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Total 47651 results found since Jan 2013.
Alzheimer's Disease as A Viral Infectious Disease: Revisiting the Infectious Hypothesis
Ageing Res Rev. 2023 Sep 11:102068. doi: 10.1016/j.arr.2023.102068. Online ahead of print.ABSTRACTAlzheimer's disease (AD) represents the most frequent type of dementia in elderly people. Two major forms of the disease exist: sporadic - the causes of which have not yet been fully understood - and familial - inherited within families from generation to generation, with a clear autosomal dominant transmission of mutations in Presenilin 1 (PSEN1), 2 (PSEN2) or Amyloid Precursors Protein (APP) genes. The main hallmark of AD consists of extracellular deposits of amyloid-beta (Aβ) peptide and intracellular deposits of the hyper...
Source: Ageing Research Reviews - September 13, 2023 Category: Genetics & Stem Cells Authors: Francesco Bruno Paolo Abondio Rossella Bruno Leognano Ceraudo Ersilia Pararazzo Luigi Citrigno Donata Luiselli Amalia C Bruni Giuseppe Passarino Rosanna Colao Raffaele Maletta Alberto Montesanto Source Type: research
Cernunnos deficiency: Further delineation in 5 Egyptian patients
In conclusion, Cernunnos deficiency can have a wide range of clinical features. The characteristic immune profile including a decrease in recent thymic emigrants and naive T cells, markedly elevated memory T cells together with normal to high IgM, and a decrease in IgG and IgA. This immune profile is highly suggestive of Cernunnos deficiency in T-B-NK + SCID patients especially surviving for older ages.PMID:37703920 | DOI:10.1016/j.ejmg.2023.104840
Source: European Journal of Medical Genetics - September 13, 2023 Category: Genetics & Stem Cells Authors: Rabab El Hawary Safa Meshaal Sohilla Lotfy Dalia Abd Elaziz Radwa Alkady Alia Eldash Aya Erfan Engy Chohayeb Mai Saad Rania Darwish Jeannette Boutros Nermeen Galal Aisha Elmarsafy Source Type: research
New perspectives on the causes and consequences of male meiotic drive
Curr Opin Genet Dev. 2023 Sep 11:102111. doi: 10.1016/j.gde.2023.102111. Online ahead of print.ABSTRACTGametogenesis is vulnerable to selfish genetic elements that bias their transmission to the next generation by cheating meiosis. These so-called meiotic drivers are widespread in plants, animals, and fungi and can impact genome evolution. Here, we summarize recent progress on the causes and consequences of meiotic drive in males, where selfish elements attack vulnerabilities in spermatogenesis. Advances in genomics provide new insights into the organization and dynamics of driving chromosomes in natural populations. Commo...
Source: Current Opinion in Genetics and Development - September 13, 2023 Category: Genetics & Stem Cells Authors: C écile Courret Xiaolu Wei Amanda M Larracuente Source Type: research
CRISPR-Cas systems and diversity of targeting phages in Lactobacillus johnsonii strains; insights from genome mining approach
In conclusion, the current study indicates that there is great diversity between the CRISPR-Cas systems identified in L. johnsonii strains. Such diverse CRISPR-Cas systems indicate that these systems are naturally active and important in terms of adaptive immunity and evolutionary relationships.PMID:37703922 | DOI:10.1016/j.meegid.2023.105500
Source: Infection, Genetics and Evolution - September 13, 2023 Category: Genetics & Stem Cells Authors: Yousef Nami Mohaddeseh Rostampour Bahman Panahi Source Type: research
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases
Regen Med. 2023 Sep 13. doi: 10.2217/rme-2023-0089. Online ahead of print.ABSTRACTResearch has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential the...
