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Vaccination: Swine Flu (H1N1) Vaccine
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Total 733 results found since Jan 2013.
Influenza transmission during COVID-19 measures downscaling in Greece, August 2022: evidence for the need of continuous integrated surveillance of respiratory viruses
Euro Surveill. 2023 Jul;28(28):2200754. doi: 10.2807/1560-7917.ES.2023.28.28.2200754.ABSTRACTAfter the near absence of influenza and other respiratory viruses during the first 2 years of the COVID-19 pandemic, an increased activity of mainly influenza A(H3N2) was detected at the beginning of August 2022 in Greece on three islands. Of 33 cases with respiratory symptoms testing negative for SARS-CoV-2 with rapid antigen tests, 24 were positive for influenza: 20 as A(H3N2) subtype and four as A(H1N1)pdm09 subtype. Phylogenetic analysis of selected samples from both subtypes was performed and they fell into clusters within sub...
Source: Euro Surveill - July 13, 2023 Category: Infectious Diseases Authors: Kassiani Mellou Kyriaki Tryfinopoulou Mary Emmanouil Kassiani Gkolfinopoulou Spyros Sapounas Maria Evangelidou Panagiota Moulopoulou Eleftherios Miaoulis Emmanouil Angelakis George Sourvinos Theoklis Zaoutis Dimitrios Paraskevis Source Type: research
Humoral immune response following the inactivated quadrivalent influenza vaccination among HIV-infected and HIV-uninfected adults
CONCLUSION: Influenza vaccination of HIV-infected adults might be effective despite variable antibody responses. HIV-positive populations with CD4 + T cell counts ≤ 350 are less likely to achieve seroconversion. Further vaccination strategies could be developed for those with low CD4 T cell counts.PMID:37394372 | DOI:10.1016/j.vaccine.2023.05.055
Source: Vaccine - July 2, 2023 Category: Allergy & Immunology Authors: Zhaozhen Liu Can Pang Yuchuan Deng Caiping Guo Jia Li Yanping Li Ruolei Xin Xiyao Li Conghui Xu Chun Huang Hongyan Lu Jie Li Source Type: research
Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo
Int Immunopharmacol. 2023 Jun 29;122:110544. doi: 10.1016/j.intimp.2023.110544. Online ahead of print.ABSTRACTInfluenza A virus is an important respiratory pathogen that poses serious threats to human health. Owing to the high mutation rate of viral genes, weaker cross-protection of vaccines, and rapid emergence of drug resistance, there is an urgent need to develop new antiviral drugs against influenza viruses. Taurocholic acid is a primary bile acid that promotes digestion, absorption, and excretion of dietary lipids. Here, we demonstrate that sodium taurocholate hydrate (STH) exhibits broad-spectrum antiviral activity a...
Source: International Immunopharmacology - July 1, 2023 Category: Allergy & Immunology Authors: Xiaolu Sun Xiaotong Hu Qiang Zhang Li Zhao Xiaomei Sun Li Yang Meilin Jin Source Type: research
Influenza vaccine effectiveness in preventing hospital encounters for laboratory-confirmed infection among Italian adults, 2022/23 season
In conclusion, the 2022/23 SIV was moderately effective against hospital encounters for laboratory-confirmed influenza.PMID:37385889 | DOI:10.1016/j.vaccine.2023.06.072
Source: Vaccine - June 29, 2023 Category: Allergy & Immunology Authors: Alexander Domnich Andrea Orsi Matilde Ogliastro Carlo-Simone Trombetta Marianna Scarpaleggia Federica Stefanelli Donatella Panatto Bianca Bruzzone Giancarlo Icardi Source Type: research
Assessing the stability-indicating properties of alternative potency assays for inactivated influenza vaccine
Vaccine. 2023 Jun 19:S0264-410X(23)00726-0. doi: 10.1016/j.vaccine.2023.06.051. Online ahead of print.ABSTRACTDetermination of the potency of a vaccine is critical to ensuring that an appropriate dose is delivered, lot-to-lot consistency is maintained, and that the formulation is stable over the life of the vaccine. The potency of inactivated influenza vaccines is determined routinely by the Single Radial Immunodiffusion (SRID) assay. A number of alternative potency assays have been proposed and have been under evaluation in recent years. The aim of this study was to compare a surface plasmon resonance-based assay and two ...
