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Source: International Journal of Molecular Medicine
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Total 2185 results found since Jan 2013.
Corrigendum MicroRNA ‑218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1
Int J Mol Med. 2023 Aug;52(2):66. doi: 10.3892/ijmm.2023.5269. Epub 2023 Jun 23.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that the 'Control' and 'miR‑218 / BMI1' data panels for the Transwell invasion assay experiments shown in Figs. 4D and 5D on p. 100 and 101 respectively contained apparently overlapping data, albeit presented in different orientations, such that these data would have been derived from the same original source, even though they were intended to have shown the results from different experiments. On re‑examining their original data, the ...
Source: International Journal of Molecular Medicine - June 23, 2023 Category: Molecular Biology Authors: Ting Wang Tengfei Chen Hua Niu Chang Li Chun Xu Yuanyuan Li Rui Huang Jun Zhao Shuyan Wu Source Type: research
Inflammation and coagulation abnormalities via the activation of the HMGB1‑RAGE/NF‑κB and F2/Rho pathways in lung injury induced by acute hypoxia
Int J Mol Med. 2023 Aug;52(2):67. doi: 10.3892/ijmm.2023.5270. Epub 2023 Jun 23.ABSTRACTHigh‑altitude acute hypoxia is commonly associated with respiratory cardiovascular diseases. The inability to adapt to acute hypoxia may lead to cardiovascular dysfunction, lung injury and even death. Therefore, understanding the molecular basis of the adaptation to high‑altitude acute hypoxia may reveal novel therapeutic approaches with which to counteract the detrimental consequences of hypoxia. In the present study, a high‑altitude environment was simulated in a rat model in order to investigate the role of the high mobility gr...
Source: International Journal of Molecular Medicine - June 23, 2023 Category: Molecular Biology Authors: Jing Gao Zhuo Zhang Jia-Yi Yan Yun-Xuan Ge Yue Gao Source Type: research
Corrigendum Celecoxib inhibits the epithelial ‑to‑mesenchymal transition in bladder cancer via the miRNA‑145/TGFBR2/Smad3 axis
Int J Mol Med. 2023 Aug;52(2):64. doi: 10.3892/ijmm.2023.5267. Epub 2023 Jun 16.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell migration assays shown in Figs. 1B and 3B on p. 685 and p. 688 respectively, the images selected for the '5637 / DMSO' experiment in Fig. 1B and the DMSO experiment in Fig. 3B were apparently the same, such that these data appeared to have been derived from the same original source. After having consulted their original data, the authors have realized that the 5637 DMSO data panel in Fig. 3B had been selected incor...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Xiaoqiang Liu Yanlong Wu Zhengtao Zhou Mingchuan Huang Wen Deng Yibing Wang Xiaochen Zhou Luyao Chen Yu Li Tao Zeng Gongxian Wang Bin Fu Source Type: research
< em > Paeonia lactiflora < /em > root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3 ‑L1 cells
Int J Mol Med. 2023 Aug;52(2):65. doi: 10.3892/ijmm.2023.5268. Epub 2023 Jun 16.ABSTRACTObesity is associated with high risk of mortality globally because obesity is associated with development of diseases such as diabetes, dyslipidemia, fatty liver disease, hypertension, and cancer. The present study aimed to identify the mechanism of action related to the anti‑obesity activity of Paeonia lactiflora root (PLR) based on its effects on lipid droplet accumulation. The inhibitory activity on lipid accumulation was analyzed through Oil‑Red O staining, and the changes in levels of lipid accumulation‑related proteins were ...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Jeong Won Choi Hyeok Jin Choi Gwang Hyeon Ryu Jae Won Lee Jueng Kyu Beak Eun Jeong Koh Jin Boo Jeong Source Type: research
Corrigendum Celecoxib inhibits the epithelial ‑to‑mesenchymal transition in bladder cancer via the miRNA‑145/TGFBR2/Smad3 axis
