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Specialty: Genetics & Stem Cells
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Total 47651 results found since Jan 2013.
Application of Multiple Omics to Understand Postoperative Delirium Pathophysiology in Humans
Gerontology. 2023 Sep 18. doi: 10.1159/000533789. Online ahead of print.ABSTRACTDelirium, an acute change in cognition, is common, morbid, and costly, particularly among hospitalized older adults. Despite growing knowledge of its epidemiology, far less is known about delirium pathophysiology. Initial work understanding delirium pathogenesis has focused on assaying single or a limited subset of molecules or genetic loci. Recent technological advances at the forefront of biomarker and drug target discovery have facilitated application of multiple "omics" approaches aimed to provide a more complete understanding of complex di...
Source: Genomics Proteomics ... - September 18, 2023 Category: Genetics & Stem Cells Authors: Sarinnapha M Vasunilashorn Simon T Dillon Edward R Marcantonio Towia A Libermann Source Type: research
Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies
Chromosome Res. 2023 Sep 18;31(4):28. doi: 10.1007/s10577-023-09737-5.ABSTRACTAneuploidy is defined as the cellular state of having a number of chromosomes that deviates from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy can be present in a static state: Down syndrome individuals stably maintain an extra copy of chromosome 21 in their cells. In cancer cells, however, aneuploidy is usually present in combination with chromosomal instability (CIN) which leads to a continual generation of new chromosomal alterations and the development of intratumour heterogeneity (ITH). The prevalence of ...
Source: Chromosome Research - September 18, 2023 Category: Genetics & Stem Cells Authors: Joana Reis Andrade Annie Dinky Gallagher Jovanna Maharaj Sarah Elizabeth McClelland Source Type: research
Expression profiles of lncRNAs, miRNAs, and mRNAs during the proliferative phase of liver regeneration in mice with liver fibrosis
Genomics. 2023 Sep 16;115(5):110707. doi: 10.1016/j.ygeno.2023.110707. Online ahead of print.ABSTRACTThe role of lncRNAs in the regeneration of fibrotic liver is unclear. To address this issue, we established a 70% hepatectomy model of liver fibrosis in mice, used high-throughput sequencing technology to obtain the expression profiles of lncRNAs, miRNAs, and mRNAs, and constructed a lncRNA-miRNA-mRNA regulatory network. A total of 1329 lncRNAs, 167 miRNAs, and 6458 mRNAs were differentially expressed. On this basis, a lncRNA-miRNA-mRNA ceRNA regulatory network consisting of 38 DE lncRNAs, 24 DE miRNAs, and 299 DE mRNAs was...
Source: Genomics - September 18, 2023 Category: Genetics & Stem Cells Authors: Xiao-Ming Dai Zhang-Tao Long Feng-Feng Zhu Hua-Jian Li Zhi-Qiang Xiang Ya-Chen Wu Hao Liang Qian Wang Zhu Zhu Source Type: research
Potential selection for lipid kinase activity and spermatogenesis in Henan native pig breeds and growth shaping by introgression of European genes
CONCLUSIONS: Admixture of North China, East China and foreign pigs contributed to high genetic diversity of Henan local pigs. Ontology terms associated with lipid kinase activity and spermatogenesis and growth shaping by introgression of European genes in Henan pigs were identified through selective sweep analyses.PMID:37723431 | PMC:PMC10506266 | DOI:10.1186/s12711-023-00841-y
Source: Genet Sel Evol - September 18, 2023 Category: Genetics & Stem Cells Authors: Ruimin Qiao Xinjian Li Ole Madsen Martien A M Groenen Pan Xu Kejun Wang Xuelei Han Gaiying Li Xiuling Li Kui Li Source Type: research
Genetic analysis of geometric morphometric 3D visuals of French jumping horses
CONCLUSIONS: The main application of 3D morphometric analysis is the ability to define the estimated breeding value (EBV) of a sire based on the shape of its potential progeny, which is easier for breeders to visualize in a single synthetic image than a full description based on linear profiling. However, the acceptance of these new phenotypes by breeders and the complex nature of summarized shapes may be challenging. Due to the low genetic correlations of the summarized shapes with jumping performance, the methodology did not allow indirect performance selection criteria to be defined.PMID:37723416 | PMC:PMC10506242 | DOI...