Source: Regenerative Medicine - September 13, 2023 Category: Genetics & Stem Cells Authors: Wesley Harrisson Bouche Djatche Huimin Zhu Wenlei Ma Yue Li Ziang Li Hong Zhao Zhizhen Liu Hua Qiao Source Type: research
Upregulation of the key biomarker kinesin family member 20A (KIF20A) is associated with the pulmonary artery hypertension
CONCLUSION: The level of KIF20A elevates during the progression of PAH, which suggestes it could be a potential diagnostic and therapeutic target for the PAH.PMID:37703933 | DOI:10.1016/j.ygeno.2023.110705
Source: Genomics - September 13, 2023 Category: Genetics & Stem Cells Authors: Linqing Li Qi Xue Minhao Zhang Zhanneng Yang Dong Wang Gaoliang Yan Yong Qiao Chengchun Tang Rui Zhang Source Type: research
New perspectives on the causes and consequences of male meiotic drive
Curr Opin Genet Dev. 2023 Sep 11:102111. doi: 10.1016/j.gde.2023.102111. Online ahead of print.ABSTRACTGametogenesis is vulnerable to selfish genetic elements that bias their transmission to the next generation by cheating meiosis. These so-called meiotic drivers are widespread in plants, animals, and fungi and can impact genome evolution. Here, we summarize recent progress on the causes and consequences of meiotic drive in males, where selfish elements attack vulnerabilities in spermatogenesis. Advances in genomics provide new insights into the organization and dynamics of driving chromosomes in natural populations. Commo...
Source: Current Opinion in Genetics and Development - September 13, 2023 Category: Genetics & Stem Cells Authors: C écile Courret Xiaolu Wei Amanda M Larracuente Source Type: research
A new era of understanding in vivo metabolic flux in thermogenic adipocytes
Curr Opin Genet Dev. 2023 Sep 11;83:102112. doi: 10.1016/j.gde.2023.102112. Online ahead of print.ABSTRACTNonshivering thermogenesis by brown adipose tissue (BAT) is an adaptive mechanism for maintaining body temperature in cold environments. BAT is critical in rodents and human infants and has substantial influence on adult human metabolism. Stimulating BAT therapeutically is also being investigated as a strategy against metabolic diseases because of its ability to function as a catabolic sink. Thus, understanding how brown adipocytes and the related brite/beige adipocytes use nutrients to fuel their demanding metabolism ...
Source: Current Opinion in Genetics and Development - September 13, 2023 Category: Genetics & Stem Cells Authors: John A Haley Cholsoon Jang David A Guertin Source Type: research
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases
Regen Med. 2023 Sep 13. doi: 10.2217/rme-2023-0089. Online ahead of print.ABSTRACTResearch has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential the...
Source: Regenerative Medicine - September 13, 2023 Category: Genetics & Stem Cells Authors: Wesley Harrisson Bouche Djatche Huimin Zhu Wenlei Ma Yue Li Ziang Li Hong Zhao Zhizhen Liu Hua Qiao Source Type: research
Rational design of eukaryotic riboswitches that upregulate IRES-mediated translation initiation with high switching efficiency through a kinetic trapping mechanism < em > in vitro < /em >
RNA. 2023 Sep 13:rna.079778.123. doi: 10.1261/rna.079778.123. Online ahead of print.ABSTRACTIn general, riboswitches functioning through a co-transcriptional kinetic trapping mechanism (kt-riboswitches) show higher switching efficiencies in response to practical concentrations of their ligand molecules than eq-riboswitches, which function by an equilibrium mechanism. However, the former have been much more difficult to design due to their more complex mechanism. We here successfully developed a rational strategy for constructing eukaryotic kt-riboswitches that ligand-dependently enhance translation initiation mediated by a...
Source: RNA - September 13, 2023 Category: Genetics & Stem Cells Authors: Hajime Takahashi Masahiro Fujikawa Atsushi Ogawa Source Type: research
The Heritability of Psychopathology Symptoms in Early Adolescence: Moderation by Family Cultural Values in the ABCD Study
This study examined phenotypic associations between parent- and youth-reported family cultural values in late childhood on youth internalizing and externalizing symptoms in early adolescence, and whether family cultural values moderated genetic and environmental influences on psychopathology symptoms. The sample comprised 10,335 children (Mage=12.89 years; 47.9% female; 20.3% Hispanic/Latino/a, 15.0% Black, 2.1% Asian, 10.5% other) and their parents from the Adolescent Brain Cognitive Development (ABCD) Study, and biometric models were conducted in the twin subsample (n = 1,042 twin pairs; 43.3% monozygotic). Parents and y...
