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Total 35 results found since Jan 2013.
Can ‘toxic’ bilirubin treat a variety of illnesses?
Generations of medical and biology students have been instilled with a dim view of bilirubin. Spawned when the body trashes old red blood cells, the molecule is harmful refuse and a sign of illness. High blood levels cause jaundice, which turns the eyes and skin yellow and can signal liver trouble. Newborns can’t process the compound, and although high levels normally subside, a persistent surplus can cause brain damage.
Yet later this year up to 40 healthy Australian volunteers may begin receiving infusions of the supposedly good-for-nothing molecule. They will be participating in a phase 1 safety trial, sponsored ...
Source: ScienceNOW - June 8, 2023 Category: Science Source Type: news
A measurement for chronic pain is a scientific holy grail – and we’re getting closer | Abdul-Ghaaliq Lalkhen
People who have chronic pain without a visible injury are often not believed, but new research can help visualise that painMost people, including doctors, do not appreciate that the organ that produces pain is the brain. A broken bone, damaged tissue or a bleeding wound is often the focus, but the experience of pain is the sum total of more than just the physical injury – it is the result of information sent from our nerves being filtered through an individual’s unique psychological makeup, genetics, gender, beliefs, expectations, motivations and emotional context. Pain is therefore an individual experience, and often ...
Source: Guardian Unlimited Science - May 25, 2023 Category: Science Authors: Abdul-Ghaaliq Lalkhen Tags: Medical research Health Science Neuroscience UK news Stroke Cancer Back pain Diabetes Source Type: news
The final puff: Can New Zealand quit smoking for good?
Smoking kills. Ayesha Verrall has seen it up close. As a young resident physician in New Zealand’s public hospitals in the 2000s, Verrall watched smokers come into the emergency ward every night, struggling to breathe with their damaged lungs. Later, as an infectious disease specialist, she saw how smoking exacerbated illness in individuals diagnosed with tuberculosis and HIV/AIDS. She would tell them: “The best thing you can do to promote your health, other than take the pills, is to quit smoking.”
Verrall is still urging citizens to give up cigarettes—no longer just one by one, but by the thousands. As New...
Source: ScienceNOW - December 9, 2022 Category: Science Source Type: news
Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations Biophysics and Computational Biology
The voltage-gated Hv1 proton channel is a ubiquitous membrane protein that has roles in a variety of cellular processes, including proton extrusion, pH regulation, production of reactive oxygen species, proliferation of cancer cells, and increased brain damage during ischemic stroke. A crystal structure of an Hv1 construct in a putative...
Source: Proceedings of the National Academy of Sciences - June 15, 2020 Category: Science Authors: Andrew D. Geragotelis, Mona L. Wood, Hendrik Goddeke, Liang Hong, Parker D. Webster, Eric K. Wong, J. Alfredo Freites, Francesco Tombola, Douglas J. Tobias Tags: Biological Sciences Source Type: research
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier Chemistry
Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury remains an elusive goal. Using a mouse model of acute brain inflammation induced by local tumor necrosis factor alpha (TNFα), we found that uptake of intravenously injected antibody to vascular cell adhesion molecule 1 (anti-VCAM) in the...
Source: Proceedings of the National Academy of Sciences - February 17, 2020 Category: Science Authors: Oscar A. Marcos-Contreras, Colin F. Greineder, Raisa Yu Kiseleva, Hamideh Parhiz, Landis R. Walsh, Viviana Zuluaga-Ramirez, Jacob W. Myerson, Elizabeth D. Hood, Carlos H. Villa, Istvan Tombacz, Norbert Pardi, Alecia Seliga, Barbara L. Mui, Ying K. Tam, Pa Tags: Physical Sciences Source Type: research
How to Keep Alzheimer ’s From Bringing About the Zombie Apocalypse
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer.
My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true.
Seven years ...
Source: TIME: Science - November 20, 2019 Category: Science Authors: Jay Newton-Small Tags: Uncategorized Alzheimer's Disease Source Type: news
The Director of the NIH Lays Out His Vision of the Future of Medical Science
Our world has never witnessed a time of greater promise for improving human health. Many of today’s health advances have stemmed from a long arc of discovery that begins with strong, steady support for basic science. In large part because of fundamental research funded by the National Institutes of Health (NIH), which traces its roots to 1887, Americans are living longer, healthier lives. Life expectancy for a baby born in the U.S. has risen from 47 years in 1900 to more than 78 years today. Among the advances that have helped to make this possible are a 70% decline in the U.S. death rate from cardiovascular disease ...
Source: TIME: Science - October 24, 2019 Category: Science Authors: Dr. Francis S. Collins Tags: Uncategorized Healthcare medicine Source Type: news
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
Severe local acidosis causes tissue damage and pain, and is one of the hallmarks of many diseases including ischemia, cancer, and inflammation. However, the molecular mechanisms of the cellular response to acid are not fully understood. We performed an unbiased RNA interference screen and identified PAC (TMEM206) as being essential for the widely observed proton-activated Cl– (PAC) currents (ICl,H). Overexpression of human PAC in PAC knockout cells generated ICl,H with the same characteristics as the endogenous ones. Zebrafish PAC encodes a PAC channel with distinct properties. Knockout of mouse Pac abolished ICl,H i...