Int J Mol Med. 2023 Aug;52(2):64. doi: 10.3892/ijmm.2023.5267. Epub 2023 Jun 16.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell migration assays shown in Figs. 1B and 3B on p. 685 and p. 688 respectively, the images selected for the '5637 / DMSO' experiment in Fig. 1B and the DMSO experiment in Fig. 3B were apparently the same, such that these data appeared to have been derived from the same original source. After having consulted their original data, the authors have realized that the 5637 DMSO data panel in Fig. 3B had been selected incor...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Xiaoqiang Liu Yanlong Wu Zhengtao Zhou Mingchuan Huang Wen Deng Yibing Wang Xiaochen Zhou Luyao Chen Yu Li Tao Zeng Gongxian Wang Bin Fu Source Type: research
< em > Paeonia lactiflora < /em > root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3 ‑L1 cells
Int J Mol Med. 2023 Aug;52(2):65. doi: 10.3892/ijmm.2023.5268. Epub 2023 Jun 16.ABSTRACTObesity is associated with high risk of mortality globally because obesity is associated with development of diseases such as diabetes, dyslipidemia, fatty liver disease, hypertension, and cancer. The present study aimed to identify the mechanism of action related to the anti‑obesity activity of Paeonia lactiflora root (PLR) based on its effects on lipid droplet accumulation. The inhibitory activity on lipid accumulation was analyzed through Oil‑Red O staining, and the changes in levels of lipid accumulation‑related proteins were ...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Jeong Won Choi Hyeok Jin Choi Gwang Hyeon Ryu Jae Won Lee Jueng Kyu Beak Eun Jeong Koh Jin Boo Jeong Source Type: research
Corrigendum Celecoxib inhibits the epithelial ‑to‑mesenchymal transition in bladder cancer via the miRNA‑145/TGFBR2/Smad3 axis
Int J Mol Med. 2023 Aug;52(2):64. doi: 10.3892/ijmm.2023.5267. Epub 2023 Jun 16.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell migration assays shown in Figs. 1B and 3B on p. 685 and p. 688 respectively, the images selected for the '5637 / DMSO' experiment in Fig. 1B and the DMSO experiment in Fig. 3B were apparently the same, such that these data appeared to have been derived from the same original source. After having consulted their original data, the authors have realized that the 5637 DMSO data panel in Fig. 3B had been selected incor...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Xiaoqiang Liu Yanlong Wu Zhengtao Zhou Mingchuan Huang Wen Deng Yibing Wang Xiaochen Zhou Luyao Chen Yu Li Tao Zeng Gongxian Wang Bin Fu Source Type: research
< em > Paeonia lactiflora < /em > root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3 ‑L1 cells
Int J Mol Med. 2023 Aug;52(2):65. doi: 10.3892/ijmm.2023.5268. Epub 2023 Jun 16.ABSTRACTObesity is associated with high risk of mortality globally because obesity is associated with development of diseases such as diabetes, dyslipidemia, fatty liver disease, hypertension, and cancer. The present study aimed to identify the mechanism of action related to the anti‑obesity activity of Paeonia lactiflora root (PLR) based on its effects on lipid droplet accumulation. The inhibitory activity on lipid accumulation was analyzed through Oil‑Red O staining, and the changes in levels of lipid accumulation‑related proteins were ...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Jeong Won Choi Hyeok Jin Choi Gwang Hyeon Ryu Jae Won Lee Jueng Kyu Beak Eun Jeong Koh Jin Boo Jeong Source Type: research
Corrigendum Celecoxib inhibits the epithelial ‑to‑mesenchymal transition in bladder cancer via the miRNA‑145/TGFBR2/Smad3 axis
Int J Mol Med. 2023 Aug;52(2):64. doi: 10.3892/ijmm.2023.5267. Epub 2023 Jun 16.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell migration assays shown in Figs. 1B and 3B on p. 685 and p. 688 respectively, the images selected for the '5637 / DMSO' experiment in Fig. 1B and the DMSO experiment in Fig. 3B were apparently the same, such that these data appeared to have been derived from the same original source. After having consulted their original data, the authors have realized that the 5637 DMSO data panel in Fig. 3B had been selected incor...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Xiaoqiang Liu Yanlong Wu Zhengtao Zhou Mingchuan Huang Wen Deng Yibing Wang Xiaochen Zhou Luyao Chen Yu Li Tao Zeng Gongxian Wang Bin Fu Source Type: research
