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Neuronal AR regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess
Endocrinology. 2023 Sep 21:bqad141. doi: 10.1210/endocr/bqad141. Online ahead of print.ABSTRACTHyperandrogenemia and polycystic ovarian syndrome are a result of the imbalance of androgen levels in females. Androgen receptor (Ar) mediates the effect of androgen, and this study examines how neuronal Ar in the central nervous system (CNS) mediates metabolism under normal and increased androgen conditions in female mice. The neuron specific ARKO mouse (SynARKO) was created from female (Ar fl/wt; synapsin promoter driven Cre) and male (Ar fl/y) mice. Glucose tolerance test revealed impaired glucose tolerance that was partially ...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Vaibhave Ubba Serene Joseph Olubusayo Awe Dustin Jones Milan K Dsilva Mingxiao Feng Junjiang Wang Xiaomin Fu Razeen J Akbar Brittany H Bodnar Wenhui Hu Hong Wang Xiaofeng Yang Ling Yang Peixin Yang Rexford Ahima Sara Divall Sheng Wu Source Type: research
Significant Changes in Resting Metabolic Rate Over a Competitive Match Week Are Accompanied by an Absence of Nutritional Periodization in Male Professional Soccer Players
We report, for the first time, that RMR is significantly increased following a competitive match in professional soccer players. In addition, we confirm previous findings to reinforce that players exhibit inadequate nutrition periodization practices, which may impair physical performance and recovery.PMID:37734739 | DOI:10.1123/ijsnem.2023-0069
Source: International Journal of Sport Nutrition and Exercise Metabolism - September 21, 2023 Category: Sports Medicine Authors: Jennie L Carter David J Lee Craig G Perrin Mayur K Ranchordas Matthew Cole Source Type: research
High levels of uric acid inhibit BAT thermogenic capacity through regulation of AMPK
Am J Physiol Endocrinol Metab. 2023 Sep 21. doi: 10.1152/ajpendo.00092.2023. Online ahead of print.ABSTRACTHyperuricemia (HUA) is strongly associated with the increasing prevalence of obesity, but the underlying mechanism remains elusive. Dysfunction of brown adipose tissue (BAT) could lead to obesity. However, studies on the role of HUA on BAT are lacking. Our retrospective clinical analysis showed that serum uric acid (UA) is significantly associated with BAT in humans. To investigate the role of UA in regulating BAT function, we used UA to treat primary brown adipocytes (BAC) in vitro and established HUA mice. In vitro ...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 21, 2023 Category: Physiology Authors: Meijuan Dong Kun An Li Mao Source Type: research
Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice
J Lipid Res. 2023 Sep 19:100449. doi: 10.1016/j.jlr.2023.100449. Online ahead of print.ABSTRACTActivation of brown adipose tissue (BAT) contributes to energy dissipation and metabolic health. Although mineralocorticoid receptor (MR) antagonists have been demonstrated to improve metabolism under obesity, the underlying mechanisms remain incompletely understood. We aimed to evaluate the role of BAT MR in metabolic regulation. After 8 weeks of high fat diet (HFD) feeding, BAT MR knockout (BMRKO) mice manifested significantly increased body weight, fat mass, serum fasting glucose and impaired glucose homeostasis compared to li...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Chu-Mao Chen Xiao-Qian Meng Hong Zhu Ting Liu Yuan Liu Lu-Jun Zhou Guo-Dong Zhu Xiao-Bei Chen Xu-Guang Guo Sheng-Zhong Duan Source Type: research
High levels of uric acid inhibit BAT thermogenic capacity through regulation of AMPK
Am J Physiol Endocrinol Metab. 2023 Sep 21. doi: 10.1152/ajpendo.00092.2023. Online ahead of print.ABSTRACTHyperuricemia (HUA) is strongly associated with the increasing prevalence of obesity, but the underlying mechanism remains elusive. Dysfunction of brown adipose tissue (BAT) could lead to obesity. However, studies on the role of HUA on BAT are lacking. Our retrospective clinical analysis showed that serum uric acid (UA) is significantly associated with BAT in humans. To investigate the role of UA in regulating BAT function, we used UA to treat primary brown adipocytes (BAC) in vitro and established HUA mice. In vitro ...
Source: Am J Physiol Endocri... - September 21, 2023 Category: Endocrinology Authors: Meijuan Dong Kun An Li Mao Source Type: research
Greater male variability in daily energy expenditure develops through puberty
Biol Lett. 2023 Sep;19(9):20230152. doi: 10.1098/rsbl.2023.0152. Epub 2023 Sep 20.ABSTRACTThere is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing ...
Source: Biology Letters - September 20, 2023 Category: Biology Authors: Lewis G Halsey Vincent Careau Philip N Ainslie Heliodoro Alem án-Mateo Lene F Andersen Liam J Anderson Leonore Arab Issad Baddou Linda Bandini Kweku Bedu-Addo Ellen E Blaak Stephane Blanc Alberto G Bonomi Carlijn V C Bouten Pascal Bovet Soren Brage Macie Source Type: research
Association between total available nutritional quality and food expenditure in Peruvian households, 2019-2020
Cad Saude Publica. 2023 Sep 18;39(9):e00021923. doi: 10.1590/0102-311XEN021923. eCollection 2023.ABSTRACTEvidence points to a direct relationship between nutritional quality and food expenditure. However, food expenditure is highly susceptible to changes, and nutritional quality of household food presents limited evidence. The aim of this study was to assess the relationship between nutritional quality available and total food expenditure in Peruvian households, and whether there were differences by area (urban and rural) and between years of the COVID-19 pandemic. For this, we used Peru's National Household Survey (ENAHO)...
