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Specialty: Genetics & Stem Cells
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Total 47651 results found since Jan 2013.
Biological properties of (1-4)-thio disaccharides
Carbohydr Res. 2023 Aug 31;533:108934. doi: 10.1016/j.carres.2023.108934. Online ahead of print.ABSTRACTThio sugars are carbohydrate derivatives in which one or more oxygen atoms have been replaced with sulfur. Thio sugars are effective inhibitors of glycosylases, have considerable therapeutic potential, and are used as drugs in the treatment of diabetes and infectious diseases. The development of this branch of carbohydrate chemistry would not be possible without the development of novel methods for its synthesis and the analysis of their biochemical properties. In this Review Article, we summarize our findings on the bio...
Source: Carbohydrate Research - September 14, 2023 Category: Genetics & Stem Cells Authors: Anna Czubatka-Bie ńkowska Joanna Sarnik Tomasz Poplawski Source Type: research
Detailed investigation and influence of oxidation degree on synthesis, characterization and antibacterial activity of β- cyclodextrin
Carbohydr Res. 2023 Sep 9;533:108936. doi: 10.1016/j.carres.2023.108936. Online ahead of print.ABSTRACTOxidation of β-cyclodextrin (β-CD) using varying molar ratios of sodium periodate (NaIO4) was investigated in detail on synthesis, characterization and antibacterial property. Synthesis and characterization results showed that Oxidized β-cyclodextrins (OX-β-CDs) were obtained and aldehyde (CHO) groups were successfully introduced. Our results demonstrated that aldehyde content and yield increased with increasing NaIO4 molar amount. However, the structure of β-CD was degraded as a result of glycosidic ring opening wit...
Source: Carbohydrate Research - September 14, 2023 Category: Genetics & Stem Cells Authors: Ayhan Bergal Muberra Andac Source Type: research
High TGM1 Allelic Heterogeneity causing Lamellar ichthyosis in a small geographic area in South Mexico: Another Example of the "R éunion Paradox"
Eur J Med Genet. 2023 Sep 12:104842. doi: 10.1016/j.ejmg.2023.104842. Online ahead of print.ABSTRACTLamellar ichthyosis (LI) is an autosomal recessive congenital ichthyosis characterized by generalized dry skin and severe scaling. It is caused by biallelic mutations in the TGM1 gene, however molecular data from non-Caucasian populations are limited. Results of genetic-molecular analysis of a group of LI pedigrees originating from two close small populations from south Mexico are presented. LI affected individuals belonging to 9 apparently unrelated families were studied. Exome sequencing or Sanger sequencing in probands fr...
Source: European Journal of Medical Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: O F Chacon-Camacho M C Astiazar án G Vera-Duarte H Guti érrez-Múgica N Macriz-Romero E O Graue-Hernandez J C Zenteno Source Type: research
The role of a multidisciplinary team in managing variants of uncertain clinical significance in prenatal genetic diagnosis
CONCLUSION: In this study three out of nine VUS could be re-classified as likely pathogenic after clinical follow-up. In order to protect pregnant couples from the burden of uncertain results, the genetic professionals have to take the responsibility to limit the reporting of VUS. This can be done not only by automated filtering of data, by following professional guidelines and by building standardized decision flows, but also by discussing individual cases considering personal situations and the involved disease and by sharing professional experience and responsibility in a multidisciplinary prenatal team setting.PMID:377...
