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Source: International Journal of Molecular Medicine
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Total 2185 results found since Jan 2013.
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
Characterization of circRNAs in established osimertinib ‑resistant non‑small cell lung cancer cell lines
In conclusion, the present study established osimertinib‑resistant cell lines and revealed that circRNAs may serve as a promising biomarker in NSCLC osimertinib resistance.PMID:37681495 | DOI:10.3892/ijmm.2023.5305
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Xin Chen Jingyao Gu Jiali Huang Kang Wen Ge Zhang Zhenyao Chen Zhaoxia Wang Source Type: research
Corrigendum Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
Int J Mol Med. 2023 Nov;52(5):100. doi: 10.3892/ijmm.2023.5303. Epub 2023 Sep 8.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the western blots shown in Fig. 4 on p. 610, the two leftmost bands shown for the Bax data in Fig. 4A were strikingly similar to the two rightmost Mito Cyt C bands featured in Fig. 4C. The authors have checked their original data, and realized that these data were assembled incorrectly in this figure. The revised version of Fig. 4 is shown below, now featuring the correct Bax data in Fig. 4A. The authors confirm that the errors ...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Jian Du Bo Tang Jingwen Wang Hongtao Sui Xueli Jin Liming Wang Zhongyu Wang Source Type: research
Role of transcription factor FOXM1 in diabetes and its complications (Review)
Int J Mol Med. 2023 Nov;52(5):101. doi: 10.3892/ijmm.2023.5304. Epub 2023 Sep 8.ABSTRACTDiabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biolog...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Baoqing Zhao Mengxi Li Yanting Su Shigang Shan Wenbin Qian Dan Zhu Xiufen Liu Zhenwang Zhang Source Type: research
UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF ‑1α‑mediated mitophagy
Int J Mol Med. 2023 Oct;52(4):99. doi: 10.3892/ijmm.2023.5302. Epub 2023 Sep 8.ABSTRACTStem cell‑based tissue engineering has shown significant potential for rapid restoration of injured cartilage tissues. Stem cells frequently undergo apoptosis because of the prevalence of oxidative stress and inflammation in the microenvironment at the sites of injury. Our previous study demonstrated that stabilization of hypoxia‑inducible factor 1α (HIF‑1α) is key to resisting apoptosis in chondrocytes. Recently, it was reported that Ubiquitin C‑terminal hydrolase L1 (UCHL1) can stabilize HIF‑1α by abrogating the ubiquitina...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qiqian Yan Shanwei Shi Yang Ge Shuangquan Wan Mingfei Li Maoquan Li Source Type: research
Characterization of circRNAs in established osimertinib ‑resistant non‑small cell lung cancer cell lines
In conclusion, the present study established osimertinib‑resistant cell lines and revealed that circRNAs may serve as a promising biomarker in NSCLC osimertinib resistance.PMID:37681495 | DOI:10.3892/ijmm.2023.5305
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Xin Chen Jingyao Gu Jiali Huang Kang Wen Ge Zhang Zhenyao Chen Zhaoxia Wang Source Type: research
Corrigendum Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
Int J Mol Med. 2023 Nov;52(5):100. doi: 10.3892/ijmm.2023.5303. Epub 2023 Sep 8.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the western blots shown in Fig. 4 on p. 610, the two leftmost bands shown for the Bax data in Fig. 4A were strikingly similar to the two rightmost Mito Cyt C bands featured in Fig. 4C. The authors have checked their original data, and realized that these data were assembled incorrectly in this figure. The revised version of Fig. 4 is shown below, now featuring the correct Bax data in Fig. 4A. The authors confirm that the errors ...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Jian Du Bo Tang Jingwen Wang Hongtao Sui Xueli Jin Liming Wang Zhongyu Wang Source Type: research
Role of transcription factor FOXM1 in diabetes and its complications (Review)
Int J Mol Med. 2023 Nov;52(5):101. doi: 10.3892/ijmm.2023.5304. Epub 2023 Sep 8.ABSTRACTDiabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biolog...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Baoqing Zhao Mengxi Li Yanting Su Shigang Shan Wenbin Qian Dan Zhu Xiufen Liu Zhenwang Zhang Source Type: research
UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF ‑1α‑mediated mitophagy
Int J Mol Med. 2023 Oct;52(4):99. doi: 10.3892/ijmm.2023.5302. Epub 2023 Sep 8.ABSTRACTStem cell‑based tissue engineering has shown significant potential for rapid restoration of injured cartilage tissues. Stem cells frequently undergo apoptosis because of the prevalence of oxidative stress and inflammation in the microenvironment at the sites of injury. Our previous study demonstrated that stabilization of hypoxia‑inducible factor 1α (HIF‑1α) is key to resisting apoptosis in chondrocytes. Recently, it was reported that Ubiquitin C‑terminal hydrolase L1 (UCHL1) can stabilize HIF‑1α by abrogating the ubiquitina...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qiqian Yan Shanwei Shi Yang Ge Shuangquan Wan Mingfei Li Maoquan Li Source Type: research
Characterization of circRNAs in established osimertinib ‑resistant non‑small cell lung cancer cell lines
In conclusion, the present study established osimertinib‑resistant cell lines and revealed that circRNAs may serve as a promising biomarker in NSCLC osimertinib resistance.PMID:37681495 | DOI:10.3892/ijmm.2023.5305
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Xin Chen Jingyao Gu Jiali Huang Kang Wen Ge Zhang Zhenyao Chen Zhaoxia Wang Source Type: research
