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Source: International Journal of Molecular Medicine
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Total 2185 results found since Jan 2013.
Involvement of the JNK/HO ‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells
In conclusion, NPs could induce inflammatory responses and ferroptosis in BV2 cells. JNK/HO‑1 mediated ferroptosis may serve an important role in the toxicity of microglia induced by NPs. This study provided novel evidence for the toxic effects of NPs and highlighted a theoretical mechanistic basis for safe prevention and treatment of plastic pollution‑induced neurotoxicity.PMID:37264973 | DOI:10.3892/ijmm.2023.5264
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Jiayin Sun Yihua Wang Yilun Du Wanxin Zhang Zuodong Liu Jin Bai Guanqun Cui Zhongjun Du Source Type: research
Impact of serum ‑free media on the expansion and functionality of CD19.CAR T‑cells
Int J Mol Med. 2023 Jul;52(1):58. doi: 10.3892/ijmm.2023.5261. Epub 2023 Jun 2.ABSTRACTFetal bovine serum (FBS) or human serum is widely used in the production of chimeric antigen receptor (CAR) T‑cells. In order to overcome a lot‑to‑lot inconsistency, the use of chemically defined medium that is free of animal-components would be highly desirable. The present study compared three serum‑free media [Prime‑XV™ T Cell CDM, Fujifilm™ (FF), LymphoONE™ T‑Cell Expansion Xeno‑Free Medium, Takara Bio™ (TB) and TCM GMP‑Prototype, CellGenix™ (CG)] to the standard CAR T‑cell medium containing FBS (RCF). Aft...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Franziska Eberhardt Angela H ückelhoven-Krauss Alexander Kunz Genqiao Jiang Tim Sauer Avinoam Reichman Brigitte Neuber Kathrin B öpple Anita Schmitt Carsten M üller-Tidow Michael Schmitt Anna Keib Source Type: research
Retracted TRIM16 suppresses the progression of prostate tumors by inhibiting the Snail signaling pathway
Int J Mol Med. 2023 Jul;52(1):59. doi: 10.3892/ijmm.2023.5262. Epub 2023 Jun 2.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by concerned readers that the western blotting data shown in Figs. 4C and 7B and D, the scratch‑wound assay images shown in Figs. 5A and 6A, and certain of the cell migration and invasion assay data shown in Figs. 5B and 6B were strikingly similar to data that had previously appeared in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Li Qi Zhong Lu Yong-Hong Sun Hai-Tao Song Wei-Kang Xu Source Type: research
Interaction between apical periodontitis and systemic disease (Review)
Int J Mol Med. 2023 Jul;52(1):60. doi: 10.3892/ijmm.2023.5263. Epub 2023 Jun 2.ABSTRACTApical periodontitis is an oral common inflammatory disease initiated by infection of pulp chamber and is characterized by destruction and resorption of the periapical bone. As a local infection, pathogens and their products in periapical tissues, as well as inflammatory cytokines produced in periapical lesions, enter the blood circulation, triggering systemic immune responses and leading to the pathogenesis of various types of systemic disease. Therefore, apical periodontitis might be associated with systemic disease rather than solely ...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Lanxiang Ye Li Cao Wencheng Song Chen Yang Qingming Tang Zhenglin Yuan Source Type: research
Involvement of the JNK/HO ‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells
In conclusion, NPs could induce inflammatory responses and ferroptosis in BV2 cells. JNK/HO‑1 mediated ferroptosis may serve an important role in the toxicity of microglia induced by NPs. This study provided novel evidence for the toxic effects of NPs and highlighted a theoretical mechanistic basis for safe prevention and treatment of plastic pollution‑induced neurotoxicity.PMID:37264973 | DOI:10.3892/ijmm.2023.5264
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Jiayin Sun Yihua Wang Yilun Du Wanxin Zhang Zuodong Liu Jin Bai Guanqun Cui Zhongjun Du Source Type: research
