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Real-world data on induction therapy in patients with transplant-ineligible newly diagnosed multiple myeloma: retrospective analysis of 598 cases from Kansai Myeloma Forum
Int J Hematol. 2023 Sep 5. doi: 10.1007/s12185-023-03653-4. Online ahead of print.ABSTRACTTo investigate the real-world clinical outcomes and management of novel drug-containing therapies for newly diagnosed multiple myeloma (MM) patients, we retrospectively analyzed data on the first-line treatment for newly diagnosed transplant-ineligible MM patients from Kansai Myeloma Forum, a registry network in Japan. A total of 598 patients treated with novel drugs between March 2007 and February 2018 were analyzed. Regimens used were VD (n = 305), Rd (n = 103), VMP (n = 97), VCD (n = 71), and VRd (n = 22). Younger patients tended t...
Source: International Journal of Hematology - September 5, 2023 Category: Hematology Authors: Yuji Shimura Hirohiko Shibayama Aya Nakaya Ryosuke Yamamura Kazunori Imada Hitomi Kaneko Hitoshi Hanamoto Shin-Ichi Fuchida Hirokazu Tanaka Satoru Kosugi Miki Kiyota Toshimitsu Matsui Junya Kanda Masato Iida Mitsuhiro Matsuda Nobuhiko Uoshima Masaru Shiba Source Type: research
Safety, pharmacokinetics, and efficacy of belantamab mafodotin monotherapy in Japanese patients with relapsed or refractory multiple myeloma: DREAMM-11
Int J Hematol. 2023 Sep 5. doi: 10.1007/s12185-023-03652-5. Online ahead of print.ABSTRACTBelantamab mafodotin, a B-cell maturation antigen-targeting antibody-drug conjugate (ADC), was investigated in Japanese patients with relapsed/refractory multiple myeloma in Part 1 of the phase I DREAMM-11 study. Patients who had received ≥ 2 prior lines of therapy including a proteasome inhibitor and immunomodulatory agent were eligible. Eight patients received belantamab mafodotin monotherapy at 2.5 mg/kg (n = 4) or 3.4 mg/kg (n = 4) by intravenous infusion every 3 weeks on day 1 of each cycle until disease progression or unaccept...
Source: International Journal of Hematology - September 5, 2023 Category: Hematology Authors: Shinsuke Iida Kazutaka Sunami Yuko Mishima Taku Fujii Hitomi Kato Takumi Terao Yuki Matsuzawa Mari Matsubara Timothy Crossman Brandon E Kremer Ira Gupta Source Type: research
Current status of the educational environment to acquire and maintain the professional skills of radiotherapy technology and medical physics specialists in Japan: a nationwide survey
This study aimed to investigate the educational environment of radiotherapy technology and medical physics specialists (RTMP) in Japan. We conducted a nationwide questionnaire survey in radiotherapy institutions between June and August 2022. Participants were asked questions regarding the educational system, perspectives on updating RTMP's skills and qualifications, and perspectives on higher education for RTMP at radiotherapy institutions. The results were then analyzed in detail according to three factors: whether the hospital was designed for cancer care, whether it was a Japanese Society for Radiation Oncology (JASTRO)...
Source: Health Physics - September 5, 2023 Category: Physics Authors: Naoki Hayashi Masahiko Okumura Mitsuhiro Nakamura Yoshitomo Ishihara Seiichi Ota Naoki Tohyama Kohei Shimomura Hiroyuki Okamoto Hiroshi Onishi Source Type: research
Real-world data on induction therapy in patients with transplant-ineligible newly diagnosed multiple myeloma: retrospective analysis of 598 cases from Kansai Myeloma Forum
Int J Hematol. 2023 Sep 5. doi: 10.1007/s12185-023-03653-4. Online ahead of print.ABSTRACTTo investigate the real-world clinical outcomes and management of novel drug-containing therapies for newly diagnosed multiple myeloma (MM) patients, we retrospectively analyzed data on the first-line treatment for newly diagnosed transplant-ineligible MM patients from Kansai Myeloma Forum, a registry network in Japan. A total of 598 patients treated with novel drugs between March 2007 and February 2018 were analyzed. Regimens used were VD (n = 305), Rd (n = 103), VMP (n = 97), VCD (n = 71), and VRd (n = 22). Younger patients tended t...