Source: Vaccine - June 21, 2023 Category: Allergy & Immunology Authors: Aleksei Ekimov Arun B Arunachalam Taylor Blake Jesse Bodle Laura Couzens Sitara Dubey Maryna Eichelberger Othmar G Engelhardt Francesco Gubinelli Manju Joshi Darya Melnyk Giuseppe Palladino Peter Rigsby Steven Rockman Natalya Savina Elena Smith Shawn A N Source Type: research
Barriers to and facilitators of populational adherence to prevention and control measures of COVID-19 and other respiratory infectious diseases: a qualitative evidence synthesis
CONCLUSIONS: This review suggests that financial and social support, assertive communication, trust in political authorities and greater regulation of social media enhance adherence to prevention and control measures for COVID-19 and infectious respiratory diseases. Designing and implementing effective educational public health interventions targeting the findings of barriers and facilitators highlighted in this review are key to reducing the impact of infectious respiratory diseases at the population level.PMID:37343960 | DOI:10.1183/16000617.0238-2022
Source: Respiratory Care - June 21, 2023 Category: Respiratory Medicine Authors: T ácito Zaildo Thayla Amorim Santino Gabriela Chaves Baldomero Antonio Kato da Silva Jo ão Carlos Alchieri Cecilia M Patino Sarah Leite Kleber Giovanni Luz Ricardo Oliveira Guerra Tito Hugo Soares da Penha Gabriel Rodrigues da Silva Ada Cristina J ácom Source Type: research
Assessing the stability-indicating properties of alternative potency assays for inactivated influenza vaccine
Vaccine. 2023 Jun 19:S0264-410X(23)00726-0. doi: 10.1016/j.vaccine.2023.06.051. Online ahead of print.ABSTRACTDetermination of the potency of a vaccine is critical to ensuring that an appropriate dose is delivered, lot-to-lot consistency is maintained, and that the formulation is stable over the life of the vaccine. The potency of inactivated influenza vaccines is determined routinely by the Single Radial Immunodiffusion (SRID) assay. A number of alternative potency assays have been proposed and have been under evaluation in recent years. The aim of this study was to compare a surface plasmon resonance-based assay and two ...
Source: Vaccine - June 21, 2023 Category: Allergy & Immunology Authors: Aleksei Ekimov Arun B Arunachalam Taylor Blake Jesse Bodle Laura Couzens Sitara Dubey Maryna Eichelberger Othmar G Engelhardt Francesco Gubinelli Manju Joshi Darya Melnyk Giuseppe Palladino Peter Rigsby Steven Rockman Natalya Savina Elena Smith Shawn A N Source Type: research
Barriers to and facilitators of populational adherence to prevention and control measures of COVID-19 and other respiratory infectious diseases: a qualitative evidence synthesis
Conclusions:
This review suggests that financial and social support, assertive communication, trust in political authorities and greater regulation of social media enhance adherence to prevention and control measures for COVID-19 and infectious respiratory diseases. Designing and implementing effective educational public health interventions targeting the findings of barriers and facilitators highlighted in this review are key to reducing the impact of infectious respiratory diseases at the population level.
Source: European Respiratory Review - June 21, 2023 Category: Respiratory Medicine Authors: Zaildo, T., Santino, T. A., Chaves, G., da Silva, B. A. K., Alchieri, J. C., Patino, C. M., Leite, S., Luz, K. G., Guerra, R. O., da Penha, T. H. S., da Silva, G. R., Jacome, A. C., Monteiro, K. S., de Mendonca, K. M. P. P. Tags: Respiratory infections and tuberculosis Reviews Source Type: research
Post-fusion influenza vaccine adjuvanted with SA-2 confers heterologous protection via Th1-polarized, non-neutralizing antibody responses
Vaccine. 2023 Jun 15:S0264-410X(23)00685-0. doi: 10.1016/j.vaccine.2023.06.019. Online ahead of print.ABSTRACTDevelopment of a universal influenza vaccine that can provide robust and long-lasting protection against heterologous infections is a global public health priority. A variety of vaccine antigens are designed to increase the antigenicity of conserved epitopes to elicit cross-protective antibodies that often lack virus-neutralizing activity. Given the contribution of antibody effector functions to cross-protection, adjuvants need to be added to modulate antibody effector functions as well as to enhance antibody quant...
Source: Vaccine - June 17, 2023 Category: Allergy & Immunology Authors: Ayae Nishiyama Yu Adachi Keisuke Tonouchi Saya Moriyama Lin Sun Masamitsu Aoki Hideki Asanuma Masayuki Shirakura Akihisa Fukushima Takuya Yamamoto Yoshimasa Takahashi Source Type: research
Could chatbots help devise the next pandemic virus?
Tech experts have been sounding the alarm that artificial intelligence (AI) could turn against humanity by taking over everything from business to warfare. Now, Kevin Esvelt is adding another worry: AI could help somebody with no science background and evil intentions design and order a virus capable of unleashing a pandemic.
Esvelt, a biosecurity expert at the Massachusetts Institute of Technology, recently asked students to create a dangerous virus with the help of ChatGPT or other so-called large language models, systems that can generate humanlike responses to broad questions based on vast training sets of interne...
Source: ScienceNOW - June 14, 2023 Category: Science Source Type: news
Construction of an inhalable recombinant M2e-FP-expressing Bacillus subtilis spores-based vaccine and evaluation of its protection efficacy against influenza in a mouse model
Vaccine. 2023 Jun 10:S0264-410X(23)00655-2. doi: 10.1016/j.vaccine.2023.05.074. Online ahead of print.ABSTRACTInfluenza A virus (IAV) is a deadly zoonotic pathogen that remains a burden to global health systems despite continuous vaccinations, indicating the need for an improved vaccine strategy. In this work, we constructed a new recombinant influenza vaccine using Bacillus subtilis spores expressing M2e-FP protein (RSM2eFP) and assessed its potency and efficacy in BALB/c mouse immunized via aerosolized intratracheal inoculation (i.t.) or intragastric (i.g.) administration. Immunization via i.t. route conferred 100 % prot...
Source: Vaccine - June 12, 2023 Category: Allergy & Immunology Authors: Di Ma Shengyuan Tian Qingqing Qin Yonghui Yu Jun Jiao Xiaolu Xiong Yan Guo Xingxiao Zhang Xuan Ouyang Source Type: research
