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Source: International Journal of Molecular Medicine
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Total 2185 results found since Jan 2013.
METTL14 ‑mediated RNA methylation in digestive system tumors
Int J Mol Med. 2023 Sep;52(3):86. doi: 10.3892/ijmm.2023.5289. Epub 2023 Aug 4.ABSTRACTN6‑methyladenosine (m6A) RNA methylation is one of the most common post‑transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase‑like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different ...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Jiexuan Hu Haishan Lin Cong Wang Qiang Su Bangwei Cao Source Type: research
Retracted NR4A1 promotes TNF ‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway
Int J Mol Med. 2023 Sep;52(3):85. doi: 10.3892/ijmm.2023.5288. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that fluorescence microscopy data shown in Fig. 2C were strikingly similar to data appearing in different form in Fig. 3G in a previously published paper by different authors at different research institutes [Jieensinue S, Zhu H, Li G, Dong K, Liang M and Li Y: Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK‑Mff signaling pathways. BMC Cell Biology 19: 21, 2018]...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Zhibo Zheng Shuai Xiang Yingjie Wang Yulei Dong Zeng Li Yongbo Xiang Yanyan Bian Bin Feng Bo Yang Xisheng Weng Source Type: research
METTL14 ‑mediated RNA methylation in digestive system tumors
Int J Mol Med. 2023 Sep;52(3):86. doi: 10.3892/ijmm.2023.5289. Epub 2023 Aug 4.ABSTRACTN6‑methyladenosine (m6A) RNA methylation is one of the most common post‑transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase‑like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different ...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Jiexuan Hu Haishan Lin Cong Wang Qiang Su Bangwei Cao Source Type: research
Retracted NR4A1 promotes TNF ‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway
Int J Mol Med. 2023 Sep;52(3):85. doi: 10.3892/ijmm.2023.5288. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that fluorescence microscopy data shown in Fig. 2C were strikingly similar to data appearing in different form in Fig. 3G in a previously published paper by different authors at different research institutes [Jieensinue S, Zhu H, Li G, Dong K, Liang M and Li Y: Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK‑Mff signaling pathways. BMC Cell Biology 19: 21, 2018]...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Zhibo Zheng Shuai Xiang Yingjie Wang Yulei Dong Zeng Li Yongbo Xiang Yanyan Bian Bin Feng Bo Yang Xisheng Weng Source Type: research
METTL14 ‑mediated RNA methylation in digestive system tumors
Int J Mol Med. 2023 Sep;52(3):86. doi: 10.3892/ijmm.2023.5289. Epub 2023 Aug 4.ABSTRACTN6‑methyladenosine (m6A) RNA methylation is one of the most common post‑transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase‑like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different ...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Jiexuan Hu Haishan Lin Cong Wang Qiang Su Bangwei Cao Source Type: research
Retracted NR4A1 promotes TNF ‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway
Int J Mol Med. 2023 Sep;52(3):85. doi: 10.3892/ijmm.2023.5288. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that fluorescence microscopy data shown in Fig. 2C were strikingly similar to data appearing in different form in Fig. 3G in a previously published paper by different authors at different research institutes [Jieensinue S, Zhu H, Li G, Dong K, Liang M and Li Y: Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK‑Mff signaling pathways. BMC Cell Biology 19: 21, 2018]...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Zhibo Zheng Shuai Xiang Yingjie Wang Yulei Dong Zeng Li Yongbo Xiang Yanyan Bian Bin Feng Bo Yang Xisheng Weng Source Type: research
METTL14 ‑mediated RNA methylation in digestive system tumors
Int J Mol Med. 2023 Sep;52(3):86. doi: 10.3892/ijmm.2023.5289. Epub 2023 Aug 4.ABSTRACTN6‑methyladenosine (m6A) RNA methylation is one of the most common post‑transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase‑like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different ...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Jiexuan Hu Haishan Lin Cong Wang Qiang Su Bangwei Cao Source Type: research
Retracted NR4A1 promotes TNF ‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway
