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Repurposing of Clinically Approved Poly-(ADP-Ribose) Polymerase Inhibitors for the Therapy of Sepsis
Sepsis’ pathogenesis involves multiple mechanisms that lead to a dysregulation of the host's response. Significant efforts have been made in search of interventions that can reverse this situation and increase patient survival. Poly (ADP-polymerase) (PARP) is a constitutive nuclear and mitochondrial enzyme, which functions as a co-activator and co-repressor of gene transcription, thus regulating the production of inflammatory mediators. Several studies have already demonstrated an overactivation of PARP1 in various human pathophysiological conditions and that its inhibition has benefits in regulating intracellular proces...
Source: Shock - November 26, 2021 Category: Emergency Medicine Tags: Review Articles Source Type: research

Therapeutic oxygen delivery by perfluorocarbon-based colloids
Adv Colloid Interface Sci. 2021 May 1;294:102407. doi: 10.1016/j.cis.2021.102407. Online ahead of print.ABSTRACTAfter the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed untoward effects to the product, the development of perfluorocarbon (PFC)-based O2 nanoemulsions ("blood substitutes") has come to a low. Yet, significant further demonstrations of PFC O2-delivery efficacy have continuously been reported, such as relief of hypoxia after myocardial infarction or stroke; protection of vital organs during surg...
Source: Advances in Colloid and Interface Science - June 13, 2021 Category: Chemistry Authors: Marie Pierre Krafft Jean G Riess Source Type: research

Ferroptosis and its potential as a therapeutic target
Biochem Pharmacol. 2021 Feb 22:114486. doi: 10.1016/j.bcp.2021.114486. Online ahead of print.ABSTRACTFerroptosis is a recently defined form of programmed cell death that is different from apoptosis. It is an iron-dependent programmed cell death and the accumulation of lipid hydroperoxides to lethal levels make ferroptosis distinct. Ferroptosis can be effectively regulated by a number of cellular variables including iron content, amino acid uptake, polyunsaturated fatty acid incorporation, glutathione biosynthesis, and NADPH levels. A number of severe and common degenerative diseases in humans such as Parkinson's disease an...
Source: Biochemical Pharmacology - February 25, 2021 Category: Drugs & Pharmacology Authors: Hanshu Yuan Justin Pratte Charles Giardina Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Isotropic Generalized Diffusion Tensor MRI
Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring and mapping features of the bulk or average apparent diffusion coefficient (ADC) of water in tissue – aiding in stroke diagnosis and cancer therapy assessment. The pulse sequences and software enable MRI scanners to yield diffusion weighted images (DWI) that are orientationally ...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Publication date: 5 October 2017 Source:Cell, Volume 171, Issue 2 Author(s): Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I. Bush, Marcus Conrad, Scott J. Dixon, Simone Fulda, Sergio Gascón, Stavroula K. Hatzios, Valerian E. Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E. Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C. Pagnussat, Jason Park, Qitao Ran, Craig S. Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M. Torti, Suzy V. Torti, Shinya Toyokuni, K.A. Woerpel, Donna D. Zhang Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation...
Source: Cell - October 29, 2017 Category: Cytology Source Type: research

Thalidomide Analogs that Inhibit Inflammation and Angiogenesis
Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several inflammatory disorders. However, thalidomide is known for its teratogenic adverse effects when first clinically introduced in the 1950s, and is associated with drowsiness and peripheral neuropathy. Hence, there is intense interest to synthesize, identify and develop safer analogs.Researchers at the National Institute on Aging’s Drug Design and Development Section synthesized novel thalidomide analogs that demonstrate clinical potent...
Source: NIH OTT Licensing Opportunities - December 23, 2015 Category: Research Authors: admin Source Type: research

Healing through music
The last time I had a mammogram, I got a big surprise — and it was a good one. A string quartet was playing just outside the doors of the breast imaging center, and my thoughts immediately shifted from “What are they going to find on the mammogram?” to “Is that Schubert, or Beethoven?” By the time my name was called, I had almost forgotten why I was there. The unexpected concert was the work of Holly Chartrand and Lorrie Kubicek, music therapists and co-coordinators of the Environmental Music Program at Massachusetts General Hospital. But bringing music to hospital corridors is just a sideline for music therapist...
Source: New Harvard Health Information - November 5, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Behavioral Health Mental Health Pain Management Surgery Source Type: news

The Most Promising Cancer-Fighter In Years
For a while now, I’ve been recommending a powerful antioxidant with the unpronounceable name, pyrroloquinoline quinine – or PQQ for short. And although I recommend this compound to almost everyone who comes to see me at my wellness clinic in South Florida because of its energy-giving qualities, I’ve also observed its extraordinary power to fight cancer. For years, I’ve seen PQQ work wonders with my older patients, because it keeps you feeling young by giving your cells extra energy. PQQ was first discovered back in 1979 by a team of Japanese scientists, who knew little about the substance, except that i...
Source: Al Sears, MD Natural Remedies - March 24, 2015 Category: Complementary Medicine Authors: Andrew Britton Tags: Anti-Aging antioxidants Cancer energy Source Type: news

Green tea compound may improve cancer drugs
Conclusion This study developed a new way of packaging and carrying protein drugs by combining them with a green tea extract called Epigallocatechin-3-O-gallate (EGCG), which itself may have anti-cancer properties. They formed a complex between derivatives of EGCG and the protein cancer drug Herceptin. Tests in the laboratory and in mice indicated it might have better anti-cancer properties than non-complexed free Herceptin. This is encouraging research and may lead to improvements in delivery mechanisms for protein drugs further down the line. But this research remains at a very early stage of development. The results f...
Source: NHS News Feed - October 6, 2014 Category: Consumer Health News Tags: Cancer Medication Source Type: news

Could Antibodies or Hormones Slow Brain Damage from Alzheimer’s?
Scientists have discovered that certain antibodies may help slow the progression of Alzheimer’s disease. Dr. Patricia Salinas of University College London, UK, and her team focused on a protein called Dkk1, present in raised levels in the brains of people with Alzheimer’s disease. Using brain samples from mice, the team looked at the progressive disintegration of synapses in the hippocampus when exposed to a protein called amyloid-beta, thought to be central to the development of Alzheimer’s disease. “Synaptic loss mediated by amyloid-beta in early stages of the disease might contribute to cognitive...
Source: Psych Central - June 1, 2013 Category: Psychiatry Authors: Jane Collingwood Tags: Aging Alzheimer's Disorders General Seniors Abnormal Deposits Alzheimer S Disease Antibodies Brain Area Brain Damage Cognitive Decline Cognitive Impairments Disintegration Dr Patricia Dr Simon Hippocampus Journal Of Neurosc Source Type: news