Source: Genet Sel Evol - September 18, 2023 Category: Genetics & Stem Cells Authors: Anne Ricard Nathalie Crevier-Denoix Philippe Pourcelot Harmony Crichan Margot Sabbagh Bernard Dumont-Saint-Priest Sophie Danvy Source Type: research
Genetic clues to reprogramming power and formation of mouse oocyte
Curr Opin Genet Dev. 2023 Sep 16;83:102110. doi: 10.1016/j.gde.2023.102110. Online ahead of print.ABSTRACTOocyte features the unique capacity to reprogram not only sperm but also somatic nuclei to totipotency, yet the scarcity of oocytes has hindered the exploration and application of their reprogramming ability. In the meanwhile, the formation of oocytes, which involves extensive intracellular alterations and interactions, has also attracted tremendous interest. This review discusses developmental principles and regulatory mechanisms associated with ooplasm reprogramming and oocyte formation from a genetic perspective, wi...
Source: Current Opinion in Genetics and Development - September 18, 2023 Category: Genetics & Stem Cells Authors: Bo Chen Duanqing Pei Source Type: research
Programmed Cell Death in Unicellular Versus Multicellular Organisms
Annu Rev Genet. 2023 Sep 18. doi: 10.1146/annurev-genet-033123-095833. Online ahead of print.ABSTRACTProgrammed cell death (self-induced) is intrinsic to all cellular life forms, including unicellular organisms. However, cell death research has focused on animal models to understand cancer, degenerative disorders, and developmental processes. Recently delineated suicidal death mechanisms in bacteria and fungi have revealed ancient origins of animal cell death that are intertwined with immune mechanisms, allaying earlier doubts that self-inflicted cell death pathways exist in microorganisms. Approximately 20 mammalian death...
Source: Annual Review of Genetics - September 18, 2023 Category: Genetics & Stem Cells Authors: Madhura Kulkarni J Marie Hardwick Source Type: research
RNA Repair: Hiding in Plain Sight
Annu Rev Genet. 2023 Sep 18. doi: 10.1146/annurev-genet-071719-021856. Online ahead of print.ABSTRACTEnzymes that phosphorylate, dephosphorylate, and ligate RNA 5' and 3' ends were discovered more than half a century ago and were eventually shown to repair purposeful site-specific endonucleolytic breaks in the RNA phosphodiester backbone. The pace of discovery and characterization of new candidate RNA repair activities in taxa from all phylogenetic domains greatly exceeds our understanding of the biological pathways in which they act. The key questions anent RNA break repair in vivo are (a) identifying the triggers, agents...
Source: Annual Review of Genetics - September 18, 2023 Category: Genetics & Stem Cells Authors: Stewart Shuman Source Type: research
Unlocking the Complex Cell Biology of Coral-Dinoflagellate Symbiosis: A Model Systems Approach
Annu Rev Genet. 2023 Sep 18. doi: 10.1146/annurev-genet-072320-125436. Online ahead of print.ABSTRACTSymbiotic interactions occur in all domains of life, providing organisms with resources to adapt to new habitats. A prime example is the endosymbiosis between corals and photosynthetic dinoflagellates. Eukaryotic dinoflagellate symbionts reside inside coral cells and transfer essential nutrients to their hosts, driving the productivity of the most biodiverse marine ecosystem. Recent advances in molecular and genomic characterization have revealed symbiosis-specific genes and mechanisms shared among symbiotic cnidarians. In ...
Source: Annual Review of Genetics - September 18, 2023 Category: Genetics & Stem Cells Authors: Marie R Jacobovitz Elizabeth A Hambleton Annika Guse Source Type: research
Manipulating the Destiny of Wild Populations Using CRISPR
Annu Rev Genet. 2023 Sep 18. doi: 10.1146/annurev-genet-031623-105059. Online ahead of print.ABSTRACTGenetic biocontrol aims to suppress or modify populations of species to protect public health, agriculture, and biodiversity. Advancements in genome engineering technologies have fueled a surge in research in this field, with one gene editing technology, CRISPR, leading the charge. This review focuses on the current state of CRISPR technologies for genetic biocontrol of pests and highlights the progress and ongoing challenges of using these approaches. Expected final online publication date for the Annual Review of Genetics...