< em > Paeonia lactiflora < /em > root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3 ‑L1 cells
Int J Mol Med. 2023 Aug;52(2):65. doi: 10.3892/ijmm.2023.5268. Epub 2023 Jun 16.ABSTRACTObesity is associated with high risk of mortality globally because obesity is associated with development of diseases such as diabetes, dyslipidemia, fatty liver disease, hypertension, and cancer. The present study aimed to identify the mechanism of action related to the anti‑obesity activity of Paeonia lactiflora root (PLR) based on its effects on lipid droplet accumulation. The inhibitory activity on lipid accumulation was analyzed through Oil‑Red O staining, and the changes in levels of lipid accumulation‑related proteins were ...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Jeong Won Choi Hyeok Jin Choi Gwang Hyeon Ryu Jae Won Lee Jueng Kyu Beak Eun Jeong Koh Jin Boo Jeong Source Type: research
Corrigendum Celecoxib inhibits the epithelial ‑to‑mesenchymal transition in bladder cancer via the miRNA‑145/TGFBR2/Smad3 axis
Int J Mol Med. 2023 Aug;52(2):64. doi: 10.3892/ijmm.2023.5267. Epub 2023 Jun 16.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell migration assays shown in Figs. 1B and 3B on p. 685 and p. 688 respectively, the images selected for the '5637 / DMSO' experiment in Fig. 1B and the DMSO experiment in Fig. 3B were apparently the same, such that these data appeared to have been derived from the same original source. After having consulted their original data, the authors have realized that the 5637 DMSO data panel in Fig. 3B had been selected incor...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Xiaoqiang Liu Yanlong Wu Zhengtao Zhou Mingchuan Huang Wen Deng Yibing Wang Xiaochen Zhou Luyao Chen Yu Li Tao Zeng Gongxian Wang Bin Fu Source Type: research
< em > Paeonia lactiflora < /em > root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3 ‑L1 cells
Int J Mol Med. 2023 Aug;52(2):65. doi: 10.3892/ijmm.2023.5268. Epub 2023 Jun 16.ABSTRACTObesity is associated with high risk of mortality globally because obesity is associated with development of diseases such as diabetes, dyslipidemia, fatty liver disease, hypertension, and cancer. The present study aimed to identify the mechanism of action related to the anti‑obesity activity of Paeonia lactiflora root (PLR) based on its effects on lipid droplet accumulation. The inhibitory activity on lipid accumulation was analyzed through Oil‑Red O staining, and the changes in levels of lipid accumulation‑related proteins were ...
Source: International Journal of Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Jeong Won Choi Hyeok Jin Choi Gwang Hyeon Ryu Jae Won Lee Jueng Kyu Beak Eun Jeong Koh Jin Boo Jeong Source Type: research
Obesity alters inflammatory response in the pathology of asthma (Review)
Int J Mol Med. 2023 Jul;52(1):63. doi: 10.3892/ijmm.2023.5266. Epub 2023 Jun 9.ABSTRACTObesity is one of the comorbidities in patients with asthma and obese patients with asthma present with a distinct phenotype with more severe disease outcomes and reduced responsiveness to standard therapies. Although the full mechanisms of obesity‑related asthma are still not completely understood, abnormal immune responses have been demonstrated to have a critical role in asthma pathogenesis. The present review summarizes the data from clinical, epidemiological and animal studies to provide an updated understanding of the immune resp...
Source: International Journal of Molecular Medicine - June 9, 2023 Category: Molecular Biology Authors: Ziwen Qin Hong Yang Junli Liu Dongxiao Li Yue Wang Yujuan Chen Chuanjun Huang Source Type: research
