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Drug: Insulin
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Total 1848 results found since Jan 2013.
The impact of the metabolic score for insulin resistance on cardiovascular disease: a 10-year follow-up cohort study
ConclusionThe elevated METS-IR was independently associated with incident CVD, suggesting that the METS-IR might be a valuable indicator for risk stratification and early intervention of CVD.
Source: Journal of Endocrinological Investigation - February 17, 2023 Category: Endocrinology Source Type: research
Association between the triglyceride-glucose index and stroke in middle-aged and older non-diabetic population: A prospective cohort study
This study aimed to investigate the association between IR measured by the triglyceride-glucose (TyG) index and the risk of stroke among the middle-aged and elderly Chinese without diabetes.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 15, 2023 Category: Nutrition Authors: Yanbo Yu, Ying Meng, Jing Liu Source Type: research
New insights on the cardiovascular effects of IGF-1
DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.
Source: Frontiers in Endocrinology - February 9, 2023 Category: Endocrinology Source Type: research
Cardiovascular complications in insulin resistance and endocrine diseases
Endocr J. 2023 Feb 8. doi: 10.1507/endocrj.EJ22-0457. Online ahead of print.ABSTRACTCerebrovascular diseases, such as stroke and cardiovascular disease, are one of the leading causes of death in Japan. Type 2 diabetes is the most common form of diabetes and an important risk factor for these diseases. Among various pathological conditions associated with type 2 diabetes, insulin resistance has already been reported to be an important risk factor for diabetic complications. The major sites of insulin action in glucose metabolism in the body include the liver, skeletal muscle, and adipose tissue. However, insulin signaling m...
Source: Endocrine Journal - February 8, 2023 Category: Endocrinology Authors: Kyoichiro Tsuchiya Source Type: research
Novel biomarkers and emerging tools to identify causal molecular pathways in hypertension and associated cardiovascular diseases
Kardiol Pol. 2023 Feb 5. doi: 10.33963/KP.a2023.0037. Online ahead of print.ABSTRACTHypertension (HT) is a modifiable risk factor for life-threatening cardiovascular diseases (CVDs) including coronary artery disease, heart failure or stroke. Despite significant progress in understanding of the pathophysiological mechanisms of the disease, the molecular pathways targeted by HT treatment still remain largely unchanged. This warrants the necessity for searching novel biomarkers, which are causally related to persistent high blood pressure (BP) and may be pharmacologically targeted. Data from large-scale biobanks, containing h...
Source: Polish Heart Journal - February 5, 2023 Category: Cardiology Authors: Ewelina J ózefczuk Tomasz J Guzik Mateusz Siedlinski Source Type: research
A Novel Metabolic Score for Insulin Resistance and Symptomatic Intracranial Hemorrhage in Ischemic Stroke Patients After Endovascular Thrombectomy
Source: Neuropsychiatric Disease and Treatment - February 4, 2023 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Association of hyperuricemia with cardiovascular diseases: current evidence
Hosp Pract (1995). 2023 Feb 2. doi: 10.1080/21548331.2023.2173413. Online ahead of print.ABSTRACTThe aim of the present study is to present a historical and unified perspective on the association of serum uric acid (SUA) in the cause cardiovascular diseases (CVDs). The association of hyperuricemia (HUC) with CVD begun to be appreciated in the middle 1950s and early 1990s when clinical evidence was shown on the association of HUC with CVD. However, this association was disputed by several investigators including the Framingham group and by professional societies, like the American Heart Association and the American Society ...
Source: Atherosclerosis - February 2, 2023 Category: Cardiology Authors: Steven G Chrysant Source Type: research
Protective Roles of Adropin in Neurological Disease
Am J Physiol Cell Physiol. 2023 Jan 30. doi: 10.1152/ajpcell.00318.2022. Online ahead of print.ABSTRACTAdropin is a highly conserved secreted peptide encoded by the Energy Homeostasis Associated gene (Enho). It is expressed in many tissues throughout the body, including the liver and brain, and plays a crucial role in maintaining lipid homeostasis and regulating insulin sensitivity. Adropin also participates in several other pathophysiological processes of multiple central nervous system (CNS) diseases. There is strong evidence of the protective effects of adropin in stroke, heart disease, aging, and other diseases. The pe...
Source: Am J Physiol Cell Ph... - January 30, 2023 Category: Cytology Authors: Rachel E Gunraj Changjun Yang Lei Liu Jonathan Larochelle Eduardo Candelario-Jalil Source Type: research
