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Source: International Journal of Molecular Medicine
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Total 2185 results found since Jan 2013.
Characterization of circRNAs in established osimertinib ‑resistant non‑small cell lung cancer cell lines
In conclusion, the present study established osimertinib‑resistant cell lines and revealed that circRNAs may serve as a promising biomarker in NSCLC osimertinib resistance.PMID:37681495 | DOI:10.3892/ijmm.2023.5305
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Xin Chen Jingyao Gu Jiali Huang Kang Wen Ge Zhang Zhenyao Chen Zhaoxia Wang Source Type: research
Corrigendum Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
Int J Mol Med. 2023 Nov;52(5):100. doi: 10.3892/ijmm.2023.5303. Epub 2023 Sep 8.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the western blots shown in Fig. 4 on p. 610, the two leftmost bands shown for the Bax data in Fig. 4A were strikingly similar to the two rightmost Mito Cyt C bands featured in Fig. 4C. The authors have checked their original data, and realized that these data were assembled incorrectly in this figure. The revised version of Fig. 4 is shown below, now featuring the correct Bax data in Fig. 4A. The authors confirm that the errors ...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Jian Du Bo Tang Jingwen Wang Hongtao Sui Xueli Jin Liming Wang Zhongyu Wang Source Type: research
Role of transcription factor FOXM1 in diabetes and its complications (Review)
Int J Mol Med. 2023 Nov;52(5):101. doi: 10.3892/ijmm.2023.5304. Epub 2023 Sep 8.ABSTRACTDiabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biolog...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Baoqing Zhao Mengxi Li Yanting Su Shigang Shan Wenbin Qian Dan Zhu Xiufen Liu Zhenwang Zhang Source Type: research
UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF ‑1α‑mediated mitophagy
Int J Mol Med. 2023 Oct;52(4):99. doi: 10.3892/ijmm.2023.5302. Epub 2023 Sep 8.ABSTRACTStem cell‑based tissue engineering has shown significant potential for rapid restoration of injured cartilage tissues. Stem cells frequently undergo apoptosis because of the prevalence of oxidative stress and inflammation in the microenvironment at the sites of injury. Our previous study demonstrated that stabilization of hypoxia‑inducible factor 1α (HIF‑1α) is key to resisting apoptosis in chondrocytes. Recently, it was reported that Ubiquitin C‑terminal hydrolase L1 (UCHL1) can stabilize HIF‑1α by abrogating the ubiquitina...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qiqian Yan Shanwei Shi Yang Ge Shuangquan Wan Mingfei Li Maoquan Li Source Type: research
Characterization of circRNAs in established osimertinib ‑resistant non‑small cell lung cancer cell lines
In conclusion, the present study established osimertinib‑resistant cell lines and revealed that circRNAs may serve as a promising biomarker in NSCLC osimertinib resistance.PMID:37681495 | DOI:10.3892/ijmm.2023.5305
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Xin Chen Jingyao Gu Jiali Huang Kang Wen Ge Zhang Zhenyao Chen Zhaoxia Wang Source Type: research
Corrigendum Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
Int J Mol Med. 2023 Nov;52(5):100. doi: 10.3892/ijmm.2023.5303. Epub 2023 Sep 8.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the western blots shown in Fig. 4 on p. 610, the two leftmost bands shown for the Bax data in Fig. 4A were strikingly similar to the two rightmost Mito Cyt C bands featured in Fig. 4C. The authors have checked their original data, and realized that these data were assembled incorrectly in this figure. The revised version of Fig. 4 is shown below, now featuring the correct Bax data in Fig. 4A. The authors confirm that the errors ...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Jian Du Bo Tang Jingwen Wang Hongtao Sui Xueli Jin Liming Wang Zhongyu Wang Source Type: research
Role of transcription factor FOXM1 in diabetes and its complications (Review)
Int J Mol Med. 2023 Nov;52(5):101. doi: 10.3892/ijmm.2023.5304. Epub 2023 Sep 8.ABSTRACTDiabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biolog...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Baoqing Zhao Mengxi Li Yanting Su Shigang Shan Wenbin Qian Dan Zhu Xiufen Liu Zhenwang Zhang Source Type: research
UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF ‑1α‑mediated mitophagy