Source: European Journal of Medical Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Karin E M Diderich Jasmijn E Klapwijk Vyne van der Schoot Myrthe van den Born Martina Wilke Marieke Joosten Kyra E Stuurman Lies H Hoefsloot Diane Van Opstal Hennie T Br üggenwirth Malgorzata I Srebniak Source Type: research
Analysis of polygenic selection in purebred and crossbred pig genomes using generation proxy selection mapping
CONCLUSIONS: This work confirms the efficacy and the negligible error rates of the GPSM method in detecting selected loci in commercial pig populations. Our results suggest shared selection objectives and genetic architectures across swine populations. The identified polygenic selection highlights loci that are important to swine production.PMID:37710159 | PMC:PMC10500877 | DOI:10.1186/s12711-023-00836-9
Source: Genet Sel Evol - September 14, 2023 Category: Genetics & Stem Cells Authors: Caleb J Grohmann Caleb M Shull Tamar E Crum Clint Schwab Timothy J Safranski Jared E Decker Source Type: research
Balance-Based Exercise Programs on Balance in Older Adults with Mild to Moderate Dementia: A Critically Appraised Topic
CONCLUSIONS: There is sufficient evidence to suggest that the use of physical therapy programs that include balance-based exercises, performed 1-2 times a week over the course of 12-25 weeks, improves balance in elderly adults with mild to moderate dementia.PMID:37709056 | DOI:10.1016/j.arr.2023.102073
Source: Ageing Research Reviews - September 14, 2023 Category: Genetics & Stem Cells Authors: Ella R Lenox Michael W Jones Source Type: research
Advancements in Computer-Assisted Diagnosis of Alzheimer's Disease: A Comprehensive Survey of Neuroimaging Methods and AI Techniques for Early Detection
This study lies in its comprehensive exploration of AD detection methods using a range of artificial intelligence (AI) techniques and neuroimaging modalities. By collecting and analysing 50 papers related to AD diagnosis datasets, the study provides a comprehensive understanding of the diversity of input types, subjects, and classes used in AD research. Summarizing 60 papers on methodologies gives researchers a succinct overview of various approaches that contribute to enhancing detection accuracy. From the review, data are acquired and pre-processed form multiple modalities of neuroimaging. This paper mainly focused on re...
Source: Ageing Research Reviews - September 14, 2023 Category: Genetics & Stem Cells Authors: Kogilavani Shanmugavadivel Sathishkumar V E Jaehyuk Cho Malliga Subramanian Source Type: research
Hormesis Defines The Limits Of Lifespan
Ageing Res Rev. 2023 Sep 12:102074. doi: 10.1016/j.arr.2023.102074. Online ahead of print.ABSTRACTThis commentary provides a novel synthesis of how biological systems adapt to a broad spectrum of environmental and age-related stresses that are underlying causes of numerous degenerative diseases and debilitating effects of aging. It proposes that the most fundamental, evolutionary-based integrative strategy to sustain and protect health is based on the concept of hormesis. This concept integrates anti-oxidant, anti-inflammatory and cellular repair responses at all levels of biological organization (i.e., cell, organ and org...
Source: Ageing Research Reviews - September 14, 2023 Category: Genetics & Stem Cells Authors: Edward J Calabrese Naomi Osakabe Rosanna Di Paola Rosalba Siracusa Roberta Fusco Ramona D'Amico Daniela Impellizzeri Salvatore Cuzzocrea Tilman Fritsch Ali S Abdelhameed Uwe Wenzel Claudio Franceschi V Calabrese Source Type: research
Genome-wide identification of nitrate transporter 1/peptide transporter (NPFs) family genes reveals that PaNPF5.5 enhances nitrate uptake under high nitrate condition in sweet cherry
In this study, a total of 60 PaNPF genes in sweet cherry were identified by bioinformatics, which were divided into 8 families. Transcriptomic analysis showed that most PaNPF genes responded to both low and high nitrate conditions, especially PaNPF5.5, which was highly up-regulated under high nitrate condition. Molecular analysis showed that PaNPF5.5 was a transporter localized to the cell membrane. Further functional studies found that PaNPF5.5 overexpression promoted the growth of sweet cherry rootstock Gisela 6 by accelerating the nitrogen absorption process under high nitrate environment. Taken together, we believe tha...
