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Vaccination: Vaccines
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Total 86962 results found since Jan 2013.
A booster administration of the OKA/SK strain causes fatal disseminated varicella in an immunocompetent child
We report the first fatal case of VZV infection caused by OKA/SK strain contained in the vaccine administrated as a booster shot in an immunocompetent child, which has been independently developed from any currently available varicella vaccines that are OKA strain or MAV/06 strain based. The patient died due to sudden pulmonary alveolar hemorrhage as a secondary complication of VZV pneumonitis. Sequencing of the four SNPs unique to the OKA/SK strain (SNP loci 14 035T; 32 626C; 58 777G; 70 319G) enabled discrimination of the strain responsible for the disseminated infection. OKA/SK strain does not have any SNPs in ORF62 pos...
Source: Herpes - September 16, 2023 Category: Infectious Diseases Authors: Hyun Mi Kang Kyu Ri Kang Ye Ji Kim Jin Han Kang Soo-Young Lee Source Type: research
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Semin Immunol. 2023 Sep 14;70:101839. doi: 10.1016/j.smim.2023.101839. Online ahead of print.ABSTRACTIt is well-known that the functioning of the immune system gradually deteriorates with age, and we are increasingly confronted with its consequences as the life expectancy of the human population increases. Changes in the T-cell pool are among the most prominent features of the changing immune system during healthy ageing, and changes in the naive T-cell pool in particular are generally held responsible for its gradual deterioration. These changes in the naive T-cell pool are thought to be due to involution of the thymus. I...
Source: Seminars in Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Rob J de Boer Kiki Tesselaar Jos é A M Borghans Source Type: research
Conditional expression of NanoLuc luciferase through a multimodular system offers rapid detection of antimalarial drug activity
Exp Parasitol. 2023 Sep 14:108620. doi: 10.1016/j.exppara.2023.108620. Online ahead of print.ABSTRACTConditional gene expression is a powerful tool to investigate putative vaccine and drug targets, especially in a haploid organism such as Plasmodium falciparum. Inducible systems based on regulation of either transcription, translation, protein or mRNA stability, among others, allow switching on an off the expression of any desired gene causing specific gain or loss of function phenotypes. However, those systems can be cumbersome involving the construction of large plasmids and generation of multiple transgenic parasite lin...
Source: Experimental Parasitology - September 16, 2023 Category: Parasitology Authors: Caroline Lima Ignasi B Verdaguer Gerhard Wunderlich Alejandro M Katzin Brendan S Crabb Paul R Gilson Mauro F Azevedo Source Type: research
NLGN4X TCR transgenic T cells to treat gliomas
CONCLUSION: NLGN4X-TCR-T demonstrates efficacy in a preclinical glioblastoma model. On a global scale, we provide first evidence for the therapeutic retrieval of vaccine-induced human TCRs for the off-the-shelf treatment of glioblastoma patients.PMID:37715782 | DOI:10.1093/neuonc/noad172
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: C Kr ämer M Kilian Y C Chih A Kourtesakis D C Hoffmann T Boschert P Koopmann K Sanghvi A De Roia S Jung K J ähne B Day L D Shultz M Ratliff R Harbottle E W Green R Will W Wick M Platten L Bunse Source Type: research
COVID-19 vaccine effectiveness against hospitalizations in Paraguay, May 2021-April 2022: A test-negative design
CONCLUSIONS: This study contributes to our understanding of COVID-19 VE in Latin America and to global understanding of vaccines that have not been widely used in North America and Europe. VE estimates from Paraguay can parameterize models to estimate the impact of the national COVID-19 vaccination campaign in Paraguay and similar settings.PMID:37716830 | DOI:10.1016/j.vaccine.2023.09.015
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Sandra Irala Sarah Hamid Elena Penayo Fabiana Michel Paula Couto Cynthia Vazquez Mar ía José Ortega Chavely Dom ínguez Silvia Battaglia Marta Von Horoch Romeo Montoya Guillermo Sequera Francisco Nogareda Source Type: research
Evaluation of an iELISA for detection and quantification of rabies antibodies in domestic dog sera
Vaccine. 2023 Sep 14:S0264-410X(23)01058-7. doi: 10.1016/j.vaccine.2023.09.004. Online ahead of print.ABSTRACTMany rabies endemic-countries have recognized rabies as a public health problem that can be eliminated. As a result, some countries have started implementing small-scale vaccination programs with the aim of scaling them up. Post-vaccination serological monitoring is crucial to assess the efficacy of these programs. The recommended serological tests, the rapid fluorescent focus inhibition test, and the fluorescent antibody virus neutralization (FAVN) are accurate; however, the procedures require considerable experti...
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Ahmed Lugelo Katie Hampson Lorraine M McElhinney Felix Lankester Source Type: research
Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs
Vaccine. 2023 Sep 14:S0264-410X(23)01089-7. doi: 10.1016/j.vaccine.2023.09.019. Online ahead of print.ABSTRACTTick-borne encephalitis (TBE) is a severe neuroinfection of humans. Dogs are also commonly infected with tick-borne encephalitis virus (TBEV). These infections are usually asymptomatic, but sometimes show clinical signs similar to those seen in humans and can be fatal. To date, there is no TBEV vaccine available for use in dogs. To address this need, a TBEV vaccine candidate for dogs based on inactivated whole virus antigen was developed. The safety, immunogenicity, and efficacy of the vaccine candidate were tested...