Source: Annual Review of Genetics - September 18, 2023 Category: Genetics & Stem Cells Authors: Robyn Raban John M Marshall Bruce A Hay Omar S Akbari Source Type: research
Genetic diversity and molecular evolution of Seoul virus in Hebei province, China
Infect Genet Evol. 2023 Sep 15:105503. doi: 10.1016/j.meegid.2023.105503. Online ahead of print.ABSTRACTSeoul virus (SEOV) is a major pathogen which causes hemorrhagic fever with renal syndrome (HFRS), and is present all over the world. However, there are currently few long-term systematic studies of SEOV's phylogenetic and evolutionary mechanisms in epidemic areas. Thus, in this study, we used RT-PCR combined with NGS to obtain the genomes of six SEOV viruses from 1993, as well as 56 Hebei province-specific tissue samples from 1999 to 2022. Phylogenetic analysis showed that the SEOV samples could be divided into seven gro...
Source: Infection, Genetics and Evolution - September 17, 2023 Category: Genetics & Stem Cells Authors: Yamei Wei Yanan Cai Xu Han Zhanying Han Yanbo Zhang Yonggang Xu Qi Li Source Type: research
miR-125b-5p-MAPK1-C/EBP α feedback loop regulates all-trans retinoic acid resistance in acute promyelocytic leukemia
Gene. 2023 Sep 15:147806. doi: 10.1016/j.gene.2023.147806. Online ahead of print.NO ABSTRACTPMID:37717613 | DOI:10.1016/j.gene.2023.147806
Source: Gene - September 17, 2023 Category: Genetics & Stem Cells Authors: Wenjuan Jiang Yongkang Hu Xian Wang Qi Zhang Xinlong Guo Siyu Cheng Langqun Chen Jiahui Ying Liang Zhang Baoping Jiang Source Type: research
Synthesis of fluorinated and nonfluorinated sugar alkenylphosphonates via highly stereoselective Horner-Wadsworth-Emmons olefination
Carbohydr Res. 2023 Sep 13;533:108941. doi: 10.1016/j.carres.2023.108941. Online ahead of print.ABSTRACTNew fluorinated and nonfluorinated sugar alkenylphosphonates were obtained. In all cases 1,2;5,6-di-O-isopropylidene-α-d-glucofuranose was used as the starting material. The synthesis of alkenylphosphonates was based on Horner-Wadsworth-Emmons olefination. The process led to products with E-stereochemistry exclusively or predominately.PMID:37717483 | DOI:10.1016/j.carres.2023.108941
Source: Carbohydrate Research - September 17, 2023 Category: Genetics & Stem Cells Authors: Monika Bilska-Markowska Marcin Ka źmierczak Source Type: research
Water-soluble fluorine-functionalized chitooligosaccharide derivatives: Synthesis, characterization and antimicrobial activity
Carbohydr Res. 2023 Sep 4;533:108935. doi: 10.1016/j.carres.2023.108935. Online ahead of print.ABSTRACTIn this work, a series of water-soluble fluorine-functionalized chitooligosaccharide derivatives were synthesized by conjugating nicotinic acid to chitooligosaccharide via nicotinylation reaction, followed by nucleophilic reaction with ethyl bromide, benzyl bromide and fluorobenzyl bromides. Synthesized derivatives were identified structurally by Fourier Transform Infrared Spectroscopy and Nuclear Magnetic Resonance. In addition, the antibacterial activities of chitooligosaccharide derivatives against several disease-caus...
Source: Carbohydrate Research - September 17, 2023 Category: Genetics & Stem Cells Authors: Conghao Lin Fang Luan Shengjia Su Aili Jiang Wenqiang Tan Zhanyong Guo Source Type: research
Two novel heterozygous variants in RecA2 domain of the DHX37 cause 46,XY gonadal dysgenesis and testicular regression syndrome
CONCLUSION: Our findings broaden the variant spectrum of DHX37 in 46,XY DSD individuals.PMID:37717579 | DOI:10.1159/000534086
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - September 17, 2023 Category: Genetics & Stem Cells Authors: Hao Yang Xiuqi Ma Hongjuan Tian Jinna Yuan Dehua Wu Guanping Dong Qian Liu Junfen Fu Source Type: research
