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Source: International Journal of Molecular Medicine
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Total 2185 results found since Jan 2013.
E74 ‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer
Int J Mol Med. 2023 Sep;52(3):75. doi: 10.3892/ijmm.2023.5278. Epub 2023 Jul 14.ABSTRACTE74‑like ETS transcription factor 5 (ELF5) is known to regulate the specification and differentiation of epithelial cells in the embryonic lung. However, the pathological function of ELF5 in lung cancer has yet to be fully elucidated. In the present study, the expression of ELF5 was found to be significantly higher in lung adenocarcinoma compared with that in corresponding adjacent normal tissues. Subsequently, cell and animal experiments were performed to investigate the role of ELF5 in lung adenocarcinoma cells. The results indicate...
Source: International Journal of Molecular Medicine - July 14, 2023 Category: Molecular Biology Authors: Jing Wen Genggeng Qin Zhaojing Jiang Zixun Lin Ruixin Zhou Hui Dai Zhanfa Xu Weiguo Chen Qiancheng Song Source Type: research
The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review)
Int J Mol Med. 2023 Aug;52(2):73. doi: 10.3892/ijmm.2023.5276. Epub 2023 Jul 14.ABSTRACTLong non‑coding RNAs (lncRNAs) represent a class of versatile molecules that exhibit the potential to regulate gene expression at various levels, namely transcriptional, post‑transcriptional and epigenetic, thereby influencing critical cellular processes such as proliferation, apoptosis, invasion and drug resistance. The lncRNA H19, among the earliest identified within this category, has emerged as a significant participant in the pathogenesis of a multitude of both malignant and benign gynecological diseases. An escalating body of ...
Source: International Journal of Molecular Medicine - July 14, 2023 Category: Molecular Biology Authors: Weijuan Xin Yue Wang Keqin Hua Songping Liu Source Type: research
Corrigendum Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression
Int J Mol Med. 2023 Sep;52(3):74. doi: 10.3892/ijmm.2023.5277. Epub 2023 Jul 14.ABSTRACTFollowing the publication of the above article, the authors have contacted the Editorial Office to explain that they had assembled the cellular morphological images in Fig. 1A on p. 819 incorrectly; essentially, the cell morphology of 2 passages of hBMSCs (centre panel) should have been shown as the data panel for 3 passages of hBMSCs (right-hand panel), and likewise, the cell morphology of 3 passages of hBMSCs should have been shown as the data panel for 2 passages of hBMSCs. The revised version of Fig. 1 is shown below. The authors co...
Source: International Journal of Molecular Medicine - July 14, 2023 Category: Molecular Biology Authors: Qiushi Wei Bin Wang Hailan Hu Chuhai Xie Long Ling Jianliang Gao Yanming Cao Source Type: research
E74 ‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer
Int J Mol Med. 2023 Sep;52(3):75. doi: 10.3892/ijmm.2023.5278. Epub 2023 Jul 14.ABSTRACTE74‑like ETS transcription factor 5 (ELF5) is known to regulate the specification and differentiation of epithelial cells in the embryonic lung. However, the pathological function of ELF5 in lung cancer has yet to be fully elucidated. In the present study, the expression of ELF5 was found to be significantly higher in lung adenocarcinoma compared with that in corresponding adjacent normal tissues. Subsequently, cell and animal experiments were performed to investigate the role of ELF5 in lung adenocarcinoma cells. The results indicate...
Source: International Journal of Molecular Medicine - July 14, 2023 Category: Molecular Biology Authors: Jing Wen Genggeng Qin Zhaojing Jiang Zixun Lin Ruixin Zhou Hui Dai Zhanfa Xu Weiguo Chen Qiancheng Song Source Type: research
The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review)
Int J Mol Med. 2023 Aug;52(2):73. doi: 10.3892/ijmm.2023.5276. Epub 2023 Jul 14.ABSTRACTLong non‑coding RNAs (lncRNAs) represent a class of versatile molecules that exhibit the potential to regulate gene expression at various levels, namely transcriptional, post‑transcriptional and epigenetic, thereby influencing critical cellular processes such as proliferation, apoptosis, invasion and drug resistance. The lncRNA H19, among the earliest identified within this category, has emerged as a significant participant in the pathogenesis of a multitude of both malignant and benign gynecological diseases. An escalating body of ...
