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Total 356 results found since Jan 2013.
The role of STING signaling in central nervous system infection and neuroinflammatory disease
This article is categorized under:
Neurological Diseases> Molecular and Cellular Physiology
Infectious Diseases> Molecular and Cellular Physiology
Immune System Diseases> Molecular and Cellular Physiology
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - January 12, 2023 Category: Biomedical Science Authors: Lauren E. Fritsch,
Colin Kelly,
Alicia M. Pickrell Tags: Advanced Review Source Type: research
An Evidence-Based Review of Vitamin D for Common and High-Mortality Conditions
Conclusion:
Prospective studies of vitamin D supplementation demonstrate variable impact on disease specific and patient-oriented outcomes, suggesting a correlation but not a causal relationship between low vitamin D levels and disease pathogenicity. Future research should determine dosing standards and timing of vitamin D in treatment and prevention.
Source: Journal of the American Board of Family Medicine - December 23, 2022 Category: Primary Care Authors: Michael, W., Couture, A. D., Swedlund, M., Hampton, A., Eglash, A., Schrager, S. Tags: Clinical Review Source Type: research
Osteoporotic fracture admissions compared to other major medical admissions in Irish public hospitals
ConclusionOsteoporotic fractures represent a large and rapidly increasing illness burden amongst older Irish adults, with substantial care requirements and the resulting onus on our healthcare system. Urgent action is needed to address this public health issue and the services for those at risk of fracture.
Source: Archives of Osteoporosis - December 17, 2022 Category: Orthopaedics Source Type: research
What It ’s Like to Live With Stiff Person Syndrome
twIn an emotional social-media video posted Dec. 8, singer Celine Dion informed fans that she has been diagnosed with a rare neurological disease called stiff person syndrome. A diagnosis wasn’t easy or straightforward. “I’ve been dealing with problems with my health for a long time…we now know this is what’s been causing all of the spasms that I’ve been having,” said Dion, who is 54.
Here’s what to know about the condition and what it feels like.
What is stiff person syndrome?
According to the National Institute of Neurological Disorders and Stroke, stiff person syndrome has...
Source: TIME: Health - December 9, 2022 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Disease healthscienceclimate Source Type: news
Determining the safety and effectiveness of Tai Chi: a critical overview of 210 systematic reviews of controlled clinical trials
ConclusionsThe findings suggest Tai Chi has multidimensional effects, including physical, psychological and quality of life benefits for a wide range of conditions, as well as multimorbidity. Clinically important benefits were most consistently reported for Parkinson ’s disease, falls risk, knee osteoarthritis, low back pain, cerebrovascular, and cardiovascular diseases including hypertension. For most conditions, higher-quality SRs with rigorous primary studies are required.Systematic review registrationPROSPERO CRD42021225708.
Source: Systematic Reviews - December 3, 2022 Category: International Medicine & Public Health Source Type: research
PCR225 Quality of Life (QOL)-Related Mentions for Prevalent Diseases on Social Media Platforms in the US
People discuss online the impact of health conditions on their lives. Comparing ‘posts’ across diseases may provide an initial understanding of comparative disease burden on quality of life (QOL). For 8 of the most prevalent conditions in the USA (ischemic heart disease [IHD], low back pain, chronic obstructive pulmonary disease [COPD], diabetes mellitus [DM], lung cancer, stroke, depression, migraine), we identified the number of posts focused on QOL, examined the main topics/words used with the QOL term, and explored the proportion of posts with “positive” and “negative” sentiments.
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: O Onwude, M Casamayor, T Saraykar, R Shome, M Reaney Source Type: research
U.S. FDA Approves TECVAYLI ™ (teclistamab-cqyv), the First Bispecific T-cell Engager Antibody for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
HORSHAM, Pa., October 25, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) approved TECVAYLI™ (teclistamab-cqyv) for the treatment of adult patients with relapsed or refractory multiple myeloma, who previously received four or more prior lines of therapy, including a proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.1 TECVAYLI™ is a first-in-class, bispecific T-cell engager antibody that is administered as a subcutaneous treatment.1 This off-the-shelf (or ready to use) therapy uses innovative science to ac...
Source: Johnson and Johnson - October 25, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
A Case of Acute Cerebral Infarction With Chief Complaints of Abdominal Pain and Bloody Diarrhoea: The Power of a Patient-Centered Inclusive Diagnostic Team
We present the case of a 66-year-old man who presented with acute abdominal pain and bloody stool as his chief complaints and was finally diagnosed with ischemic colitis from colon cancer and acute cerebral infarction. Although several cognitive biases led to physicians missing the presence of acute stroke, a diagnostic team consisting of the patient, his family members, a ward nurse, and the physician worked effectively to reach the correct diagnosis soon after admission. A physician is not the only person involved in the diagnostic process. A patient-centered diagnostic team is necessary.PMID:36046325 | PMC:PMC9418667 | ...
Source: Pain Physician - September 1, 2022 Category: Anesthesiology Authors: Taichi Fujimori Tsunetaka Kijima Satoshi Honda Shingo Yamagata Tetsuya Makiishi Source Type: research
Male Sexual Dysfunction
Health Psychol Res. 2022 Aug 20;10(3):37533. doi: 10.52965/001c.37533. eCollection 2022.ABSTRACTMale sexual dysfunction is a series of conditions, most notably including erectile dysfunction (ED), Peyronie's disease (PD), and premature ejaculation (PE), defined by impaired sexual functioning. The prevalence of male sexual dysfunction increases with age and is relatively high with greater than 50% of men aged 40 to 70 describing some degree of erectile dysfunction. Risk factors for male sexual dysfunction include age, diabetes mellitus (DM), cancer, stroke, hypertension, penile trauma, depression, anxiety, and disturbance i...
Source: Pain Physician - August 24, 2022 Category: Anesthesiology Authors: Danyon Anderson John Laforge Maggie M Ross Robert Vanlangendonck Jamal Hasoon Omar Viswanath Alan D Kaye Ivan Urits Source Type: research
Late effects of childhood cancer recorded at a single outpatient clinic over the course of one year: implications for the follow-up care
Neoplasma. 2022 Jul 13:220531N584. doi: 10.4149/neo_2022_220531N584. Online ahead of print.ABSTRACTSystematic registration and analysis of detailed treatment data and data on late effects in survivors of childhood cancer are important both for building the evidence base for future assessment of current innovative therapies in pediatric oncology and for personalization of preventive care for survivors of childhood cancer. The paper provides a descriptive analysis of medical data (diagnosis, treatment, late effects, and health status) and selected patient-reported outcomes (mental health and psychosocial well-being) from a s...
Source: Neoplasma - July 12, 2022 Category: Cancer & Oncology Authors: Tomas Kepak Hana Hrstkova Vitezslav Dusek Marta Holikova Lucie Strublova Katerina Kepakova Source Type: research
