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Total 12111 results found since Jan 2013.
Ketone Ester Administration Improves Glycemia in Obese Mice
Am J Physiol Cell Physiol. 2023 Aug 14. doi: 10.1152/ajpcell.00300.2023. Online ahead of print.ABSTRACTDuring periods of prolonged fasting/starvation, the liver generates ketones (i.e., β-hydroxybutyrate [βOHB]) that primarily serve as alternative substrates for ATP production. Previous studies have demonstrated that elevations in skeletal muscle ketone oxidation contribute to obesity-related hyperglycemia, whereas inhibition of succinyl CoA:3-ketoacid CoA transferase (SCOT), the rate-limiting enzyme of ketone oxidation, can alleviate obesity-related hyperglycemia. As circulating ketone levels are a key determinant of ke...
Source: Am J Physiol Cell Ph... - August 14, 2023 Category: Cytology Authors: Sayed Amirhossein Tabatabaei Dakhili Kunyan Yang Cassandra A A Locatelli Christina T Saed Amanda A Greenwell Jordan S F Chan Jadin J Chahade Jared Scharff Shahad Al Imarah Farah Eaton Peter A Crawford Keshav Gopal Erin E Mulvihill John R Ussher Source Type: research
Risk of SARS-CoV-2 infection and disease severity among people with bronchiectasis; analysis of three population registries
Chest. 2023 Aug 11:S0012-3692(23)05267-4. doi: 10.1016/j.chest.2023.08.007. Online ahead of print.NO ABSTRACTPMID:37574165 | DOI:10.1016/j.chest.2023.08.007
Source: Chest - August 13, 2023 Category: Respiratory Medicine Authors: Michal Shteinberg Oriol Sibila Nili Stein Rosa Faner Alexander Jordan Nuria Olvera Pradeesh Sivapalan Jens Ulrik S Jensen Megan Crichton Pau Marrades James D Chalmers Christian N Meyer Walid Saliba Source Type: research
ASO Visual Abstract: Patient Experiences Following Aborted Cancer Surgery: A Qualitative Study
Ann Surg Oncol. 2023 Aug 12. doi: 10.1245/s10434-023-14114-x. Online ahead of print.NO ABSTRACTPMID:37573286 | DOI:10.1245/s10434-023-14114-x
Source: Ann Oncol - August 12, 2023 Category: Cancer & Oncology Authors: Lena Stevens Sharla Wells Di-Gregorio Alexandra G Lopez-Aguiar Rakhsha Khatri Aslam Ejaz Timothy M Pawlik Erin Scott Sachin Kale Jordan M Cloyd Source Type: research
ASO Author Reflections: Understanding and Addressing Patient Care Needs after Aborted Cancer Surgery
Ann Surg Oncol. 2023 Aug 12. doi: 10.1245/s10434-023-14101-2. Online ahead of print.NO ABSTRACTPMID:37573283 | DOI:10.1245/s10434-023-14101-2
Source: Ann Oncol - August 12, 2023 Category: Cancer & Oncology Authors: Rakhsha Khatri Jordan M Cloyd Source Type: research
Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape behavior
Sci Adv. 2023 Aug 11;9(32):eadg8869. doi: 10.1126/sciadv.adg8869. Epub 2023 Aug 11.ABSTRACTDopamine is broadly implicated in reinforcement learning, but how patterns of dopamine activity are generated is poorly resolved. Here, we demonstrate that two ion channels, Kv4.3 and BKCa1.1, regulate the pattern of dopamine neuron firing and dopamine release on different time scales to influence separate phases of reinforced behavior in mice. Inactivation of Kv4.3 in VTA dopamine neurons increases ex vivo pacemaker activity and excitability that is associated with increased in vivo firing rate and ramping dynamics before lever pres...