Source: Gene - September 14, 2023 Category: Genetics & Stem Cells Authors: Jingtao Wang Lei Wang Xu Zhang Songlin Li Xiaohui Wang Lina Yang Fanlin Wu Hongyan Su Source Type: research
Anticancer Effects of Cell-Free Culture Supernatant of Escherichia coli in Bladder Cancer Cell Line: New Insight into the Regulation of Inflammation
In conclusion, our findings demonstrate that this compound is a potential candidate for the suppression of bladder cancer progression.PMID:37708921 | DOI:10.1016/j.gene.2023.147795
Source: Gene - September 14, 2023 Category: Genetics & Stem Cells Authors: Amirreza Mehmandar-Oskuie Masoud Tohidfar Bahareh Hajikhani Forouzan Karimi Source Type: research
Centromere: A Trojan horse for genome stability
DNA Repair (Amst). 2023 Sep 7;130:103569. doi: 10.1016/j.dnarep.2023.103569. Online ahead of print.ABSTRACTCentromeres play a key role in the maintenance of genome stability to prevent carcinogenesis and diseases. They are specialized chromosome loci essential to ensure faithful transmission of genomic information across cell generations by mediating the interaction with spindle microtubules. Nonetheless, while fulfilling these essential roles, their distinct repetitive composition and susceptibility to mechanical stresses during cell division render them susceptible to breakage events. In this review, we delve into the pr...
Source: DNA Repair - September 14, 2023 Category: Genetics & Stem Cells Authors: Andrea Scelfo Daniele Fachinetti Source Type: research
Prospects and challenges of CRISPR/Cas9 gene-editing technology in cancer research
Clin Genet. 2023 Sep 14. doi: 10.1111/cge.14424. Online ahead of print.ABSTRACTCancer, one of the leading causes of death, usually commences and progresses as a result of a series of gene mutations and dysregulation of expression. With the development of clustered regularly interspaced palindromic repeat (CRISPR)/Cas9 gene-editing technology, it is possible to edit and then decode the functions of cancer-related gene mutations, markedly advance the research of biological mechanisms and treatment of cancer. This review summarizes the mechanism and development of CRISPR/Cas9 gene-editing technology in recent years and descri...
Source: Clinical Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Li Ning Jiahui Xi Yin Zi Min Chen Qingjian Zou Xiaoqing Zhou Chengcheng Tang Source Type: research
C. C. Li and Quasi-Random Mating
Twin Res Hum Genet. 2023 Sep 14:1-3. doi: 10.1017/thg.2023.37. Online ahead of print.ABSTRACTA simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies is stated and illustrated. The title 'Quasi-random mating' is proposed. Confusion about the Hardy-Weinberg principle can be avoided only if there is clear separation between the basic deterministic model and factors influencing a population's structure. Eighty years passed before C. C. Li coined the term 'pseudo-random mating'. The lesson taught by Li has not been taken on board.PMID:37706311 | DOI:10.1017/thg.2023.37
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Alan E Stark Source Type: research
A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome
Twin Res Hum Genet. 2023 Sep 14:1-7. doi: 10.1017/thg.2023.38. Online ahead of print.ABSTRACTFetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was perfor...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Silvia Vannuccini Sara Bolzonella Chiara Colucci Costanza Nicchi Noemi Strambi Mariarosaria Di Tommaso Source Type: research
Engineering of insecticidal hybrid gene into potato chloroplast genome exhibits promising control of Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)
Transgenic Res. 2023 Sep 14. doi: 10.1007/s11248-023-00366-6. Online ahead of print.ABSTRACTThe potato chloroplast was transformed with codon optimized synthetic hybrid cry gene (SN19) to mitigate crop losses by Colorado potato beetle (CPB). The bombarded explants (leaves and internode) were cultured on MS medium supplemented with BAP (2.0 mg/l), NAA (0.2 mg/l), TDZ (2.0 mg/l) and GA3 (0.1 mg/l); spectinomycin 50 mg/l was used as a selection agent in the medium. Leaf explants of cultivar Kuroda induced highest percentage (92%) of callus where cultivar Santae produced the highest percentage (85.7%) of transplastomic shoots....
Source: Transgenic Research - September 14, 2023 Category: Genetics & Stem Cells Authors: Md Jakir Hossain Allah Bakhsh Faiz Ahmad Joyia Emre Aksoy Neslihan Zahide Özturk Gökçe Muhammad Sarwar Khan Source Type: research
