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Infectious Disease: Herpes
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Total 11557 results found since Jan 2013.
Increased Risk of Infertility in Women Infected with Human Papillomavirus
CONCLUSION: Since HPV infection is asymptomatic, periodic screening of women in reproductive age especially infertile couples is recommended for early diagnosis and prevention of infection progression and cross contamination.PMID:37663425 | PMC:PMC10471950 | DOI:10.18502/jri.v24i3.13275
Source: Herpes - September 4, 2023 Category: Infectious Diseases Authors: Parastou Heidari Pebdeni Fereshteh Saffari Hamid Reza Mollaei Toraj Reza Mirshekari Robabeh Hosseini Sadat Victoria Habibzadeh Lida Saeed Moslem Taheri Soodejani Roya Ahmadrajabi Source Type: research
A real-world pharmacovigilance analysis of FDA adverse event reporting system database for upadacitinib
Conclusion: Clinicians should be vigilant to upadacitinib-induced events in systems not covered in the drug labeling information and to new and highly signaled ADEs to ensure the safe and effective use of upadacitinib.PMID:37663269 | PMC:PMC10469920 | DOI:10.3389/fphar.2023.1200254
Source: Herpes - September 4, 2023 Category: Infectious Diseases Authors: Yan Wu Meihao Wei Jing Zhang Source Type: research
Dupilumab strengthens HSV-1 specific immune responses in atopic dermatitis
CONCLUSION: Our findings suggest that dupilumab may improve the HSV-1-specific immune response in AD due to an increased type I immune response and a reduction of HSV-1-specific IgE.PMID:37660986 | DOI:10.1016/j.jaci.2023.08.024
Source: Herpes - September 3, 2023 Category: Infectious Diseases Authors: Stephan Traidl Leonard Harries Petra Kienlin Gabriele Begemann Lennart M Roesner Thomas Werfel Source Type: research
Safety, efficacy, and immunogenicity of a replication-defective human cytomegalovirus vaccine, V160, in cytomegalovirus-seronegative women: a double-blind, randomised, placebo-controlled, phase 2b trial
This study provides insights into the design of future CMV vaccine efficacy trials, particularly for the identification of CMV infection using molecular assays.FUNDING: Merck Sharp & Dohme, a subsidiary of Merck & Co, Rahway, NJ, USA (MSD).PMID:37660711 | DOI:10.1016/S1473-3099(23)00343-2
Source: Herpes - September 3, 2023 Category: Infectious Diseases Authors: Rituparna Das Daniel Bl ázquez-Gamero David I Bernstein Soren Gantt Oliver Bautista Karen Beck Anthony Conlon Daniel I S Rosenbloom Dai Wang Michael Ritter Beth Arnold Paula Annunziato Kevin L Russell V160-002 study group Source Type: research
Homeopathic Treatment of Ramsay Hunt Syndrome: A Case Report
CONCLUSION: This case report highlights an exceptional instance of RHS recovery within a relatively short timeframe, achieved through the administration of individualized homeopathic therapy. The favorable outcomes observed in this case underscore the potential of homeopathy as a promising alternative intervention for RHS management. Nevertheless, further systematic investigations are imperative to comprehensively evaluate the scope and applicability of homeopathy in the treatment of RHS.PMID:37660686 | DOI:10.1159/000533849
Source: Herpes - September 3, 2023 Category: Infectious Diseases Authors: Puja Bhakta Abhijit Dutta Source Type: research
In Vivo CRISPR Gene Editing in Patients with Herpes Stromal Keratitis
Mol Ther. 2023 Aug 31:S1525-0016(23)00487-2. doi: 10.1016/j.ymthe.2023.08.021. Online ahead of print.ABSTRACTIn vivo CRISPR gene therapy holds large clinical potential, but the safety and efficacy remain largely unknown. Here, we injected a single dose of HSV-1-targeting CRISPR formulation in the cornea of three patients with severe refractory herpes stromal keratitis (HSK) during corneal transplantation. Our study is an investigated initiated, open-label, single-arm, non-randomized interventional trial at a single center (NCT04560790). We found neither detectable CRISPR-induced off-target cleavages by GUIDE-seq nor system...