Source: International Journal of Molecular Medicine - July 14, 2023 Category: Molecular Biology Authors: Weijuan Xin Yue Wang Keqin Hua Songping Liu Source Type: research
Corrigendum Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression
Int J Mol Med. 2023 Sep;52(3):74. doi: 10.3892/ijmm.2023.5277. Epub 2023 Jul 14.ABSTRACTFollowing the publication of the above article, the authors have contacted the Editorial Office to explain that they had assembled the cellular morphological images in Fig. 1A on p. 819 incorrectly; essentially, the cell morphology of 2 passages of hBMSCs (centre panel) should have been shown as the data panel for 3 passages of hBMSCs (right-hand panel), and likewise, the cell morphology of 3 passages of hBMSCs should have been shown as the data panel for 2 passages of hBMSCs. The revised version of Fig. 1 is shown below. The authors co...
Source: International Journal of Molecular Medicine - July 14, 2023 Category: Molecular Biology Authors: Qiushi Wei Bin Wang Hailan Hu Chuhai Xie Long Ling Jianliang Gao Yanming Cao Source Type: research
Corrigendum Incremental load training improves renal fibrosis by regulating the TGF ‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice
Int J Mol Med. 2023 Aug;52(2):71. doi: 10.3892/ijmm.2023.5274. Epub 2023 Jul 7.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the immunofluorescence staining experiments shown in Fig. 3A on p. 1681, the 'E‑cadherin / YC' and 'E‑cadherin / OC' data panels were overlapping, such that they may have been derived from the same original source; moreover, with the transmission electron microscopic images shown in Fig. 6G on p. 1683, the 'OC' and 'OY' panels were similarly overlapping. After having re‑examined their figures, the authors have realized that...
Source: International Journal of Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Chuncha Bao Zhong Yang Qiyan Cai Qian Li Hongli Li Bin Shu Source Type: research
Epstein ‑Barr virus as a promoter of tumorigenesis in the tumor microenvironment of breast cancer (Review)
Int J Mol Med. 2023 Aug;52(2):72. doi: 10.3892/ijmm.2023.5275. Epub 2023 Jul 7.ABSTRACTEpstein‑Barr virus (EBV) is an oncovirus associated with various neoplasms, including breast cancer (BC). EBV‑associated oncogenesis requires the action of several viral molecules, such as EBV nuclear antigen 3C, latent membrane protein 1, microRNAs and long non‑coding RNAs, which are able of manipulating the cellular machinery, inducing an evasion of the immune system, blocking apoptosis processes, promoting cell survival and metastasis. The risk of developing cancer is associated with epigenetic alterations and alterations in var...
Source: International Journal of Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Jos é Damián Gómez-Archila Jos é Arellano-Galindo Carmen Palacios-Reyes Ana Mar ía Espinosa-García Patricia Garc ía Alonso-Themann Juan Xicohtencatl-Cortes Sara A Ochoa Ariadnna Cruz-C órdova Icela Palma-Lara Source Type: research
Corrigendum Incremental load training improves renal fibrosis by regulating the TGF ‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice
Int J Mol Med. 2023 Aug;52(2):71. doi: 10.3892/ijmm.2023.5274. Epub 2023 Jul 7.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the immunofluorescence staining experiments shown in Fig. 3A on p. 1681, the 'E‑cadherin / YC' and 'E‑cadherin / OC' data panels were overlapping, such that they may have been derived from the same original source; moreover, with the transmission electron microscopic images shown in Fig. 6G on p. 1683, the 'OC' and 'OY' panels were similarly overlapping. After having re‑examined their figures, the authors have realized that...
Source: International Journal of Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Chuncha Bao Zhong Yang Qiyan Cai Qian Li Hongli Li Bin Shu Source Type: research
Epstein ‑Barr virus as a promoter of tumorigenesis in the tumor microenvironment of breast cancer (Review)
Int J Mol Med. 2023 Aug;52(2):72. doi: 10.3892/ijmm.2023.5275. Epub 2023 Jul 7.ABSTRACTEpstein‑Barr virus (EBV) is an oncovirus associated with various neoplasms, including breast cancer (BC). EBV‑associated oncogenesis requires the action of several viral molecules, such as EBV nuclear antigen 3C, latent membrane protein 1, microRNAs and long non‑coding RNAs, which are able of manipulating the cellular machinery, inducing an evasion of the immune system, blocking apoptosis processes, promoting cell survival and metastasis. The risk of developing cancer is associated with epigenetic alterations and alterations in var...
