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Source: International Journal of Molecular Medicine
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Total 2185 results found since Jan 2013.
Role and mechanisms of noncoding RNAs in the regulation of metabolic reprogramming in bladder cancer (Review)
Int J Mol Med. 2023 Sep;52(3):79. doi: 10.3892/ijmm.2023.5282. Epub 2023 Jul 21.ABSTRACTBladder cancer (BLCA) is the most common type of urothelial cancer. The role of metabolic reprogramming in tumors is gradually gaining more attention and being investigated. Recent studies have shown that noncoding RNAs (ncRNAs) are strongly related to BLCA metabolic reprogramming. ncRNAs are able to directly regulate the expression and function of metabolic enzymes, or indirectly regulate them through a number of important pathways to regulate metabolism in BLCA cells. The mechanism of the development of BLCA has not yet, to the best o...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Bin Zhang Liming Yang Yang He Dali Han Peng Qi Panfeng Shang Source Type: research
Nucleolin ‑based targeting strategies in cancer treatment: Focus on cancer immunotherapy (Review)
Int J Mol Med. 2023 Sep;52(3):81. doi: 10.3892/ijmm.2023.5284. Epub 2023 Jul 21.ABSTRACTThe benefits of treating several types of cancers using immunotherapy have recently been established. The overexpression of nucleolin (NCL) in a number of types of cancer provides an attractive antigen target for the development of novel anticancer immunotherapeutic treatments. NCL is a multifunctional protein abundantly distributed in the nucleus, cytoplasm and cell membrane. It influences carcinogenesis, and the proliferation, survival and metastasis of cancer cells, leading to cancer progression. Additionally, the meta‑analysis of ...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Suyanee Thongchot Krittaya Aksonnam Peti Thuwajit Pa-Thai Yenchitsomanus Chanitra Thuwajit Source Type: research
Effects of Sulforaphane on SARS ‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 'cytokine storm'
Int J Mol Med. 2023 Sep;52(3):76. doi: 10.3892/ijmm.2023.5279. Epub 2023 Jul 21.ABSTRACTSince its spread at the beginning of 2020, the coronavirus disease 2019 (COVID‑19) pandemic represents one of the major health problems. Despite the approval, testing, and worldwide distribution of anti‑severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) vaccines, the development of specific antiviral agents targeting the SARS‑CoV‑2 life cycle with high efficiency, and/or interfering with the associated 'cytokine storm', is highly required. A recent study, conducted by the authors' group indicated that sulforaphane ...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Jessica Gasparello Giovanni Marzaro Chiara Papi Valentina Gentili Roberta Rizzo Matteo Zurlo Chiara Scapoli Alessia Finotti Roberto Gambari Source Type: research
Corrigendum A potential therapeutic effect of CYP2C8 overexpression on anti ‑TNF‑α activity
Int J Mol Med. 2023 Sep;52(3):77. doi: 10.3892/ijmm.2023.5280. Epub 2023 Jul 21.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the cell migration assay experiments shown in Fig. 5 on p. 731, the 'TNF‑α' data panels in Fig. 5A and C appeared to be matching, where experiments performed under different conditions were intended to have been displayed. After having re‑examined their original data, the authors have realized that the data files were mislabelled, although they were able to retrieve the correct data for Fig. 5C (where the error occurred). T...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Wanjun Liu Bei Wang Hu Ding Dao Wen Wang Hesong Zeng Source Type: research
Sophoricoside attenuates autoimmune ‑mediated liver injury through the regulation of oxidative stress and the NF‑κB signaling pathway
Int J Mol Med. 2023 Sep;52(3):78. doi: 10.3892/ijmm.2023.5281. Epub 2023 Jul 21.ABSTRACTThe prevalence of autoimmune hepatitis (AIH) is increasing, yet specific pharmacotherapies remain to be explored. The present study aimed to investigate the effects of sophoricoside (SOP), a bioactive component of medical herbs, on AIH and to elucidate the underlying mechanisms. Bioinformatic approaches were used to predict the potential targets and underlying regulatory mechanisms of SOP on AIH. The effects of SOP on AIH were evaluated by determining the expression levels of inflammatory cytokines, histological liver injury and hepatic...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Yu Chen Yu Lei Han Wang Lijia Wang Jiaxin Xu Shuhui Wang Meiping Yu Zhangqi Peng Fang Xiao Dean Tian Mei Liu Source Type: research
