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Total 240 results found since Jan 2013.
Endovascular Therapy is Effective for Large Vessel Occlusion Despite Concurrent Cancer
Ischemic stroke and concurrent cancer is increasingly recognized. However, optimal management is uncertain. As mechanical thrombectomy has become the standard of care for large vessel occlusion, more patients with cancer are presenting for embolectomy. However, it is unknown whether this subgroup has the same benefit profile described in multiple randomized trials for thrombectomy for large vessel occlusion. Our objective was to retrospectively evaluate a North American embolectomy database for safety and outcomes in patients with active cancer.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2022 Category: Neurology Authors: Thomas K. Mattingly, Jorge E. Risco, Jaclyn E. Burch, Raquel Whyte, Gurkirat S. Kohli, Stephen Susa, Tarun Bhalla, Matthew T. Bender Source Type: research
Characteristics of family nurse practitioners and their preparation for practice in rural vs urban employment settings
Approximately 50 million people, 20% of the population of the United States, live in areas designated as rural (U.S. Census Bureau, 2018). Rural Americans are more likely to die from heart disease, cancer, chronic lower respiratory disease, and stroke compared to their urban counterparts (Rural Health Information (RHI), 2019b). Deaths from unintentional injury are approximately 50% higher in rural areas (Cente rs for Disease Control and Prevention (CDC), 2017). Increasing rates of substance abuse disorders, depression, and suicidality in rural settings continue to outpace rates in urban settings (Gale, Janis, Coburn,& Rochford, 2019).
Source: Nursing Outlook - February 22, 2022 Category: Nursing Authors: Stacy M. Stellflug, Peter Buerhaus, David Auerbach Source Type: research
New ERLEADA ® (apalutamide) Analysis Demonstrates Rapid, Deep Prostate-Specific Antigen (PSA) Response in Patients with Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
SAN FRANCISCO, Feb. 14, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new real-world evidence data showing the initiation of ERLEADA® (apalutamide) results in high rates of rapid and deep prostate-specific antigen (PSA) response among patients with metastatic castration-sensitive prostate cancer (mCSPC). In a separate post-hoc analysis of the registrational Phase 3 SPARTAN and TITAN studies, rapid and deep PSA responses with ERLEADA® were associated with improvement in patient-reported outcomes (PROs) related to quality of life, physical wellbeing, pain, and fatigue intensity. The...
Source: Johnson and Johnson - February 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Understanding the relationship between perceived discrimination and mortality in United States adults
CONCLUSIONS: Adults experiencing lifetime and daily discrimination had significantly increased risk of mortality after adjusting for predisposing, enabling, and need factors. The findings highlight the importance of screening patients during clinical encounters for experiences of discrimination and providing appropriate resources to mitigate the negative impact of discriminatory events on mortality. Future research should work to fully understand the mechanism by which discrimination increases risk of mortality. These future findings should be used to develop targets for interventions designed to decrease mortality among a...
Source: Aging and Mental Health - February 4, 2022 Category: Geriatrics Authors: Joanna O Obaoye Aprill Z Dawson Madhuli Thakkar Joni S Williams Leonard E Egede Source Type: research
Pharmacotherapy of obesity in complex diseases
SummaryMore than 40% of adults in the United States suffer from obesity. Obesity is inextricably linked to many chronic illnesses like type-2 diabetes mellitus, hypertension, hyperlipidemia, heart disease, sleep apnea, stroke, and cancers. When used in combination with lifestyle modifications, pharmacotherapy has a vital role in treating obesity and improves short-term and long-term outcomes. A growing number of physicians are now interested in obesity medicine, and many of them are seeking guidance on how to treat complex patients with co-morbidities. This review provides a practical guide to the use of anti-obesity medic...
Source: Clinical Obesity - December 13, 2021 Category: Eating Disorders & Weight Management Authors: Vishnu Priya Pulipati,
Silvana Pannain Tags: Review Source Type: research
Couple and family interventions for high mortality health conditions: A strategic review (2010 –2019)
AbstractThe earliest publications in the field of marriage and family therapy introduced interventions conducted with families experiencing complex health conditions. This strategic review captures an evaluation of efficacy for 87 couple and family interventions published between 2010 and 2019 with a focus on the leading causes of mortality in the United States. These health conditions include chromosomal anomalies and accidents with infants aged 0 –4 years; accidents and cancer among children aged 5–14; accidents among adolescents aged 15–24; and heart disease, cancer, accidents, chronic lower respiratory diseases,...
Source: Journal of Marital and Family Therapy - November 6, 2021 Category: Psychiatry & Psychology Authors: Angela L. Lamson,
Jennifer L. Hodgson,
Keeley J. Pratt,
Tai J. Mendenhall,
Alison G. Wong,
Erin M. Sesemann,
Braden J. Brown,
Erika S. Taylor,
Jacqueline M. Williams ‐Reade,
Daniel J. Blocker,
Jennifer Harsh Caspari,
Max Zubatsky,
Matthew P. Tags: ORIGINAL ARTICLE Source Type: research
New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Bringing WISDOM to Breast Cancer Care
Dr. Laura Esserman answers the door of her bright yellow Victorian home in San Francisco’s Ashbury neighborhood with a phone at her ear. She’s wrapping up one of several meetings that day with her research team at University of California, San Francisco, where she heads the Carol Franc Buck Breast Care Center. She motions me in and reseats herself at a makeshift home office desk in her living room, sandwiched between a grand piano and set of enormous windows overlooking her front yard’s flower garden. It’s her remote base of operations when she’s not seeing patients or operating at the hospita...
Source: TIME: Health - October 22, 2021 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Source Type: news
Diagnostic reference levels and median doses for common clinical indications of CT: findings from an international registry
ConclusionsDRLs for CTDIvol and DLP for EUCLID clinical indications from diverse organizations were established and can contribute to dose optimization. These values were usually significantly higher in the US than in Europe.Key Points•Registry data were used to create benchmarks for 10 common indications for CT identified by the European Society of Radiology.•Observed US radiation doses were higher than European for 9 of 10 indications (except chronic sinusitis).•The presented diagnostic reference levels and median doses highlight potentially unnecessary variation in radiation dose.
Source: European Radiology - October 13, 2021 Category: Radiology Source Type: research
Aspirin Use to Prevent 1st Heart Attack or Stroke Should Be Curtailed, U.S. Panel Says
Adults at high risk for cardiovascular disease may face serious side effects if they start a daily regimen of low-dose aspirin.
Source: NYT Health - October 12, 2021 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: Aspirin Preventive Medicine Heart Colon and Colorectal Cancer Stroke Doctors Agency for Healthcare Research and Quality United States Preventive Services Task Force American College of Cardiology American Heart Assn your-feed-healthcar Source Type: news
Measuring the COVID-19 Mortality Burden in the United States : A Microsimulation Study
CONCLUSION: Beyond excess deaths alone, the COVID-19 pandemic imposed a greater life expectancy burden on persons aged 25 to 64 years, including those with average or above-average life expectancies, and a disproportionate burden on Black and Hispanic communities.PRIMARY FUNDING SOURCE: National Institute on Aging.PMID:34543588 | DOI:10.7326/M21-2239
Source: Annals of Internal Medicine - September 20, 2021 Category: Internal Medicine Authors: Julian Reif Hanke Heun-Johnson Bryan Tysinger Darius Lakdawalla Source Type: research
