Filtered By:
Infectious Disease: Herpes
This page shows you your search results in order of date. This is page number 14.
Order by Relevance | Date
Total 11557 results found since Jan 2013.
Multiple Administration Routes, Including Intramuscular Injection, of Oncolytic Tanapoxvirus Variants Significantly Regress Human Melanoma Xenografts in BALB/c Nude Mice Reconstituted with Splenocytes from Normal BALB/c Donors
In this study, TPV/Δ66R/mIL-2 and TPV/Δ2L/Δ66R/FliC were tested for their ability to treat human melanoma xenografts (SK-MEL3) in a BALB/c nude mouse model reconstituted with splenocytes from genetically compatible, normal BALB/c donor mice. Two SK-MEL3 tumors were transplanted into each flank of BALB/c nude mice, and the larger tumor was treated intratumorally (IT) with virus or mock injection. In one set of animals, mice received adoptive transfers of splenocytes from BALB/c mice on day 4 to reconstitute their immune systems and allow for adaptive immune responses to occur in a xenograft model. Direct IT injection of ...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Michael L Monaco Omer A Idris Grace A Filpi Steven L Kohler Scott D Haller Jeffery E Burr Robert Eversole Karim Essani Source Type: research
Exploring missed opportunities for influenza vaccination and influenza vaccine co-administration patterns among Italian older adults: a retrospective cohort study
CONCLUSIONS: A sizeable proportion of older adults who received other recommended vaccines during the last influenza season did not receive SIV. This share of missed opportunities, which are subject to some social inequalities, may be addressed by increasing vaccine co-administration rates and implementing tailored health promotion interventions.PMID:37632235 | DOI:10.1093/eurpub/ckad155
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Alexander Domnich Andrea Orsi Matilde Ogliastro Carlo-Simone Trombetta Marianna Scarpaleggia Chiara Ceccaroli Carla Amadio Anna Raffo Luca Berisso Alla Yakubovich Giacomo Zappa Daniela Amicizia Donatella Panatto Giancarlo Icardi Source Type: research
Lives of Skin Lesions in Monkeypox: Histomorphological, Immunohistochemical, and Clinical Correlations in a Small Case Series
In this study, we evaluated skin biopsies of all stages. Therefore, five biopsies from four patients were analyzed histologically, immunohistochemically with anti-Vaccinia virus antibodies, and electron-microscopically. Notably, the early macular stage only showed subtle viropathic changes; it did not express of Orthopoxvirus proteins in immunohistochemistry and therefore can easily be missed histologically. In later stages, immunohistochemistry with anti-Vaccinia virus antibodies might be useful to distinguish mpox from differential diagnoses such as herpes virus infections. In the ulcerative stages, the identified occlus...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Paul Schmidle Sonja Leson Ulrike Wieland Almut B öer-Auer Dieter Metze Stephan A Braun Source Type: research
Variant Analysis of the Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus in Korea: Frequency of Acyclovir Resistance Mutations
Viruses. 2023 Aug 9;15(8):1709. doi: 10.3390/v15081709.ABSTRACTThe thymidine kinase (TK) and DNA polymerase (pol) genes of the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are two important genes involved in antiviral resistance. We investigated the genetic polymorphisms of the HSV-TK and pol genes in clinical isolates from Korean HSV-infected patients using next-generation sequencing (NGS) for the first time in Korea. A total of 81 HSV-1 and 47 HSV-2 isolates were examined. NGS was used to amplify and sequence the TK and pol genes. Among the 81 HSV-1 isolates, 12 and 17 natural polymorphisms and 9 and 23 polym...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Jungwon Hyun Su Kyung Lee Ji Hyun Kim Eun-Jung Cho Han-Sung Kim Jae-Seok Kim Wonkeun Song Hyun Soo Kim Source Type: research
The Spectrum of Neurological Manifestations of Varicella-Zoster Virus Reactivation
Viruses. 2023 Jul 30;15(8):1663. doi: 10.3390/v15081663.ABSTRACTVaricella-Zoster virus (VZV) is a pathogenic human alpha herpes virus that causes varicella (chicken pox) as a primary infection and, following a variable period of latency in different ganglionic neurons, it reactivates to produce herpes zoster (shingles). The focus of this review is on the wide spectrum of the possible neurological manifestations of VZV reactivation. While the most frequent reactivation syndrome is herpes zoster, this may be followed by the serious and painful post-herpetic neuralgia (PHN) and by many other neurological conditions. Prominent...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Peter G E Kennedy Source Type: research