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Jiri Salat Milan Hunady Pavel Svoboda Lucie Strelcova Petra Strakova Andrea Fortova Martin Palus Daniel Ruzek Source Type: research
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Semin Immunol. 2023 Sep 14;70:101839. doi: 10.1016/j.smim.2023.101839. Online ahead of print.ABSTRACTIt is well-known that the functioning of the immune system gradually deteriorates with age, and we are increasingly confronted with its consequences as the life expectancy of the human population increases. Changes in the T-cell pool are among the most prominent features of the changing immune system during healthy ageing, and changes in the naive T-cell pool in particular are generally held responsible for its gradual deterioration. These changes in the naive T-cell pool are thought to be due to involution of the thymus. I...
Source: Seminars in Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Rob J de Boer Kiki Tesselaar Jos é A M Borghans Source Type: research
Motivating vaccination with financial incentives
Trends Cogn Sci. 2023 Sep 14:S1364-6613(23)00171-7. doi: 10.1016/j.tics.2023.07.003. Online ahead of print.ABSTRACTGovernments and organizations often offer cash payments for vaccination. How effective are such payments? A literature review shows that incentives usually increase vaccination, especially for nonhesitant populations and when using guaranteed payments. Concerns about negative unintended consequences are unsupported. We also discuss open questions and avenues for future research.PMID:37716894 | DOI:10.1016/j.tics.2023.07.003
Source: Trends Cogn Sci - September 16, 2023 Category: Neuroscience Authors: Pol Campos-Mercade Armando N Meier Devin Pope Florian H Schneider Source Type: research
COVID-19 vaccine effectiveness against hospitalizations in Paraguay, May 2021-April 2022: A test-negative design
CONCLUSIONS: This study contributes to our understanding of COVID-19 VE in Latin America and to global understanding of vaccines that have not been widely used in North America and Europe. VE estimates from Paraguay can parameterize models to estimate the impact of the national COVID-19 vaccination campaign in Paraguay and similar settings.PMID:37716830 | DOI:10.1016/j.vaccine.2023.09.015
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Sandra Irala Sarah Hamid Elena Penayo Fabiana Michel Paula Couto Cynthia Vazquez Mar ía José Ortega Chavely Dom ínguez Silvia Battaglia Marta Von Horoch Romeo Montoya Guillermo Sequera Francisco Nogareda Source Type: research
Evaluation of an iELISA for detection and quantification of rabies antibodies in domestic dog sera
Vaccine. 2023 Sep 14:S0264-410X(23)01058-7. doi: 10.1016/j.vaccine.2023.09.004. Online ahead of print.ABSTRACTMany rabies endemic-countries have recognized rabies as a public health problem that can be eliminated. As a result, some countries have started implementing small-scale vaccination programs with the aim of scaling them up. Post-vaccination serological monitoring is crucial to assess the efficacy of these programs. The recommended serological tests, the rapid fluorescent focus inhibition test, and the fluorescent antibody virus neutralization (FAVN) are accurate; however, the procedures require considerable experti...
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Ahmed Lugelo Katie Hampson Lorraine M McElhinney Felix Lankester Source Type: research
Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs
Vaccine. 2023 Sep 14:S0264-410X(23)01089-7. doi: 10.1016/j.vaccine.2023.09.019. Online ahead of print.ABSTRACTTick-borne encephalitis (TBE) is a severe neuroinfection of humans. Dogs are also commonly infected with tick-borne encephalitis virus (TBEV). These infections are usually asymptomatic, but sometimes show clinical signs similar to those seen in humans and can be fatal. To date, there is no TBEV vaccine available for use in dogs. To address this need, a TBEV vaccine candidate for dogs based on inactivated whole virus antigen was developed. The safety, immunogenicity, and efficacy of the vaccine candidate were tested...
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Jiri Salat Milan Hunady Pavel Svoboda Lucie Strelcova Petra Strakova Andrea Fortova Martin Palus Daniel Ruzek Source Type: research
Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues
J Autoimmun. 2023 Sep 14;140:103094. doi: 10.1016/j.jaut.2023.103094. Online ahead of print.ABSTRACTSensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity balance are limited. Herein, two overlapping dominant peptides of myelin proteolipid protein, PLP136-150 and PLP139-151, which induce different forms of experimental autoimmune encephalomyelitis (EAE), monophasic and relapsing EAE, respectively, were investigated. Mice with ...
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Youwei Lin Shun Sakuraba Chandirasegaran Massilamany Jayagopala Reddy Yoshimasa Tanaka Sachiko Miyake Takashi Yamamura Source Type: research
Omega-3 polyunsaturated fatty acids and the psychiatric post-acute sequelae of COVID-19: A one-year retrospective cohort analysis of 33,908 patients
CONCLUSION: Omega-3 PUFAs may require re-evaluation as a preventive strategy against adverse mental health outcomes post-COVID-19 in placebo-controlled clinical trials.PMID:37716377 | DOI:10.1016/j.bbi.2023.09.008
Source: Brain, Behavior, and Immunity - September 16, 2023 Category: Neurology Authors: Ting-Hui Liu Chung-Han Ho Daniel Tzu-Li Chen Jheng-Yan Wu Po-Yu Huang Chih-Cheng Lai Kuang-Yang Hsieh Kuan-Pin Su Source Type: research
Examining the Influence of Imbalanced Social Contact Matrices in Epidemic Models
Am J Epidemiol. 2023 Sep 15:kwad185. doi: 10.1093/aje/kwad185. Online ahead of print.ABSTRACTTransmissible infections such as those caused by SARS-CoV-2 spread according to who contacts whom. Therefore, many epidemic models incorporate contact patterns through contact matrices. Contact matrices can be generated from social contact survey data. However, the resulting matrices are often imbalanced, such that the total number of contacts reported by group A with group B do not match those reported by group B with group A. We examine the theoretical influence of imbalanced contact matrices on the estimated basic reproduction n...
Source: Am J Epidemiol - September 16, 2023 Category: Epidemiology Authors: Mackenzie Hamilton Jesse Knight Sharmistha Mishra Source Type: research