Source: ScienceNOW - April 24, 2019 Category: Science Authors: Yang, J., Chen, J., del Carmen Vitery, M., Osei-Owusu, J., Chu, J., Yu, H., Sun, S., Qiu, Z. Tags: Cell Biology reports Source Type: news
Lowering Your Blood Pressure Could Reduce Alzheimer ’s Risk, New Research Shows
Margaret Daffodil Graham tries to live a healthy life, particularly since she has a health issue that requires constant attention. Like more than 100 million other Americans, the 74-year-old from Winston-Salem, N.C., has high blood pressure, and she has been taking medication to control it since she was in her 30s. So when she read that her nearby hospital, Wake Forest Baptist Medical Center, was looking for people with hypertension to volunteer for a study, she quickly signed up, knowing the doctors would monitor her blood pressure more intensively and hopefully lower her risk of developing heart disease and stroke.
What...
Source: TIME: Science - August 9, 2018 Category: Science Authors: Alice Park Tags: Uncategorized Aging Alzheimer's Research Source Type: news
In search of the stroke detector
Up to 50% of stroke diagnoses are inaccurate. What if a small biosensor could do the job precisely? Robert McCrum, who survived a ‘brain attack’ 22 years ago, traces one team’s long journey to a breakthroughStroke, or “brain attack”, is the third biggest killer in the western world, after cancer and heart failure. The life-changing effects associated with this simple, Anglo-Saxon word are readily explained: a stroke occurs when the blood supply to the brain is disrupted by a blood vessel either bursting or blocking, so that the part of the brain supplied by this blood vessel dies.The brain is a much more com...
Source: Guardian Unlimited Science - January 22, 2017 Category: Science Authors: Robert McCrum Tags: Medical research Health NHS Biochemistry and molecular biology Neuroscience Society Source Type: news
Reflections on the Future of Medicine
Recently, I traveled through China. I climbed mountains, hiked through forests, crossed deep valleys. I visited cities of every size. I floated across lakes and traveled beautiful shorelines churning with life. As a man of a certain age, I began to compare the permanence of the timeless landscape with the evanescence of my own existence. Yet, as a scientist, I knew these reflections were flawed.
Scientists are trained to think in terms of aeons, millenia, and lifetimes. Consider the paradox. Is it the solid mountain or fragile the forest that is permanent? Is it the massive shoreline cliffs or the teeming shore life that...
Source: Science - The Huffington Post - January 9, 2017 Category: Science Source Type: news
Innovative technique to examine blood vessels in 3D help unlock secrets of the brain
An important breakthrough has been made in the examination of blood vessels in the brain giving scientists a clearer understanding of how dementia, brain cancer and stroke can affect veins and capillaries in this organ.
Source: ScienceDaily Headlines - January 5, 2017 Category: Science Source Type: news
Modulatory effect of cilostazol on tramadol-induced behavioral and neurochemical alterations in rats challenged across the forced swim despair test
Publication date: Available online 30 May 2016 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): Noha M. Gamil, Yousreya A. Maklad, Maha A.E. Ahmed, Shahira Nofal, Amany A.E. Ahmed Pain-associated depression is encountered clinically in some cases such as cancer, chronic neuropathy, and after operations. Tramadol is an opioid analgesic drug that may modulate monoaminergic neurotransmission by inhibition of noradrenaline and serotonin reuptake that may contribute to its antidepressant-like effects. Clinically, tramadol is used either alone or in combination with other NSAIDs in the treatmen...
Source: Beni Suef University Journal of Basic and Applied Sciences - May 30, 2016 Category: Science Source Type: research
Why We Study Sleep
This post is adapted from a speech delivered at a Fireside Chat between Arianna Huffington and Andre Iguodala on April 11, 2016 at Stanford University. You can watch the event here. Before introducing our famous guests, as director of the Center for Sleep Sciences and Medicine, I have been asked to introduce the topic of sleep and sleep disorders and why we should bother to study sleep. This is not difficult for me as sleep is my passion. The first reason for studying sleep is simply that sleep is one of the last remaining mysteries in biology. We still don't understand why a typical human has to spend 25 years of life sle...
Source: Science - The Huffington Post - April 14, 2016 Category: Science Source Type: news
Pinkies Up! There Could Be Some Real Health Benefits To Drinking Tea
Tea gets short shrift as coffee’s milder little sister. But these leaves may have a lot more to offer drinkers than just their subtle taste. Large, observational studies have found lifelong tea drinkers are less likely to face early cognitive decline and get certain types of cancer, stroke, coronary heart disease, and type 2 diabetes. We should also note that by “tea,” we mean the leaves from the Camellia sinensis plant that are plucked and processed in different ways to make black, green, white, oolong and pu’er teas -- not herbal infusions like peppermint, hibiscus and chamomile teas. Researchers ...
Source: Science - The Huffington Post - March 25, 2016 Category: Science Source Type: news
