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Total 564 results found since Jan 2013.
Top 20 Research Studies of 2022 for Primary Care Physicians
This article summarizes the top 20 research studies of 2022 identified as POEMs (patient-oriented evidence that matters), excluding COVID-19. Statins for primary prevention of cardiovascular disease produce only a small absolute reduction in a person's likelihood of dying (0.6%), having a myocardial infarction (0.7%), or having a stroke (0.3%) over three to six years. Supplemental vitamin D does not reduce the risk of a fragility fracture, even in people with low baseline vitamin D levels or a previous fracture. Selective serotonin reuptake inhibitors are preferred medical therapy for panic disorder, and patients who disco...
Source: American Family Physician - April 13, 2023 Category: Primary Care Authors: Roland Grad Mark H Ebell Source Type: research
Cancers, Vol. 15, Pages 2077: Presence of Multi-Morbidities and Colorectal Cancer Screening Utilization among Breast Cancer Survivors
Conclusion: Among breast cancer survivors, multi-morbidities were positively associated with CRC screening.
Source: Cancers - March 30, 2023 Category: Cancer & Oncology Authors: Meng-Han Tsai Caitlyn Grunert Jacqueline B. Vo Justin X. Moore Avirup Guha Tags: Article Source Type: research
Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol
Stephanie Blendermann, 65, had good reason to worry about heart disease. Three of her sisters died in their 40s or early 50s from heart attacks, and her father needed surgery to bypass clogged arteries. She also suffered from an autoimmune disorder that results in chronic inflammation and boosts the odds of developing cardiovascular illnesses. “I have an interesting medical chart,” says Blendermann, a real estate agent in Prior Lake, Minnesota.
Yet Blendermann’s routine lab results weren’t alarming. At checkups, her low-density lipoprotein (LDL), or “bad,” cholesterol hovered around the 100 milligrams-per-...
Source: Science of Aging Knowledge Environment - March 16, 2023 Category: Geriatrics Source Type: research
Acori Tatarinowii Rhizoma: A comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity
Acori Tatarinowii Rhizoma (ATR, Shi Chang Pu in Chinese), a natural product with multiple targets in various diseases. This review provides the comprehensive summary of the chemical composition, pharmacological effects, pharmacokinetics parameters and toxicity of ATR. The results indicated that ATR possesses a wide spectrum of chemical composition, including volatile oil, terpenoids, organic acids, flavonoids, amino acids, lignin, carbohydrates and so on. Accumulating evidence from various studies has shown that ATR exerts a wide range of pharmacological properties, including protecting nerve cells, alleviating learning an...
Source: Frontiers in Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Source Type: research
New paradigms in purinergic receptor ligand discovery
Neuropharmacology. 2023 Mar 13:109503. doi: 10.1016/j.neuropharm.2023.109503. Online ahead of print.ABSTRACTThe discovery and clinical implementation of modulators of adenosine, P2Y and P2X receptors have progressed dramatically in ∼50 years since Burnstock's definition of purinergic signaling. Although most clinical trials of selective ligands (agonists and antagonists) of these nineteen receptors failed, there is a renewed impetus to redirect efforts to new disease conditions and the discovery of more selective or targeted compounds with potentially reduced side effects, such as biased GPCR agonists. The elucidation of...
Source: Neuropharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Kenneth A Jacobson Balaram Pradhan Zhiwei Wen Asmita Pramanik Source Type: research
Physical health risks of middle-aged people with low social independence: fatal diseases in men, and little attendance to cancer screenings in both sexes
CONCLUSIONS: In terms of current physical health, low-social-independent men have more fatal diseases. Both sexes with low social independence seldom attend cancer screenings and have an increased risk of developing progressive cancer in the future. At least in terms of non-smoking and non-drinking, they live healthier lives than the control group, and what makes low-social-independent men have various fatal diseases is still unclear.PMID:36846461 | PMC:PMC9948749 | DOI:10.7717/peerj.14904
Source: Cancer Control - February 27, 2023 Category: Cancer & Oncology Authors: Haruaki Naito Katsuya Nitta Misooja Lee Takeshi Ushigusa Motoki Osawa Takahiro Tabuchi Yasuhiro Kakiuchi Source Type: research
Reach and Impact of In-Person and Remote Delivery Formats of Walk with Ease
Inquiry. 2023 Jan-Dec;60:469580231152314. doi: 10.1177/00469580231152314.ABSTRACTThis descriptive study retrospectively evaluates the reach and impact of cohorts enrolled in Group (in-person, 2017-2020) and Self-Directed (remote, 2019-2020) delivery formats of the evidenced-based health promotion program, Walk with Ease, implemented statewide in North Carolina. An existing dataset consisting of pre- and post-surveys were analyzed for 1,890 participants; 454 (24%) from the Group format and 1,436 (76%) from Self-Directed. Self-Directed participants were younger, had more years of education, represented more Black/African Ame...
Source: Rural Remote Health - February 21, 2023 Category: Rural Health Authors: Nadia Z Mazza Amy Joy Lanou Serena Weisner Source Type: research
Does BMI Really Matter to Our Overall Health? Findings from a Cross-sectional Analysis of Middle-aged and Older Adults in India
AbstractWe explored the association of body mass index (BMI) with overall health among middle-aged and older Indian adults. The cross-sectional sample included 42,575 respondents (45 years) from the Longitudinal Aging Study in India (LASI), Wave 1 (2017-18), including middle-aged (23,811) and older adults (18,764). Overall health was assessed by using 19 health indicators, including 10 chronic diseases. Binary logistic regressions were utilized to examine the effect. The overweight and obese older adults were associated with higher life satisfaction (LS), happiness, better handgrip strength (HGS), better cognition (CS), an...
Source: Journal of Population Ageing - February 9, 2023 Category: International Medicine & Public Health Source Type: research
Is tooth loss associated with multiple chronic conditions?
CONCLUSION: Tooth loss could be an early marker for the co-occurrence of multiple chronic conditions among adults of working age. The association could be attributed to common risk factors for oral and general health.PMID:36634031 | DOI:10.1080/00016357.2023.2166986
Source: Acta Odontologica Scandinavica - January 12, 2023 Category: Dentistry Authors: Sara Hag Mohamed Wael Sabbah Source Type: research