HER3/Akt/mTOR pathway is a key therapeutic target for the reduction of triple ‑negative breast cancer metastasis via the inhibition of CXCR4 expression
Int J Mol Med. 2023 Sep;52(3):80. doi: 10.3892/ijmm.2023.5283. Epub 2023 Jul 21.ABSTRACTTriple‑negative breast cancer (TNBC), a highly metastatic subtype of breast cancer, and it has the worst prognosis among all subtypes of breast cancer. However, no effective systematic therapy is currently available for TNBC metastasis. Therefore, novel therapies targeting the key molecular mechanisms involved in TNBC metastasis are required. The present study examined whether the expression levels of human epidermal growth factor receptor 3 (HER3) were associated with the metastatic phenotype of TNBC, and evaluated the potential of H...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Tomoya Takeda Masanobu Tsubaki Shuji Genno Kenta Tokunaga Remi Tanaka Shozo Nishida Source Type: research
Role and mechanisms of noncoding RNAs in the regulation of metabolic reprogramming in bladder cancer (Review)
Int J Mol Med. 2023 Sep;52(3):79. doi: 10.3892/ijmm.2023.5282. Epub 2023 Jul 21.ABSTRACTBladder cancer (BLCA) is the most common type of urothelial cancer. The role of metabolic reprogramming in tumors is gradually gaining more attention and being investigated. Recent studies have shown that noncoding RNAs (ncRNAs) are strongly related to BLCA metabolic reprogramming. ncRNAs are able to directly regulate the expression and function of metabolic enzymes, or indirectly regulate them through a number of important pathways to regulate metabolism in BLCA cells. The mechanism of the development of BLCA has not yet, to the best o...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Bin Zhang Liming Yang Yang He Dali Han Peng Qi Panfeng Shang Source Type: research
Nucleolin ‑based targeting strategies in cancer treatment: Focus on cancer immunotherapy (Review)
Int J Mol Med. 2023 Sep;52(3):81. doi: 10.3892/ijmm.2023.5284. Epub 2023 Jul 21.ABSTRACTThe benefits of treating several types of cancers using immunotherapy have recently been established. The overexpression of nucleolin (NCL) in a number of types of cancer provides an attractive antigen target for the development of novel anticancer immunotherapeutic treatments. NCL is a multifunctional protein abundantly distributed in the nucleus, cytoplasm and cell membrane. It influences carcinogenesis, and the proliferation, survival and metastasis of cancer cells, leading to cancer progression. Additionally, the meta‑analysis of ...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Suyanee Thongchot Krittaya Aksonnam Peti Thuwajit Pa-Thai Yenchitsomanus Chanitra Thuwajit Source Type: research
Effects of Sulforaphane on SARS ‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 'cytokine storm'
Int J Mol Med. 2023 Sep;52(3):76. doi: 10.3892/ijmm.2023.5279. Epub 2023 Jul 21.ABSTRACTSince its spread at the beginning of 2020, the coronavirus disease 2019 (COVID‑19) pandemic represents one of the major health problems. Despite the approval, testing, and worldwide distribution of anti‑severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) vaccines, the development of specific antiviral agents targeting the SARS‑CoV‑2 life cycle with high efficiency, and/or interfering with the associated 'cytokine storm', is highly required. A recent study, conducted by the authors' group indicated that sulforaphane ...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Jessica Gasparello Giovanni Marzaro Chiara Papi Valentina Gentili Roberta Rizzo Matteo Zurlo Chiara Scapoli Alessia Finotti Roberto Gambari Source Type: research
Corrigendum A potential therapeutic effect of CYP2C8 overexpression on anti ‑TNF‑α activity
Int J Mol Med. 2023 Sep;52(3):77. doi: 10.3892/ijmm.2023.5280. Epub 2023 Jul 21.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the cell migration assay experiments shown in Fig. 5 on p. 731, the 'TNF‑α' data panels in Fig. 5A and C appeared to be matching, where experiments performed under different conditions were intended to have been displayed. After having re‑examined their original data, the authors have realized that the data files were mislabelled, although they were able to retrieve the correct data for Fig. 5C (where the error occurred). T...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Wanjun Liu Bei Wang Hu Ding Dao Wen Wang Hesong Zeng Source Type: research