Int J Mol Med. 2023 Sep;52(3):85. doi: 10.3892/ijmm.2023.5288. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that fluorescence microscopy data shown in Fig. 2C were strikingly similar to data appearing in different form in Fig. 3G in a previously published paper by different authors at different research institutes [Jieensinue S, Zhu H, Li G, Dong K, Liang M and Li Y: Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK‑Mff signaling pathways. BMC Cell Biology 19: 21, 2018]...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Zhibo Zheng Shuai Xiang Yingjie Wang Yulei Dong Zeng Li Yongbo Xiang Yanyan Bian Bin Feng Bo Yang Xisheng Weng Source Type: research
METTL14 ‑mediated RNA methylation in digestive system tumors
Int J Mol Med. 2023 Sep;52(3):86. doi: 10.3892/ijmm.2023.5289. Epub 2023 Aug 4.ABSTRACTN6‑methyladenosine (m6A) RNA methylation is one of the most common post‑transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase‑like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different ...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Jiexuan Hu Haishan Lin Cong Wang Qiang Su Bangwei Cao Source Type: research
Retracted NR4A1 promotes TNF ‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway
Int J Mol Med. 2023 Sep;52(3):85. doi: 10.3892/ijmm.2023.5288. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that fluorescence microscopy data shown in Fig. 2C were strikingly similar to data appearing in different form in Fig. 3G in a previously published paper by different authors at different research institutes [Jieensinue S, Zhu H, Li G, Dong K, Liang M and Li Y: Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK‑Mff signaling pathways. BMC Cell Biology 19: 21, 2018]...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Zhibo Zheng Shuai Xiang Yingjie Wang Yulei Dong Zeng Li Yongbo Xiang Yanyan Bian Bin Feng Bo Yang Xisheng Weng Source Type: research
METTL14 ‑mediated RNA methylation in digestive system tumors
Int J Mol Med. 2023 Sep;52(3):86. doi: 10.3892/ijmm.2023.5289. Epub 2023 Aug 4.ABSTRACTN6‑methyladenosine (m6A) RNA methylation is one of the most common post‑transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase‑like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different ...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Jiexuan Hu Haishan Lin Cong Wang Qiang Su Bangwei Cao Source Type: research
Retracted NR4A1 promotes TNF ‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway
Int J Mol Med. 2023 Sep;52(3):85. doi: 10.3892/ijmm.2023.5288. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that fluorescence microscopy data shown in Fig. 2C were strikingly similar to data appearing in different form in Fig. 3G in a previously published paper by different authors at different research institutes [Jieensinue S, Zhu H, Li G, Dong K, Liang M and Li Y: Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK‑Mff signaling pathways. BMC Cell Biology 19: 21, 2018]...
Source: International Journal of Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Zhibo Zheng Shuai Xiang Yingjie Wang Yulei Dong Zeng Li Yongbo Xiang Yanyan Bian Bin Feng Bo Yang Xisheng Weng Source Type: research
RAS ‑stimulated release of exosomal < em > miR ‑494‑3p < /em > promotes the osteolytic bone metastasis of breast cancer cells
Int J Mol Med. 2023 Sep;52(3):84. doi: 10.3892/ijmm.2023.5287. Epub 2023 Jul 28.ABSTRACTRAS activation is a key determinant of breast cancer progression and metastasis. However, the role of the interaction among exosomes, RAS and microRNAs (miRNAs/miRs) in the osteolytic bone metastasis of breast cancer remains unclear. Therefore, the present study aimed to examine the role of activated RAS (KRAS, HRAS and NRAS) in the release of exosome‑mediated osteoclastogenic miRNAs and to elucidate their functional role in bone microenvironment remodeling in vitro and in vivo. Exosomes derived from RAS‑activated breast cancer cell...
Source: International Journal of Molecular Medicine - July 28, 2023 Category: Molecular Biology Authors: Okhwa Kim Phuong Thao Tran Minju Gal Se Jin Lee Sung Hun Na Cheol Hwangbo Jeong-Hyung Lee Source Type: research
Retracted Chronic alcohol exposure exacerbates inflammation and triggers pancreatic acinar ‑to‑ductal metaplasia through PI3K/Akt/IKK
Int J Mol Med. 2023 Sep;52(3):82. doi: 10.3892/ijmm.2023.5285. Epub 2023 Jul 28.ABSTRACTFollowing the publication of the above article, a concerned reader drew to the Editor's attention that there were a number of apparent anomalies associated with the western blots featured in Figs. 1C and E, 3A, C and E, 4A, C and E, 5B, 8A and C; moreover, the images shown for the immunohistochemical experiments in Fig. 8E contained groupings of cells that were markedly similar in appearance, comparing across the eight separate figure parts. After having conducted an internal investigation of the data in this paper, the Editor of Intern...
Source: International Journal of Molecular Medicine - July 28, 2023 Category: Molecular Biology Authors: Xin Huang Xuqi Li Qingyong Ma Qinhong Xu Wanxing Duan Jianjun Lei Lun Zhang Zheng Wu Source Type: research