Int J Mol Med. 2023 Oct;52(4):99. doi: 10.3892/ijmm.2023.5302. Epub 2023 Sep 8.ABSTRACTStem cell‑based tissue engineering has shown significant potential for rapid restoration of injured cartilage tissues. Stem cells frequently undergo apoptosis because of the prevalence of oxidative stress and inflammation in the microenvironment at the sites of injury. Our previous study demonstrated that stabilization of hypoxia‑inducible factor 1α (HIF‑1α) is key to resisting apoptosis in chondrocytes. Recently, it was reported that Ubiquitin C‑terminal hydrolase L1 (UCHL1) can stabilize HIF‑1α by abrogating the ubiquitina...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qiqian Yan Shanwei Shi Yang Ge Shuangquan Wan Mingfei Li Maoquan Li Source Type: research
Corrigendum Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
Int J Mol Med. 2023 Nov;52(5):100. doi: 10.3892/ijmm.2023.5303. Epub 2023 Sep 8.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the western blots shown in Fig. 4 on p. 610, the two leftmost bands shown for the Bax data in Fig. 4A were strikingly similar to the two rightmost Mito Cyt C bands featured in Fig. 4C. The authors have checked their original data, and realized that these data were assembled incorrectly in this figure. The revised version of Fig. 4 is shown below, now featuring the correct Bax data in Fig. 4A. The authors confirm that the errors ...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Jian Du Bo Tang Jingwen Wang Hongtao Sui Xueli Jin Liming Wang Zhongyu Wang Source Type: research
Role of transcription factor FOXM1 in diabetes and its complications (Review)
Int J Mol Med. 2023 Nov;52(5):101. doi: 10.3892/ijmm.2023.5304. Epub 2023 Sep 8.ABSTRACTDiabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biolog...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Baoqing Zhao Mengxi Li Yanting Su Shigang Shan Wenbin Qian Dan Zhu Xiufen Liu Zhenwang Zhang Source Type: research
UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF ‑1α‑mediated mitophagy
Int J Mol Med. 2023 Oct;52(4):99. doi: 10.3892/ijmm.2023.5302. Epub 2023 Sep 8.ABSTRACTStem cell‑based tissue engineering has shown significant potential for rapid restoration of injured cartilage tissues. Stem cells frequently undergo apoptosis because of the prevalence of oxidative stress and inflammation in the microenvironment at the sites of injury. Our previous study demonstrated that stabilization of hypoxia‑inducible factor 1α (HIF‑1α) is key to resisting apoptosis in chondrocytes. Recently, it was reported that Ubiquitin C‑terminal hydrolase L1 (UCHL1) can stabilize HIF‑1α by abrogating the ubiquitina...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qiqian Yan Shanwei Shi Yang Ge Shuangquan Wan Mingfei Li Maoquan Li Source Type: research
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
Role of RIPK3 ‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases (Review)
Int J Mol Med. 2023 Oct;52(4):98. doi: 10.3892/ijmm.2023.5301. Epub 2023 Sep 1.ABSTRACTNecroptosis, which is distinct from apoptosis and necrosis, serves a crucial role in ontogeny and the maintenance of homeostasis. In the last decade, it has been demonstrated that the pathogenesis of cardiovascular diseases is also linked to necroptosis. Receptor interaction protein kinase (RIPK) 1, RIPK3 and mixed lineage kinase domain‑like protein serve vital roles in necroptosis. In addition to the aforementioned necroptosis‑related components, calcium/calmodulin‑dependent protein kinase II (CaMKII) has been identified as a nove...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Sheng Chen Senhong Guan Zhaohan Yan Fengshan Ouyang Shuhuan Li Lanyuan Liu Jiankai Zhong Source Type: research
Adropin attenuates pancreatitis ‑associated lung injury through PPARγ phosphorylation‑related macrophage polarization
Int J Mol Med. 2023 Oct;52(4):95. doi: 10.3892/ijmm.2023.5298. Epub 2023 Sep 1.ABSTRACTAcute pancreatitis (AP)‑associated lung injury (ALI) is a critical complication of AP. Adropin is a regulatory protein of immune metabolism. The present study aimed to explore the immunomodulatory effects of adropin on AP‑ALI. For this purpose, serum samples of patients with AP were collected and the expression levels of serum adropin were detected using ELISA. Animal models of AP and adropin knockout (Adro‑KO) were constructed, and adropin expression in serum and lung tissues was investigated. The levels of fibrosis and apoptosis ...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Fadian Ding Guozhong Liu Feng Gao Zhou Zheng Yupu Hong Youting Chen Shangeng Weng Source Type: research
Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1 α/NOD1/NF‑κB pathway
Int J Mol Med. 2023 Oct;52(4):96. doi: 10.3892/ijmm.2023.5299. Epub 2023 Sep 1.ABSTRACTFine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for various periods of time, and cell viability was determined using a Cell Counting Kit‑8 assay. The results of the present study demonst...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Lihua Hu Chaoqun Xu Xiang Tang Shanjun Yu Lijun Wang Qi Li Xiangdong Zhou Source Type: research