Mechanistic Understanding of the Antiviral Properties of Pistachios and Zeaxanthin against HSV-1
Viruses. 2023 Jul 29;15(8):1651. doi: 10.3390/v15081651.ABSTRACTThe search for alternative clinical treatments to fight resistance and find alternative antiviral treatments for the herpes simplex virus (HSV) is of great interest. Plants are rich sources of novel antiviral, pharmacologically active agents that provide several advantages, including reduced side effects, less resistance, low toxicity, and different mechanisms of action. In the present work, the antiviral activity of Californian natural raw (NRRE) and roasted unsalted (RURE) pistachio polyphenols-rich extracts was evaluated against HSV-1 using VERO cells. Two ...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Rosamaria Pennisi Paola Trischitta Maria Pia Tamburello Davide Barreca Giuseppina Mandalari Maria Teresa Sciortino Source Type: research
< em > Lavandula austroapennina < /em > : Assessment of the Antiviral Activity of Lipophilic Extracts from Its Organs
This study underlines how much knowledge of a territory's medicinal plant heritage is a harbinger of promising discoveries in the health field.PMID:37631991 | DOI:10.3390/v15081648
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Annalisa Chianese Claudia Gravina Maria Vittoria Morone Annalisa Ambrosino Marialuisa Formato Francesca Palma Francesco Foglia Bianca Maria Nastri Carla Zannella Assunta Esposito Anna De Filippis Simona Piccolella Massimiliano Galdiero Severina Pacifico Source Type: research
BMS-265246, a Cyclin-Dependent Kinase Inhibitor, Inhibits the Infection of Herpes Simplex Virus Type 1
In this study, we examined a panel of CDK inhibitors that target CDKs in the present study. BMS-265246 (BMS), a CDK 1/2 inhibitor, was found to effectively limit HSV-1 multiplication in Vero, HepG2, and Hela cells. A mechanism of action study suggested that BMS inhibits the early stages of viral replication when added early in the viral infection. The suppression of multiple steps in viral replication by BMS was revealed when HSV-1 infected cells were treated at different time periods in the viral life cycle. Our results suggest that BMS is a potent anti-HSV-1 agent and unique in that it may interfere with multiple steps i...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Lefang Jiang Yang Yu Zhuogang Li Yarou Gao Haonan Zhang Mingxin Zhang Weihua Cao Qun Peng Xulin Chen Source Type: research
Greater Durability and Protection against Herpes Simplex Viral Disease following Immunization of Mice with Single-Cycle ΔgD-2 Compared to an Adjuvanted Glycoprotein D Protein Vaccine
Vaccines (Basel). 2023 Aug 14;11(8):1362. doi: 10.3390/vaccines11081362.ABSTRACTHerpes simplex viruses (HSV) cause chronic infections with significant morbidity. Prior vaccines, designed to generate neutralizing antibodies (nAbs) targeting glycoprotein D (gD), failed to provide durable protection. We adopted a different strategy and evaluated a single-cycle virus deleted in gD (ΔgD-2). ΔgD-2elicits antibodies that primarily mediate antibody-dependent cell mediated cytolysis (ADCC) and provides complete protection against clinical isolates of HSV in multiple lethal mouse models. To assess durability, we vaccinated mice (2...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Aakash Mahant Mahant Matthew S Gromisch Leah Kravets Clare Burn Aschner Betsy C Herold Source Type: research
New Imidazolium Alkaloids with Broad Spectrum of Action from the Marine Bacterium < em > Shewanella aquimarina < /em >
Pharmaceutics. 2023 Aug 14;15(8):2139. doi: 10.3390/pharmaceutics15082139.ABSTRACTThe continuous outbreak of drug-resistant bacterial and viral infections imposes the need to search for new drug candidates. Natural products from marine bacteria still inspire the design of pharmaceuticals. Indeed, marine bacteria have unique metabolic flexibility to inhabit each ecological niche, thus expanding their biosynthetic ability to assemble unprecedented molecules. The One-Strain-Many-Compounds approach and tandem mass spectrometry allowed the discovery of a Shewanella aquimarina strain as a source of novel imidazolium alkaloids vi...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Rosa Giugliano Gerardo Della Sala Carmine Buonocore Carla Zannella Pietro Tedesco Fortunato Palma Esposito Costanza Ragozzino Annalisa Chianese Maria Vittoria Morone Valerio Mazzella Laura N úñez-Pons Veronica Folliero Gianluigi Franci Anna De Filippis Source Type: research
