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Therapy: Antiviral Therapy
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CROI 2023: Advances in Antiviral Therapy in HIV and Viral Hepatitis
Top Antivir Med. 2023 May;31(3):445-467.ABSTRACTSeveral innovative methods were presented at the 2023 Conference on Retroviruses and Opportunistic Infections (CROI) targeting different aspects of the HIV care continuum to improve testing, linkage to care, and viral suppression. Some of these approaches were directed at more vulnerable groups, such as pregnant women, adolescents, and individuals who inject drugs. In contrast was the devastating impact of the COVID-19 pandemic, with negative outcomes on HIV viral load suppression and retention in care. Data were presented on hepatitis B virus (HBV) suppression showing that t...
Source: Topics in HIV Medicine - June 14, 2023 Category: Infectious Diseases Authors: Shauna H Gunaratne Barbara S Taylor Timothy J Wilkin Hong-Van Tieu Source Type: research
< em > Curcuma Longa < /em > Induces the Transcription Factor FOXP3 to Downregulate Human Chemokine CCR5 Expression and Inhibit HIV-1 Infection
Am J Chin Med. 2023 Jun 14:1-21. doi: 10.1142/S0192415X23500544. Online ahead of print.ABSTRACTHIV mutations occur frequently despite the substantial success of combination antiretroviral therapy, which significantly impairs HIV progression. Failure to develop specific vaccines, the occurrence of drug-resistant strains, and the high incidence of adverse effects due to combination antiviral therapy regimens call for novel and safer antivirals. Natural products are an important source of new anti-infective agents. For instance, curcumin inhibits HIV and inflammation in cell culture assays. Curcumin, the principal constituent...
Source: The American Journal of Chinese Medicine - June 14, 2023 Category: Complementary Medicine Authors: Long Feng Wu-Hao Lu Qing-Ya Li Hai-Yan Zhang Li-Ran Xu Wen-Qiao Zang Wen-Tao Guo Yan-Fang Li Wen-Jin Zheng Yu-Xuan Geng Qing Li Yu-Han Liu Source Type: research
CROI 2023: Advances in Antiviral Therapy in HIV and Viral Hepatitis
Top Antivir Med. 2023 May;31(3):445-467.ABSTRACTSeveral innovative methods were presented at the 2023 Conference on Retroviruses and Opportunistic Infections (CROI) targeting different aspects of the HIV care continuum to improve testing, linkage to care, and viral suppression. Some of these approaches were directed at more vulnerable groups, such as pregnant women, adolescents, and individuals who inject drugs. In contrast was the devastating impact of the COVID-19 pandemic, with negative outcomes on HIV viral load suppression and retention in care. Data were presented on hepatitis B virus (HBV) suppression showing that t...
Source: Topics in HIV Medicine - June 14, 2023 Category: Infectious Diseases Authors: Shauna H Gunaratne Barbara S Taylor Timothy J Wilkin Hong-Van Tieu Source Type: research
< em > Curcuma Longa < /em > Induces the Transcription Factor FOXP3 to Downregulate Human Chemokine CCR5 Expression and Inhibit HIV-1 Infection
Am J Chin Med. 2023 Jun 14:1-21. doi: 10.1142/S0192415X23500544. Online ahead of print.ABSTRACTHIV mutations occur frequently despite the substantial success of combination antiretroviral therapy, which significantly impairs HIV progression. Failure to develop specific vaccines, the occurrence of drug-resistant strains, and the high incidence of adverse effects due to combination antiviral therapy regimens call for novel and safer antivirals. Natural products are an important source of new anti-infective agents. For instance, curcumin inhibits HIV and inflammation in cell culture assays. Curcumin, the principal constituent...
Source: Molecular Medicine - June 14, 2023 Category: Molecular Biology Authors: Long Feng Wu-Hao Lu Qing-Ya Li Hai-Yan Zhang Li-Ran Xu Wen-Qiao Zang Wen-Tao Guo Yan-Fang Li Wen-Jin Zheng Yu-Xuan Geng Qing Li Yu-Han Liu Source Type: research
CROI 2023: Advances in Antiviral Therapy in HIV and Viral Hepatitis
Top Antivir Med. 2023 May;31(3):445-467.ABSTRACTSeveral innovative methods were presented at the 2023 Conference on Retroviruses and Opportunistic Infections (CROI) targeting different aspects of the HIV care continuum to improve testing, linkage to care, and viral suppression. Some of these approaches were directed at more vulnerable groups, such as pregnant women, adolescents, and individuals who inject drugs. In contrast was the devastating impact of the COVID-19 pandemic, with negative outcomes on HIV viral load suppression and retention in care. Data were presented on hepatitis B virus (HBV) suppression showing that t...
Source: Topics in HIV Medicine - June 14, 2023 Category: Infectious Diseases Authors: Shauna H Gunaratne Barbara S Taylor Timothy J Wilkin Hong-Van Tieu Source Type: research
Antivirals for prevention of hepatitis B virus mother-to-child transmission in human immunodeficiency virus positive pregnant women co-infected with hepatitis B virus
CONCLUSIONS: We do not know what the effects of tenofovir-based antiviral combination regimens are on all-cause infant mortality, proportion of infants with serious adverse events and proportion of mothers with serious adverse events, proportion of infants with adverse events not considered serious, and proportion of mothers with detectable HBV DNA before delivery because the certainty of evidence was very low. Only one or two trials, with insufficient power, contributed data for analyses. We lack randomised clinical trials at low risk of systematic and random errors, and fully reporting all-cause infant mortality, serious...
Source: Cochrane Database of Systematic Reviews - June 12, 2023 Category: General Medicine Authors: Emmanuel O Ugwu George U Eleje Angela O Ugwu Uchenna I Nwagha Joseph I Ikechebelu Uchenna A Umeh Henrietta U Okafor Source Type: research
