-dependent and observed only in participants in the fifth and sixth decades of life.
Source: Neurology - December 2, 2013 Category: Neurology Authors: Nation, D. A., Edland, S. D., Bondi, M. W., Salmon, D. P., Delano-Wood, L., Peskind, E. R., Quinn, J. F., Galasko, D. R. Tags: Alzheimer's disease ARTICLE Source Type: research

Effects of Intravenous Solanezumab 400 mg q 4 Weeks vs. Placebo on Biomarkers in Patients with Mild to Moderate Alzheimer's Disease: Results of Two Phase 3 Studies (P01.011)
CONCLUSIONS: Solanezumab target engagement is associated with alteration of amyloid biology. There was a lack of apparent effect on markers of neurodegeneration. The overall findings lend support for the amyloid cascade hypothesis and suggest that various aspects of the cascade are viable targets for treatment of Alzheimer's disease.Supported by: Eli Lilly and Co.Disclosure: Dr. Hake has received personal compensation for activities with Eli Lilly and Company as an employee. Dr. Hake holds stock in Eli Lilly and Company. Dr. Siemers has received personal compensation for activities with Eli Lilly and Company as an employee...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hake, A., Siemers, E., Carlson, C., Estergard, W., Sundell, K., Henley, D., Eads, J., Sexton, C., Liu-Seifert, H., Sethuraman, G., Chen, Y.-F., Mintun, M., Pontecorvo, M., Joshi, A., Dean, R., Willis, B., Demattos, R., Mohs, R. Tags: P01 Aging and Dementia: Therapeutics and Clinical Trials Source Type: research