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Abietane Diterpenoids Isolated from < em > Torreya nucifera < /em > Disrupt Replication of Influenza Virus by Blocking the Phosphatidylinositol-3-Kinase (PI3K)-Akt and ERK Signaling Pathway
Curr Issues Mol Biol. 2023 Mar 9;45(3):2284-2295. doi: 10.3390/cimb45030147.ABSTRACTAlthough vaccines and antiviral drugs are available, influenza viruses continue to pose a significant threat to vulnerable populations globally. With the emergence of drug-resistant strains, there is a growing need for novel antiviral therapeutic approaches. We found that 18-hydroxyferruginol (1) and 18-oxoferruginol (2) isolated from Torreya nucifera exhibited strong anti-influenza activity, with 50% inhibitory concentration values of 13.6 and 18.3 μM against H1N1, 12.8 and 10.8 μM against H9N2, and 29.2 μM (only compound 2) against H3N...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Jaehoon Bae Hyung-Jun Kwon Ji Sun Park Jinseok Jung Young Bae Ryu Woo Sik Kim Ju Huck Lee Jae-Ho Jeong Jae Sung Lim Woo Song Lee Su-Jin Park Source Type: research