Source: Cadernos de Saude Publica - September 20, 2023 Category: International Medicine & Public Health Authors: Karen Bonilla-Aguilar Antonio Bernabe-Ortiz Source Type: research
Greater male variability in daily energy expenditure develops through puberty
Biol Lett. 2023 Sep;19(9):20230152. doi: 10.1098/rsbl.2023.0152. Epub 2023 Sep 20.ABSTRACTThere is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing ...
Source: Biology Letters - September 20, 2023 Category: Biology Authors: Lewis G Halsey Vincent Careau Philip N Ainslie Heliodoro Alem án-Mateo Lene F Andersen Liam J Anderson Leonore Arab Issad Baddou Linda Bandini Kweku Bedu-Addo Ellen E Blaak Stephane Blanc Alberto G Bonomi Carlijn V C Bouten Pascal Bovet Soren Brage Macie Source Type: research
The heterogeneity of metabolic syndrome presentation and challenges this causes in its pharmacological management. A narrative review focusing on principal risk modifiers
Expert Rev Clin Pharmacol. 2023 Sep 18. doi: 10.1080/17512433.2023.2259306. Online ahead of print.ABSTRACTINTRODUCTION: Metabolic syndrome (MetS), i.e. the cluster of cardiometabolic risk factors comprising visceral obesity, impaired glucose metabolism, arterial hypertension and atherogenic dyslipidemia, is prevalent globally and exacts a heavy toll on health care expenditures.AREAS COVERED: The pathophenotypes of individual traits of the MetS in adults are discussed first, with strong emphasis on nonalcoholic fatty liver disease (NAFLD) and sex differences. Next, I discuss recent studies on phenotypic and outcome heteroge...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Amedeo Lonardo Source Type: research
Analysis of critical peak electricity price optimization model considering coal consumption rate of power generation side
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29754-5. Online ahead of print.ABSTRACTAs a flexible electricity pricing mechanism, critical peak pricing (CPP) is one of the important means of demand response under the electricity market. The existing CPP research does not take into account the carbon emission problem of units and weakens the difference between the use of terminal loads on critical peak days and non-critical peak days in the establishment of electricity price model, so this paper studies the feedback mechanism of CPP on coal consumption of power generation side units and proposes a dynamic...
Source: Environmental Science and Pollution Research International - September 18, 2023 Category: Environmental Health Authors: Xiaobao Yu Zhenyu Dong Dandan Zheng Siwei Deng Source Type: research
Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 18. doi: 10.1152/ajpregu.00137.2023. Online ahead of print.ABSTRACTPostnatal growth failure remains a significant problem for infants born prematurely, despite aggressive efforts to improve perinatal nutrition. Though often dysregulated in early life when children are born preterm, sodium (Na) homeostasis is vital to achieve optimal growth. We hypothesize that insufficient Na supply in this critical period contributes to growth restriction and programmed risks for cardiometabolic disease in later adulthood. Thus, we sought to ascertain the effects of prolonged versus early-l...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Alisha A Ziegler Samuel B R Lawton Connie C Grobe John J Reho Bonnie P Freudinger Colin M L Burnett Pablo Nakagawa Justin L Grobe Jeffrey L Segar Source Type: research
The heterogeneity of metabolic syndrome presentation and challenges this causes in its pharmacological management. A narrative review focusing on principal risk modifiers
Expert Rev Clin Pharmacol. 2023 Sep 18. doi: 10.1080/17512433.2023.2259306. Online ahead of print.ABSTRACTINTRODUCTION: Metabolic syndrome (MetS), i.e. the cluster of cardiometabolic risk factors comprising visceral obesity, impaired glucose metabolism, arterial hypertension and atherogenic dyslipidemia, is prevalent globally and exacts a heavy toll on health care expenditures.AREAS COVERED: The pathophenotypes of individual traits of the MetS in adults are discussed first, with strong emphasis on nonalcoholic fatty liver disease (NAFLD) and sex differences. Next, I discuss recent studies on phenotypic and outcome heteroge...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Amedeo Lonardo Source Type: research
Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 18. doi: 10.1152/ajpregu.00137.2023. Online ahead of print.ABSTRACTPostnatal growth failure remains a significant problem for infants born prematurely, despite aggressive efforts to improve perinatal nutrition. Though often dysregulated in early life when children are born preterm, sodium (Na) homeostasis is vital to achieve optimal growth. We hypothesize that insufficient Na supply in this critical period contributes to growth restriction and programmed risks for cardiometabolic disease in later adulthood. Thus, we sought to ascertain the effects of prolonged versus early-l...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Alisha A Ziegler Samuel B R Lawton Connie C Grobe John J Reho Bonnie P Freudinger Colin M L Burnett Pablo Nakagawa Justin L Grobe Jeffrey L Segar Source Type: research
Analysis of critical peak electricity price optimization model considering coal consumption rate of power generation side
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29754-5. Online ahead of print.ABSTRACTAs a flexible electricity pricing mechanism, critical peak pricing (CPP) is one of the important means of demand response under the electricity market. The existing CPP research does not take into account the carbon emission problem of units and weakens the difference between the use of terminal loads on critical peak days and non-critical peak days in the establishment of electricity price model, so this paper studies the feedback mechanism of CPP on coal consumption of power generation side units and proposes a dynamic...
Source: Environmental Science and Pollution Research International - September 18, 2023 Category: Environmental Health Authors: Xiaobao Yu Zhenyu Dong Dandan Zheng Siwei Deng Source Type: research