Source: Behavior Genetics - September 13, 2023 Category: Genetics & Stem Cells Authors: Gianna Rea-Sandin Juan Del Toro Sylia Wilson Source Type: research
Rational design of eukaryotic riboswitches that upregulate IRES-mediated translation initiation with high switching efficiency through a kinetic trapping mechanism < em > in vitro < /em >
RNA. 2023 Sep 13:rna.079778.123. doi: 10.1261/rna.079778.123. Online ahead of print.ABSTRACTIn general, riboswitches functioning through a co-transcriptional kinetic trapping mechanism (kt-riboswitches) show higher switching efficiencies in response to practical concentrations of their ligand molecules than eq-riboswitches, which function by an equilibrium mechanism. However, the former have been much more difficult to design due to their more complex mechanism. We here successfully developed a rational strategy for constructing eukaryotic kt-riboswitches that ligand-dependently enhance translation initiation mediated by a...
Source: RNA - September 13, 2023 Category: Genetics & Stem Cells Authors: Hajime Takahashi Masahiro Fujikawa Atsushi Ogawa Source Type: research
Innovative Genoceuticals in Human Gene Therapy Solutions: Challenges and Safe Clinical Trials of Orphan Gene Therapy Products
Curr Gene Ther. 2023 Sep 11. doi: 10.2174/1566523223666230911120922. Online ahead of print.ABSTRACTThe success of gene therapy attempts is controversial and inconclusive. Currently, it is popular among the public, the scientific community, and manufacturers of Gene Therapy Medical Products. In the absence of any remedy or treatment options available for untreatable inborn metabolic orphan or genetic diseases, cancer, or brain diseases, gene therapy treatment by genoceuticals and T-cells for gene editing and recovery remains the preferred choice as the last hope. A new concept of "Genoceutical Gene Therapy" by using orphan ...
Source: Current Gene Therapy - September 13, 2023 Category: Genetics & Stem Cells Authors: Rakesh Sharma Source Type: research
New perspectives on the causes and consequences of male meiotic drive
Curr Opin Genet Dev. 2023 Sep 11:102111. doi: 10.1016/j.gde.2023.102111. Online ahead of print.ABSTRACTGametogenesis is vulnerable to selfish genetic elements that bias their transmission to the next generation by cheating meiosis. These so-called meiotic drivers are widespread in plants, animals, and fungi and can impact genome evolution. Here, we summarize recent progress on the causes and consequences of meiotic drive in males, where selfish elements attack vulnerabilities in spermatogenesis. Advances in genomics provide new insights into the organization and dynamics of driving chromosomes in natural populations. Commo...
Source: Current Opinion in Genetics and Development - September 13, 2023 Category: Genetics & Stem Cells Authors: C écile Courret Xiaolu Wei Amanda M Larracuente Source Type: research
A new era of understanding in vivo metabolic flux in thermogenic adipocytes
Curr Opin Genet Dev. 2023 Sep 11;83:102112. doi: 10.1016/j.gde.2023.102112. Online ahead of print.ABSTRACTNonshivering thermogenesis by brown adipose tissue (BAT) is an adaptive mechanism for maintaining body temperature in cold environments. BAT is critical in rodents and human infants and has substantial influence on adult human metabolism. Stimulating BAT therapeutically is also being investigated as a strategy against metabolic diseases because of its ability to function as a catabolic sink. Thus, understanding how brown adipocytes and the related brite/beige adipocytes use nutrients to fuel their demanding metabolism ...
Source: Current Opinion in Genetics and Development - September 13, 2023 Category: Genetics & Stem Cells Authors: John A Haley Cholsoon Jang David A Guertin Source Type: research
