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Infectious Disease: Herpes

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Total 11557 results found since Jan 2013.

Herpes Simplex Virus Type 1 Infection Induces the Formation of Tunneling Nanotubes
Microorganisms. 2023 Jul 28;11(8):1916. doi: 10.3390/microorganisms11081916.ABSTRACTHerpes simplex virus type 1 (HSV-1) is human specific virus. The intercellular transmission of HSV-1 is essential in its pathogenesis. The tunneling nanotube (TNT), a new mode connecting distant cells, has been found to play an important role in the spread of various viruses like human immunodeficiency virus (HIV) and influenza virus. However, whether HSV-1 can be transmitted through TNTs has not been confirmed. The purpose of this study was to clarify this, and further to determine the effect of inhibiting the actin-related protein 2/3 (Ar...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Jie Wang Kun-Te Shang Qiong-Hong Ma Zhao-Ying Dong Yi-Hong Chen Yu-Feng Yao Source Type: research

Instantaneous Inactivation of Herpes Simplex Virus by Silicon Nitride Bioceramics
Int J Mol Sci. 2023 Aug 10;24(16):12657. doi: 10.3390/ijms241612657.ABSTRACTHydrolytic reactions taking place at the surface of a silicon nitride (Si3N4) bioceramic were found to induce instantaneous inactivation of Human herpesvirus 1 (HHV-1, also known as Herpes simplex virus 1 or HSV-1). Si3N4 is a non-oxide ceramic compound with strong antibacterial and antiviral properties that has been proven safe for human cells. HSV-1 is a double-stranded DNA virus that infects a variety of host tissues through a lytic and latent cycle. Real-time reverse transcription (RT)-polymerase chain reaction (PCR) tests of HSV-1 DNA after in...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Giuseppe Pezzotti Eriko Ohgitani Saki Ikegami Masaharu Shin-Ya Tetsuya Adachi Toshiro Yamamoto Narisato Kanamura Elia Marin Wenliang Zhu Kazu Okuma Osam Mazda Source Type: research

Multiple Administration Routes, Including Intramuscular Injection, of Oncolytic Tanapoxvirus Variants Significantly Regress Human Melanoma Xenografts in BALB/c Nude Mice Reconstituted with Splenocytes from Normal BALB/c Donors
In this study, TPV/Δ66R/mIL-2 and TPV/Δ2L/Δ66R/FliC were tested for their ability to treat human melanoma xenografts (SK-MEL3) in a BALB/c nude mouse model reconstituted with splenocytes from genetically compatible, normal BALB/c donor mice. Two SK-MEL3 tumors were transplanted into each flank of BALB/c nude mice, and the larger tumor was treated intratumorally (IT) with virus or mock injection. In one set of animals, mice received adoptive transfers of splenocytes from BALB/c mice on day 4 to reconstitute their immune systems and allow for adaptive immune responses to occur in a xenograft model. Direct IT injection of ...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Michael L Monaco Omer A Idris Grace A Filpi Steven L Kohler Scott D Haller Jeffery E Burr Robert Eversole Karim Essani Source Type: research

Molecular Characterization of UL50 (dUTPase) Gene of Bovine Herpes Virus 1
In this study, we analyzed the amino acid sequence of UL50 (dUTPase) using bioinformatics tools and found that it was highly conserved among herpesvirus family. Then, it was cloned and expressed in Escherichia coli Rosetta (DE3), induced by isopropy1-b-D-thiogalactopyranoside (IPTG) and the recombinant UL50 protein was purified to immunize rabbits for the preparation of polyclonal antiserum. The results indicated that the UL50 gene of BoHV-1 was composed of 978 nucleotides, which encoded 323 amino acids. Western blot analysis revealed that polyclonal sera against UL50 reacted with a band of 34 kDa. Furthermore, immunofluor...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Farzana Shahin Sohail Raza Xi Chen Changmin Hu Yingyu Chen Huanchun Chen Aizhen Guo Source Type: research

Efficacy of Systemically Administered Retargeted Oncolytic Herpes Simplex Viruses-Clearance and Biodistribution in Na ïve and HSV-Preimmune Mice
Cancers (Basel). 2023 Aug 10;15(16):4042. doi: 10.3390/cancers15164042.ABSTRACTWe investigated the anticancer efficacy, blood clearance, and tissue biodistribution of systemically administered retargeted oncolytic herpes simplex viruses (ReHVs) in HSV-naïve and HSV-preimmunized (HSV-IMM) mice. Efficacy was tested against lung tumors formed upon intravenous administration of cancer cells, a model of metastatic disease, and against subcutaneous distant tumors. In naïve mice, HER2- and hPSMA-retargeted viruses, both armed with mIL-12, were highly effective, even when administered to mice with well-developed tumors. Efficacy...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Andrea Vannini Federico Parenti Catia Barboni Cristina Forghieri Valerio Leoni Mara Sanapo Daniela Bressanin Anna Zaghini Gabriella Campadelli-Fiume Tatiana Gianni Source Type: research