Source: Adv Data - August 11, 2023 Category: Epidemiology Authors: Barbara Juarez Mi-Seon Kong Yong S Jo Jordan E Elum Joshua X Yee Scott Ng-Evans Marcella Cline Avery C Hunker Meagan A Quinlan Madison A Baird Abigail J Elerding Mia Johnson Derek Ban Adriana Mendez Nastacia L Goodwin Marta E Soden Larry S Zweifel Source Type: research
Psychosis in a Patient With Sturge-Weber Syndrome: A Case Report and Literature Review
Prim Care Companion CNS Disord. 2023 Aug 8;25(4):22cr03459. doi: 10.4088/PCC.22cr03459.NO ABSTRACTPMID:37567185 | DOI:10.4088/PCC.22cr03459
Source: Primary Care - August 11, 2023 Category: Primary Care Authors: Stanley Nkemjika Erica Jordan Patrice Fouron Haroon Saeed Tolu Olupona Olaniyi Olayinka Source Type: research
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions
Trends Biochem Sci. 2023 Aug 9:S0968-0004(23)00165-2. doi: 10.1016/j.tibs.2023.07.002. Online ahead of print.ABSTRACTGuanylate-binding proteins (GBPs) are a family of intracellular proteins which have diverse biological functions, including pathogen sensing and host defense against infectious disease. These proteins are expressed in response to interferon (IFN) stimulation and can localize and target intracellular microbes (e.g., bacteria and viruses) by protein trafficking and membrane binding. These properties contribute to the ability of GBPs to induce inflammasome activation, inflammation, and cell death, and to direct...
Source: Trends in Biochemical Sciences - August 11, 2023 Category: Biochemistry Authors: Max Kirkby Daniel Enosi Tuipulotu Shouya Feng Jordan Lo Pilato Si Ming Man Source Type: research
Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape behavior
Sci Adv. 2023 Aug 11;9(32):eadg8869. doi: 10.1126/sciadv.adg8869. Epub 2023 Aug 11.ABSTRACTDopamine is broadly implicated in reinforcement learning, but how patterns of dopamine activity are generated is poorly resolved. Here, we demonstrate that two ion channels, Kv4.3 and BKCa1.1, regulate the pattern of dopamine neuron firing and dopamine release on different time scales to influence separate phases of reinforced behavior in mice. Inactivation of Kv4.3 in VTA dopamine neurons increases ex vivo pacemaker activity and excitability that is associated with increased in vivo firing rate and ramping dynamics before lever pres...
Source: Adv Data - August 11, 2023 Category: Epidemiology Authors: Barbara Juarez Mi-Seon Kong Yong S Jo Jordan E Elum Joshua X Yee Scott Ng-Evans Marcella Cline Avery C Hunker Meagan A Quinlan Madison A Baird Abigail J Elerding Mia Johnson Derek Ban Adriana Mendez Nastacia L Goodwin Marta E Soden Larry S Zweifel Source Type: research
Soluble wild-type ACE2 molecules inhibit newer SARS-CoV-2 variants and are a potential antiviral strategy to mitigate disease severity in COVID-19
Clin Exp Immunol. 2023 Aug 11:uxad096. doi: 10.1093/cei/uxad096. Online ahead of print.ABSTRACTSARS-CoV-2, the virus responsible for COVID-19, has caused havoc around the world. While several COVID-19 vaccines and drugs have been authorised for use, these antiviral drugs remain beyond the reach of most low- and middle-income countries. Rapid viral evolution is reducing the efficacy of vaccines and monoclonal antibodies and contributing to deaths of some fully vaccinated persons. Others with normal immunity may have chosen not be vaccinated and remain at risk if they contract the infection. Vaccines may not protect some imm...
Source: Clinical and Developmental Immunology - August 11, 2023 Category: Allergy & Immunology Authors: Rohan Ameratunga Emily Mears Euphemia Leung Russell Snell See-Tarn Woon William Kelton Natalie Medlicott Anthony Jordan William Abbott Richard Steele William Rolleston Hilary Longhurst Klaus Lehnert Source Type: research
Systematic review of the human health hazards of propylene dichloride
Regul Toxicol Pharmacol. 2023 Aug 8:105468. doi: 10.1016/j.yrtph.2023.105468. Online ahead of print.ABSTRACTPropylene dichloride (PDC) is a chlorinated substance used primarily as an intermediate in basic organic chemical manufacturing. The United States Environmental Protection Agency (EPA) is currently evaluating PDC as a high-priority substance under the Toxic Substances Control Act (TSCA). We conducted a systematic review of the non-cancer and cancer hazards of PDC using the EPA TSCA and Integrated Risk Information System (IRIS) frameworks. We identified 11 epidemiological, 16 toxicokinetic, 34 experimental animal, and...
Source: Cancer Control - August 10, 2023 Category: Cancer & Oncology Authors: Heather N Lynch Jordan S Kozal Melissa J Vincent Rachel D Freid Evan A Beckett Sarah Brown Claire Mathis Rita S Schoeny Andrew Maier Source Type: research