Source: Herpes - September 2, 2023 Category: Infectious Diseases Authors: Anji Wei Di Yin Zimeng Zhai Sikai Ling Huangying Le Lijia Tian Jianjiang Xu Soren R Paludan Yujia Cai Jiaxu Hong Source Type: research
Tofacitinib versus oral prednisolone for induction of remission in moderately active ulcerative colitis (ORCHID): A prospective, open-label, randomized, pilot study
CONCLUSION: In patients with moderately active ulcerative colitis, there was no difference in the efficacy and safety of tofacitinib and oral prednisolone for induction of remission at 8 weeks.PMID:37656880 | DOI:10.1093/ecco-jcc/jjad153
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Arshdeep Singh Vandana Midha Kirandeep Kaur Ramit Mahajan Dharmatma Singh Ramandeep Kaur Aditya Kohli Avantika Chawla Kriti Sood Namita Bansal Ajit Sood Source Type: research
Boosting of vaginal HSV-2-specific B and T cell responses by intravaginal therapeutic immunization results in diminished recurrent HSV-2 disease
In this study, a therapeutic vaccine given intravaginally resulted in significantly better protection against HSV-2 disease than immunization with the same vaccine by a conventional route. Immunization by the intravaginal route resulted in greater stimulation of vaginal-resident, virus-specific cells that produced antibody and produced immune molecules to rapidly clear virus.PMID:37655939 | DOI:10.1128/jvi.00669-23
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Nigel Bourne Celeste A Keith Aaron L Miller Richard B Pyles Gary Cohen Gregg N Milligan Source Type: research
Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons
In this study, we determined the effects of type I, II, and III IFNs on HSV-1 release from sensory axons. Using compartmentalized microfluidic devices separating axons from the neuronal cell bodies, we showed that treating axons with type I (IFNα and IFNβ), type II (IFNγ), and type III (IFNλ) IFNs inhibited the release of HSV-1 from axons, without altering the anterograde axonal transport of viral components. Furthermore, we showed that only type II IFN induced a cell-wide response following axonal treatment, with phosphorylated STAT1 and STAT3 present along axons and in the neuronal cell body, whereas type I and III I...
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Kevin Danastas Gerry Guo Jessica Merjane Nathan Hong Ava Larsen Monica Miranda-Saksena Anthony L Cunningham Source Type: research
The role of food allergy as a provoking factor of migraine
CONCLUSION: We show for the first time the relationship between delayed-type food allergy and redistribution in the microbiome of the oropharynx of patients with migraine and once again confirm the role of delayed-type food allergy as a clinically significant factor influencing the course of migraine (its intensity and chronicity).PMID:37655411 | DOI:10.17116/jnevro202312308156
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: I L Naidenova A B Danilov A V Simonova A A Pilipovich E G Filatova Source Type: research
Tofacitinib versus oral prednisolone for induction of remission in moderately active ulcerative colitis (ORCHID): A prospective, open-label, randomized, pilot study
CONCLUSION: In patients with moderately active ulcerative colitis, there was no difference in the efficacy and safety of tofacitinib and oral prednisolone for induction of remission at 8 weeks.PMID:37656880 | DOI:10.1093/ecco-jcc/jjad153
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Arshdeep Singh Vandana Midha Kirandeep Kaur Ramit Mahajan Dharmatma Singh Ramandeep Kaur Aditya Kohli Avantika Chawla Kriti Sood Namita Bansal Ajit Sood Source Type: research
Boosting of vaginal HSV-2-specific B and T cell responses by intravaginal therapeutic immunization results in diminished recurrent HSV-2 disease
In this study, a therapeutic vaccine given intravaginally resulted in significantly better protection against HSV-2 disease than immunization with the same vaccine by a conventional route. Immunization by the intravaginal route resulted in greater stimulation of vaginal-resident, virus-specific cells that produced antibody and produced immune molecules to rapidly clear virus.PMID:37655939 | DOI:10.1128/jvi.00669-23
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Nigel Bourne Celeste A Keith Aaron L Miller Richard B Pyles Gary Cohen Gregg N Milligan Source Type: research
Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons
In this study, we determined the effects of type I, II, and III IFNs on HSV-1 release from sensory axons. Using compartmentalized microfluidic devices separating axons from the neuronal cell bodies, we showed that treating axons with type I (IFNα and IFNβ), type II (IFNγ), and type III (IFNλ) IFNs inhibited the release of HSV-1 from axons, without altering the anterograde axonal transport of viral components. Furthermore, we showed that only type II IFN induced a cell-wide response following axonal treatment, with phosphorylated STAT1 and STAT3 present along axons and in the neuronal cell body, whereas type I and III I...
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Kevin Danastas Gerry Guo Jessica Merjane Nathan Hong Ava Larsen Monica Miranda-Saksena Anthony L Cunningham Source Type: research
The role of food allergy as a provoking factor of migraine
CONCLUSION: We show for the first time the relationship between delayed-type food allergy and redistribution in the microbiome of the oropharynx of patients with migraine and once again confirm the role of delayed-type food allergy as a clinically significant factor influencing the course of migraine (its intensity and chronicity).PMID:37655411 | DOI:10.17116/jnevro202312308156
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: I L Naidenova A B Danilov A V Simonova A A Pilipovich E G Filatova Source Type: research