Dermatological Issues Among Individuals Receiving Palliative Care - A Review
Am J Hosp Palliat Care. 2023 Aug 25:10499091231198752. doi: 10.1177/10499091231198752. Online ahead of print.ABSTRACTSkin disorders among individuals receiving palliative care may be associated with the primary condition or underlying comorbidities and patients may experience pruritus, discomfort or pain. Common conditions include xerosis, pressure ulcers, intertrigo, superficial fungal infections, telogen effluvium, pruritus, herpes zoster, eczematous disorders and edema. During end-of-life care, there is reduced skin perfusion and metabolism hence leading to susceptibility to infection, pressure and injury. Other factors...
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Zhenli Kwan Winn Hui Han Shin Shen Yong Nik Aimee Azizah Faheem Rebecca Kai Jan Choong Sheriza Izwa Zainuddin Chee Loong Lam Maw Pin Tan David Paul Capelle Source Type: research

Lactobacillus rhamnosus GG Regulates Host IFN-I Through the RIG-I Signalling Pathway to Inhibit Herpes Simplex Virus Type 2 Infection
Probiotics Antimicrob Proteins. 2023 Aug 25. doi: 10.1007/s12602-023-10137-8. Online ahead of print.ABSTRACTNumerous recent studies have demonstrated that the commensal microbiota plays an important role in host immunity against infections. During the infection process, viruses can exhibit substantial and close interactions with the commensal microbiota. However, the associated mechanism remains largely unknown. Therefore, in this study, we explored the specific mechanisms by which the commensal microbiota modulates host immunity against viral infections. We found that the expression levels of type I interferon (IFN-I) and...
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Jingyu Wang Mei Huang Yuqi Du Haoming Chen Zixiong Li Taiyu Zhai Zihao Ou Yiyi Huang Fan Bu Haojun Zhen Ruoru Pan Yubing Wang Xiaohan Zhao Bo Situ Lei Zheng Xiumei Hu Source Type: research

Detection of Human Herpesviruses in Sera and Saliva of Asymptomatic HIV-Infected Individuals Using Multiplex RT-PCR DNA Microarray
In conclusion, the multiplex RT-PCR DNA microarray can serve as a valuable diagnostic tool that can be used as a screening tool or a first-line test for HHVs infections.PMID:37623953 | DOI:10.3390/pathogens12080993
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Irna Sufiawati Rahmi Harmiyati Nanan Nur'aeny Agnes Rengga Indrati Ronny Lesmana Rudi Wisaksana Riezki Amalia Source Type: research

Prevalence, Risk factors, and Shedding of Human Herpes Virus-8 among Men Having Sex With Men Enrolled in a Pre-exposure Prophylaxis Study
CONCLUSION: Prevalence and incidence of HHV-8 infection were high in HIV-negative PrEP users. Among seropositive participants, HHV-8 DNA is mainly detected in saliva, which may play a major role in viral transmission in this population.PMID:37623814 | DOI:10.1093/cid/ciad502
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Julien Gras Marion Helary Diane Carette Marine Minier Maud Salmona Audrey Gabassi Marine Saouzanet Isabelle Charreau Laurence Meyer Jean-Michel Molina Constance Delaugerre Source Type: research

Acute hepatitis of unknown etiology in an adult female: A case report
CONCLUSION: Idiopathic hepatitis makes treatment challenging. It can leave patients feeling confused and unfulfilled. Thus, educating the patient thoroughly for shared decision-making and management becomes essential.PMID:37621598 | PMC:PMC10445075 | DOI:10.12998/wjcc.v11.i22.5288
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Lucinda Dass Alexandra Marie Malabanan Pacia Mahgol Hamidi Source Type: research

Dermatological Issues Among Individuals Receiving Palliative Care - A Review
Am J Hosp Palliat Care. 2023 Aug 25:10499091231198752. doi: 10.1177/10499091231198752. Online ahead of print.ABSTRACTSkin disorders among individuals receiving palliative care may be associated with the primary condition or underlying comorbidities and patients may experience pruritus, discomfort or pain. Common conditions include xerosis, pressure ulcers, intertrigo, superficial fungal infections, telogen effluvium, pruritus, herpes zoster, eczematous disorders and edema. During end-of-life care, there is reduced skin perfusion and metabolism hence leading to susceptibility to infection, pressure and injury. Other factors...
Source: The American Journal of Hospice and Palliative Care - August 25, 2023 Category: Palliative Care Authors: Zhenli Kwan Winn Hui Han Shin Shen Yong Nik Aimee Azizah Faheem Rebecca Kai Jan Choong Sheriza Izwa Zainuddin Chee Loong Lam Maw Pin Tan David Paul Capelle Source Type: research

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