Source: International Journal of Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Jos é Damián Gómez-Archila Jos é Arellano-Galindo Carmen Palacios-Reyes Ana Mar ía Espinosa-García Patricia Garc ía Alonso-Themann Juan Xicohtencatl-Cortes Sara A Ochoa Ariadnna Cruz-C órdova Icela Palma-Lara Source Type: research
Corrigendum Incremental load training improves renal fibrosis by regulating the TGF ‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice
Int J Mol Med. 2023 Aug;52(2):71. doi: 10.3892/ijmm.2023.5274. Epub 2023 Jul 7.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the immunofluorescence staining experiments shown in Fig. 3A on p. 1681, the 'E‑cadherin / YC' and 'E‑cadherin / OC' data panels were overlapping, such that they may have been derived from the same original source; moreover, with the transmission electron microscopic images shown in Fig. 6G on p. 1683, the 'OC' and 'OY' panels were similarly overlapping. After having re‑examined their figures, the authors have realized that...
Source: International Journal of Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Chuncha Bao Zhong Yang Qiyan Cai Qian Li Hongli Li Bin Shu Source Type: research
Epstein ‑Barr virus as a promoter of tumorigenesis in the tumor microenvironment of breast cancer (Review)
Int J Mol Med. 2023 Aug;52(2):72. doi: 10.3892/ijmm.2023.5275. Epub 2023 Jul 7.ABSTRACTEpstein‑Barr virus (EBV) is an oncovirus associated with various neoplasms, including breast cancer (BC). EBV‑associated oncogenesis requires the action of several viral molecules, such as EBV nuclear antigen 3C, latent membrane protein 1, microRNAs and long non‑coding RNAs, which are able of manipulating the cellular machinery, inducing an evasion of the immune system, blocking apoptosis processes, promoting cell survival and metastasis. The risk of developing cancer is associated with epigenetic alterations and alterations in var...
Source: International Journal of Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Jos é Damián Gómez-Archila Jos é Arellano-Galindo Carmen Palacios-Reyes Ana Mar ía Espinosa-García Patricia Garc ía Alonso-Themann Juan Xicohtencatl-Cortes Sara A Ochoa Ariadnna Cruz-C órdova Icela Palma-Lara Source Type: research
Corrigendum Incremental load training improves renal fibrosis by regulating the TGF ‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice
Int J Mol Med. 2023 Aug;52(2):71. doi: 10.3892/ijmm.2023.5274. Epub 2023 Jul 7.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the immunofluorescence staining experiments shown in Fig. 3A on p. 1681, the 'E‑cadherin / YC' and 'E‑cadherin / OC' data panels were overlapping, such that they may have been derived from the same original source; moreover, with the transmission electron microscopic images shown in Fig. 6G on p. 1683, the 'OC' and 'OY' panels were similarly overlapping. After having re‑examined their figures, the authors have realized that...
Source: International Journal of Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Chuncha Bao Zhong Yang Qiyan Cai Qian Li Hongli Li Bin Shu Source Type: research
Epstein ‑Barr virus as a promoter of tumorigenesis in the tumor microenvironment of breast cancer (Review)
Int J Mol Med. 2023 Aug;52(2):72. doi: 10.3892/ijmm.2023.5275. Epub 2023 Jul 7.ABSTRACTEpstein‑Barr virus (EBV) is an oncovirus associated with various neoplasms, including breast cancer (BC). EBV‑associated oncogenesis requires the action of several viral molecules, such as EBV nuclear antigen 3C, latent membrane protein 1, microRNAs and long non‑coding RNAs, which are able of manipulating the cellular machinery, inducing an evasion of the immune system, blocking apoptosis processes, promoting cell survival and metastasis. The risk of developing cancer is associated with epigenetic alterations and alterations in var...
Source: International Journal of Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Jos é Damián Gómez-Archila Jos é Arellano-Galindo Carmen Palacios-Reyes Ana Mar ía Espinosa-García Patricia Garc ía Alonso-Themann Juan Xicohtencatl-Cortes Sara A Ochoa Ariadnna Cruz-C órdova Icela Palma-Lara Source Type: research