Early Events after Herpes Simplex Virus-Type 1 Entry Are Necessary for the Release of Gamma-Hydroxybutyrate upon Acute Infection
This study aims to shed light on the biochemical pathway and the stage within the viral life cycle responsible for the release of GHB in infected cells. UV-inactivation, acyclovir (ACV), and cycloheximide (CHX) treatments were used to inhibit HSV-1 replication at various stages. Vero cells treated with UV-inactivated HSV-1 significantly decreased GHB production. However, ACV or CHX treatments did not affect GHB production. We also showed that inhibition of glycolytic enzyme enolase by sodium fluoride (NaF) significantly reduces GHB production upon infection. This finding suggests that suppression of glycolytic activity neg...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Faith O Osinaga Yu-Chih Chen Madan K Kharel Yan Waguespack Sichu Li Shaochung Victor Hsia Source Type: research
Seroprevalence of Infections with TORCH Agents in Romania: A Systematic Review
This study highlights the importance of continuous monitoring and preventive measures such as vaccinations and awareness campaigns to mitigate the health impact on the pregnant population.PMID:37630680 | DOI:10.3390/microorganisms11082120
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Cristiana Luiza Radoi Ovidiu Zlatian Maria Balasoiu Lucian Giubelan Andreea Cristina Stoian Livia Dragonu Alexandru Neacsu Dominic Gabriel Iliescu Source Type: research
Herpes Simplex Virus Type 1 Infection Induces the Formation of Tunneling Nanotubes
Microorganisms. 2023 Jul 28;11(8):1916. doi: 10.3390/microorganisms11081916.ABSTRACTHerpes simplex virus type 1 (HSV-1) is human specific virus. The intercellular transmission of HSV-1 is essential in its pathogenesis. The tunneling nanotube (TNT), a new mode connecting distant cells, has been found to play an important role in the spread of various viruses like human immunodeficiency virus (HIV) and influenza virus. However, whether HSV-1 can be transmitted through TNTs has not been confirmed. The purpose of this study was to clarify this, and further to determine the effect of inhibiting the actin-related protein 2/3 (Ar...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Jie Wang Kun-Te Shang Qiong-Hong Ma Zhao-Ying Dong Yi-Hong Chen Yu-Feng Yao Source Type: research
Instantaneous Inactivation of Herpes Simplex Virus by Silicon Nitride Bioceramics
Int J Mol Sci. 2023 Aug 10;24(16):12657. doi: 10.3390/ijms241612657.ABSTRACTHydrolytic reactions taking place at the surface of a silicon nitride (Si3N4) bioceramic were found to induce instantaneous inactivation of Human herpesvirus 1 (HHV-1, also known as Herpes simplex virus 1 or HSV-1). Si3N4 is a non-oxide ceramic compound with strong antibacterial and antiviral properties that has been proven safe for human cells. HSV-1 is a double-stranded DNA virus that infects a variety of host tissues through a lytic and latent cycle. Real-time reverse transcription (RT)-polymerase chain reaction (PCR) tests of HSV-1 DNA after in...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Giuseppe Pezzotti Eriko Ohgitani Saki Ikegami Masaharu Shin-Ya Tetsuya Adachi Toshiro Yamamoto Narisato Kanamura Elia Marin Wenliang Zhu Kazu Okuma Osam Mazda Source Type: research
Multiple Administration Routes, Including Intramuscular Injection, of Oncolytic Tanapoxvirus Variants Significantly Regress Human Melanoma Xenografts in BALB/c Nude Mice Reconstituted with Splenocytes from Normal BALB/c Donors
In this study, TPV/Δ66R/mIL-2 and TPV/Δ2L/Δ66R/FliC were tested for their ability to treat human melanoma xenografts (SK-MEL3) in a BALB/c nude mouse model reconstituted with splenocytes from genetically compatible, normal BALB/c donor mice. Two SK-MEL3 tumors were transplanted into each flank of BALB/c nude mice, and the larger tumor was treated intratumorally (IT) with virus or mock injection. In one set of animals, mice received adoptive transfers of splenocytes from BALB/c mice on day 4 to reconstitute their immune systems and allow for adaptive immune responses to occur in a xenograft model. Direct IT injection of ...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Michael L Monaco Omer A Idris Grace A Filpi Steven L Kohler Scott D Haller Jeffery E Burr Robert Eversole Karim Essani Source Type: research