Impact of serum ‑free media on the expansion and functionality of CD19.CAR T‑cells
Int J Mol Med. 2023 Jul;52(1):58. doi: 10.3892/ijmm.2023.5261. Epub 2023 Jun 2.ABSTRACTFetal bovine serum (FBS) or human serum is widely used in the production of chimeric antigen receptor (CAR) T‑cells. In order to overcome a lot‑to‑lot inconsistency, the use of chemically defined medium that is free of animal-components would be highly desirable. The present study compared three serum‑free media [Prime‑XV™ T Cell CDM, Fujifilm™ (FF), LymphoONE™ T‑Cell Expansion Xeno‑Free Medium, Takara Bio™ (TB) and TCM GMP‑Prototype, CellGenix™ (CG)] to the standard CAR T‑cell medium containing FBS (RCF). Aft...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Franziska Eberhardt Angela H ückelhoven-Krauss Alexander Kunz Genqiao Jiang Tim Sauer Avinoam Reichman Brigitte Neuber Kathrin B öpple Anita Schmitt Carsten M üller-Tidow Michael Schmitt Anna Keib Source Type: research
Retracted TRIM16 suppresses the progression of prostate tumors by inhibiting the Snail signaling pathway
Int J Mol Med. 2023 Jul;52(1):59. doi: 10.3892/ijmm.2023.5262. Epub 2023 Jun 2.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by concerned readers that the western blotting data shown in Figs. 4C and 7B and D, the scratch‑wound assay images shown in Figs. 5A and 6A, and certain of the cell migration and invasion assay data shown in Figs. 5B and 6B were strikingly similar to data that had previously appeared in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Li Qi Zhong Lu Yong-Hong Sun Hai-Tao Song Wei-Kang Xu Source Type: research
Involvement of the JNK/HO ‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells
In conclusion, NPs could induce inflammatory responses and ferroptosis in BV2 cells. JNK/HO‑1 mediated ferroptosis may serve an important role in the toxicity of microglia induced by NPs. This study provided novel evidence for the toxic effects of NPs and highlighted a theoretical mechanistic basis for safe prevention and treatment of plastic pollution‑induced neurotoxicity.PMID:37264973 | DOI:10.3892/ijmm.2023.5264
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Jiayin Sun Yihua Wang Yilun Du Wanxin Zhang Zuodong Liu Jin Bai Guanqun Cui Zhongjun Du Source Type: research
Impact of serum ‑free media on the expansion and functionality of CD19.CAR T‑cells
Int J Mol Med. 2023 Jul;52(1):58. doi: 10.3892/ijmm.2023.5261. Epub 2023 Jun 2.ABSTRACTFetal bovine serum (FBS) or human serum is widely used in the production of chimeric antigen receptor (CAR) T‑cells. In order to overcome a lot‑to‑lot inconsistency, the use of chemically defined medium that is free of animal-components would be highly desirable. The present study compared three serum‑free media [Prime‑XV™ T Cell CDM, Fujifilm™ (FF), LymphoONE™ T‑Cell Expansion Xeno‑Free Medium, Takara Bio™ (TB) and TCM GMP‑Prototype, CellGenix™ (CG)] to the standard CAR T‑cell medium containing FBS (RCF). Aft...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Franziska Eberhardt Angela H ückelhoven-Krauss Alexander Kunz Genqiao Jiang Tim Sauer Avinoam Reichman Brigitte Neuber Kathrin B öpple Anita Schmitt Carsten M üller-Tidow Michael Schmitt Anna Keib Source Type: research
Retracted TRIM16 suppresses the progression of prostate tumors by inhibiting the Snail signaling pathway
Int J Mol Med. 2023 Jul;52(1):59. doi: 10.3892/ijmm.2023.5262. Epub 2023 Jun 2.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by concerned readers that the western blotting data shown in Figs. 4C and 7B and D, the scratch‑wound assay images shown in Figs. 5A and 6A, and certain of the cell migration and invasion assay data shown in Figs. 5B and 6B were strikingly similar to data that had previously appeared in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Li Qi Zhong Lu Yong-Hong Sun Hai-Tao Song Wei-Kang Xu Source Type: research
Interaction between apical periodontitis and systemic disease (Review)