Sophoricoside attenuates autoimmune ‑mediated liver injury through the regulation of oxidative stress and the NF‑κB signaling pathway
Int J Mol Med. 2023 Sep;52(3):78. doi: 10.3892/ijmm.2023.5281. Epub 2023 Jul 21.ABSTRACTThe prevalence of autoimmune hepatitis (AIH) is increasing, yet specific pharmacotherapies remain to be explored. The present study aimed to investigate the effects of sophoricoside (SOP), a bioactive component of medical herbs, on AIH and to elucidate the underlying mechanisms. Bioinformatic approaches were used to predict the potential targets and underlying regulatory mechanisms of SOP on AIH. The effects of SOP on AIH were evaluated by determining the expression levels of inflammatory cytokines, histological liver injury and hepatic...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Yu Chen Yu Lei Han Wang Lijia Wang Jiaxin Xu Shuhui Wang Meiping Yu Zhangqi Peng Fang Xiao Dean Tian Mei Liu Source Type: research
HER3/Akt/mTOR pathway is a key therapeutic target for the reduction of triple ‑negative breast cancer metastasis via the inhibition of CXCR4 expression
Int J Mol Med. 2023 Sep;52(3):80. doi: 10.3892/ijmm.2023.5283. Epub 2023 Jul 21.ABSTRACTTriple‑negative breast cancer (TNBC), a highly metastatic subtype of breast cancer, and it has the worst prognosis among all subtypes of breast cancer. However, no effective systematic therapy is currently available for TNBC metastasis. Therefore, novel therapies targeting the key molecular mechanisms involved in TNBC metastasis are required. The present study examined whether the expression levels of human epidermal growth factor receptor 3 (HER3) were associated with the metastatic phenotype of TNBC, and evaluated the potential of H...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Tomoya Takeda Masanobu Tsubaki Shuji Genno Kenta Tokunaga Remi Tanaka Shozo Nishida Source Type: research
Role and mechanisms of noncoding RNAs in the regulation of metabolic reprogramming in bladder cancer (Review)
Int J Mol Med. 2023 Sep;52(3):79. doi: 10.3892/ijmm.2023.5282. Epub 2023 Jul 21.ABSTRACTBladder cancer (BLCA) is the most common type of urothelial cancer. The role of metabolic reprogramming in tumors is gradually gaining more attention and being investigated. Recent studies have shown that noncoding RNAs (ncRNAs) are strongly related to BLCA metabolic reprogramming. ncRNAs are able to directly regulate the expression and function of metabolic enzymes, or indirectly regulate them through a number of important pathways to regulate metabolism in BLCA cells. The mechanism of the development of BLCA has not yet, to the best o...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Bin Zhang Liming Yang Yang He Dali Han Peng Qi Panfeng Shang Source Type: research
Nucleolin ‑based targeting strategies in cancer treatment: Focus on cancer immunotherapy (Review)
Int J Mol Med. 2023 Sep;52(3):81. doi: 10.3892/ijmm.2023.5284. Epub 2023 Jul 21.ABSTRACTThe benefits of treating several types of cancers using immunotherapy have recently been established. The overexpression of nucleolin (NCL) in a number of types of cancer provides an attractive antigen target for the development of novel anticancer immunotherapeutic treatments. NCL is a multifunctional protein abundantly distributed in the nucleus, cytoplasm and cell membrane. It influences carcinogenesis, and the proliferation, survival and metastasis of cancer cells, leading to cancer progression. Additionally, the meta‑analysis of ...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Suyanee Thongchot Krittaya Aksonnam Peti Thuwajit Pa-Thai Yenchitsomanus Chanitra Thuwajit Source Type: research
Effects of Sulforaphane on SARS ‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 'cytokine storm'
Int J Mol Med. 2023 Sep;52(3):76. doi: 10.3892/ijmm.2023.5279. Epub 2023 Jul 21.ABSTRACTSince its spread at the beginning of 2020, the coronavirus disease 2019 (COVID‑19) pandemic represents one of the major health problems. Despite the approval, testing, and worldwide distribution of anti‑severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) vaccines, the development of specific antiviral agents targeting the SARS‑CoV‑2 life cycle with high efficiency, and/or interfering with the associated 'cytokine storm', is highly required. A recent study, conducted by the authors' group indicated that sulforaphane ...
Source: International Journal of Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Jessica Gasparello Giovanni Marzaro Chiara Papi Valentina Gentili Roberta Rizzo Matteo Zurlo Chiara Scapoli Alessia Finotti Roberto Gambari Source Type: research
