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Long non-coding RNA HOXA11-AS regulates ischemic neuronal death by targeting miR-337-3p/YBX1 signaling pathway: protective effect of dexmedetomidine
This study aimed to explore the possible link between Dex and HOXA11-AS in protecting neuronal cells from by ischemia/reperfusion-induced apoptosis. We used oxygen-glucose deprivation and reoxygenation (OGD/R) in mouse neuroblastoma Neuro-2a cells and middle cerebral artery occlusion (MACO) mouse model to test the link. We found that Dex significantly alleviated OGD/R-induced DNA fragmentation, cell viability and apoptosis, and rescued the decreased HOXA11-AS expression after ischemic damage in Neuro-2a cells. Gain-/loss-of-function studies revealed that HOXA11-AS promoted proliferation, inhibited apoptosis in Neuro-2a cel...
Source: Aging - April 14, 2023 Category: Biomedical Science Authors: Fei Yan Pinxiao Wang Xiaojian Yang Fuli Wang Source Type: research

Neuroinductive properties of mGDNF depend on the producer, < i > E < /i > . < i > Coli < /i > or human cells
by Dzhirgala V. Shamadykova, Dmitry Y. Panteleev, Nadezhda N. Kust, Ekaterina A. Savchenko, Ekaterina Y. Rybalkina, Alexander V. Revishchin, Galina V. Pavlova The glial cell line‐derived neurotrophic factor (GDNF) is involved in the survival of dopaminergic neurons. Besides, GDNF can also induce axonal growth and creation of new functional synapses. GDNF potential is promising for translation to treat diseases associated with neuronal death: neurodege nerative disorders, ischemic stroke, and cerebral or spinal cord damages. Unproductive clinical trials of GDNF for Parkinson’s disease treatment have induced to study th...
Source: PLoS One - October 11, 2021 Category: Biomedical Science Authors: Dzhirgala V. Shamadykova Source Type: research

Effects of uric acid on oxidative and nitrosative stress and other related parameters in SH-SY5Y human neuroblastoma cells.
Uric acid (UA) is the end -product of purine catabolism in humans and higher primates and comprises about 65% of the total antioxidant capacity of plasma [1]. Urate circulates in humans at concentrations that are near its limit of solubility and many times higher than those in most other mammals. In patients with ischemic stroke, the most common type of stroke which is a leading cause of disability and the second most common cause of dementia, UA reduces the incidence of early clinical deterioration and improves outcomes compared to placebo [2].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 30, 2020 Category: Biomedical Science Authors: Frederic M ármol, Juan Sanchez, Albert Martínez-Pinteño Source Type: research