Int J Mol Med. 2023 Jul;52(1):60. doi: 10.3892/ijmm.2023.5263. Epub 2023 Jun 2.ABSTRACTApical periodontitis is an oral common inflammatory disease initiated by infection of pulp chamber and is characterized by destruction and resorption of the periapical bone. As a local infection, pathogens and their products in periapical tissues, as well as inflammatory cytokines produced in periapical lesions, enter the blood circulation, triggering systemic immune responses and leading to the pathogenesis of various types of systemic disease. Therefore, apical periodontitis might be associated with systemic disease rather than solely ...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Lanxiang Ye Li Cao Wencheng Song Chen Yang Qingming Tang Zhenglin Yuan Source Type: research
Involvement of the JNK/HO ‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells
In conclusion, NPs could induce inflammatory responses and ferroptosis in BV2 cells. JNK/HO‑1 mediated ferroptosis may serve an important role in the toxicity of microglia induced by NPs. This study provided novel evidence for the toxic effects of NPs and highlighted a theoretical mechanistic basis for safe prevention and treatment of plastic pollution‑induced neurotoxicity.PMID:37264973 | DOI:10.3892/ijmm.2023.5264
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Jiayin Sun Yihua Wang Yilun Du Wanxin Zhang Zuodong Liu Jin Bai Guanqun Cui Zhongjun Du Source Type: research
Impact of serum ‑free media on the expansion and functionality of CD19.CAR T‑cells
Int J Mol Med. 2023 Jul;52(1):58. doi: 10.3892/ijmm.2023.5261. Epub 2023 Jun 2.ABSTRACTFetal bovine serum (FBS) or human serum is widely used in the production of chimeric antigen receptor (CAR) T‑cells. In order to overcome a lot‑to‑lot inconsistency, the use of chemically defined medium that is free of animal-components would be highly desirable. The present study compared three serum‑free media [Prime‑XV™ T Cell CDM, Fujifilm™ (FF), LymphoONE™ T‑Cell Expansion Xeno‑Free Medium, Takara Bio™ (TB) and TCM GMP‑Prototype, CellGenix™ (CG)] to the standard CAR T‑cell medium containing FBS (RCF). Aft...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Franziska Eberhardt Angela H ückelhoven-Krauss Alexander Kunz Genqiao Jiang Tim Sauer Avinoam Reichman Brigitte Neuber Kathrin B öpple Anita Schmitt Carsten M üller-Tidow Michael Schmitt Anna Keib Source Type: research
Retracted TRIM16 suppresses the progression of prostate tumors by inhibiting the Snail signaling pathway
Int J Mol Med. 2023 Jul;52(1):59. doi: 10.3892/ijmm.2023.5262. Epub 2023 Jun 2.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by concerned readers that the western blotting data shown in Figs. 4C and 7B and D, the scratch‑wound assay images shown in Figs. 5A and 6A, and certain of the cell migration and invasion assay data shown in Figs. 5B and 6B were strikingly similar to data that had previously appeared in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Li Qi Zhong Lu Yong-Hong Sun Hai-Tao Song Wei-Kang Xu Source Type: research
Interaction between apical periodontitis and systemic disease (Review)
Int J Mol Med. 2023 Jul;52(1):60. doi: 10.3892/ijmm.2023.5263. Epub 2023 Jun 2.ABSTRACTApical periodontitis is an oral common inflammatory disease initiated by infection of pulp chamber and is characterized by destruction and resorption of the periapical bone. As a local infection, pathogens and their products in periapical tissues, as well as inflammatory cytokines produced in periapical lesions, enter the blood circulation, triggering systemic immune responses and leading to the pathogenesis of various types of systemic disease. Therefore, apical periodontitis might be associated with systemic disease rather than solely ...
Source: International Journal of Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Lanxiang Ye Li Cao Wencheng Song Chen Yang Qingming Tang Zhenglin Yuan Source Type: research