Source: International Journal of Hematology - September 5, 2023 Category: Hematology Authors: Yuji Shimura Hirohiko Shibayama Aya Nakaya Ryosuke Yamamura Kazunori Imada Hitomi Kaneko Hitoshi Hanamoto Shin-Ichi Fuchida Hirokazu Tanaka Satoru Kosugi Miki Kiyota Toshimitsu Matsui Junya Kanda Masato Iida Mitsuhiro Matsuda Nobuhiko Uoshima Masaru Shiba Source Type: research
Safety, pharmacokinetics, and efficacy of belantamab mafodotin monotherapy in Japanese patients with relapsed or refractory multiple myeloma: DREAMM-11
Int J Hematol. 2023 Sep 5. doi: 10.1007/s12185-023-03652-5. Online ahead of print.ABSTRACTBelantamab mafodotin, a B-cell maturation antigen-targeting antibody-drug conjugate (ADC), was investigated in Japanese patients with relapsed/refractory multiple myeloma in Part 1 of the phase I DREAMM-11 study. Patients who had received ≥ 2 prior lines of therapy including a proteasome inhibitor and immunomodulatory agent were eligible. Eight patients received belantamab mafodotin monotherapy at 2.5 mg/kg (n = 4) or 3.4 mg/kg (n = 4) by intravenous infusion every 3 weeks on day 1 of each cycle until disease progression or unaccept...
Source: International Journal of Hematology - September 5, 2023 Category: Hematology Authors: Shinsuke Iida Kazutaka Sunami Yuko Mishima Taku Fujii Hitomi Kato Takumi Terao Yuki Matsuzawa Mari Matsubara Timothy Crossman Brandon E Kremer Ira Gupta Source Type: research
Electrochemical determination of ethylvanillin based on LaV@GAC nanocomposite
Anal Sci. 2023 Sep 5. doi: 10.1007/s44211-023-00422-5. Online ahead of print.ABSTRACTEthyl vanillin (EVA) is widely used as a flavor additive in foods, and sensitive monitoring of EVA is of great significance for food safety. In this paper, the biomass of gum arabic derived carbon (GAC) coated with lanthanum vanadate (LaV) was constructed for the EVA sensor based on the synergistic effects of the electrochemical catalytic ability of LaV, the enhanced electrical conductivity with the GAC coating and the oxygen-containing functional groups in LaV@GAC. The as-developed LaV@GAC sensor showed a remarkable linear range from 0.06...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 5, 2023 Category: Chemistry Authors: Haijun Du Yu Duan Jixing Ai Dabin Kong Dexiang Wang Huali Hu Hong Wang Yang Yang Source Type: research
Analysis of polyisoprene oligomers via in situ silver nanoparticle formation on thin-layer chromatography plate using matrix-assisted laser-induced desorption/ionization mass spectrometry
Anal Sci. 2023 Sep 5. doi: 10.1007/s44211-023-00420-7. Online ahead of print.ABSTRACTThe direct mass spectrometry (MS) detection of polyisoprene (PI) oligomers on a thin-layer chromatography (TLC) plate using matrix-assisted laser-induced desorption/ionization (MALDI) with silver trifluoroacetate as the cationization reagent was investigated. The spots of PI oligomers and silver trifluoroacetate on the TLC plate resulted in brown materials after UV laser irradiation. It was suggested that silver trifluoroacetate yielded Ag nanoparticles as brown materials after heating via laser irradiation. The nanoparticles behaved as an...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 5, 2023 Category: Chemistry Authors: Ryota Irifune Takanao Ishikawa Shinya Kitagawa Yoshinori Iiguni Hajime Ohtani Source Type: research
Outcomes of Pain Management Training for the Fourth- and Fifth-Year Medical Students
In this study, we assessed students' understanding of pain management based on the results of pretests and posttests performed before and after their practicum. These tests were administered from November 2019 to April 2022 to 263 fourth- and fifth-year medical students who took the clinical pain study class. The test results were compared in terms of the percentage of correct answers and the total score for each question using McNemar's chi-square test and paired t-tests, respectively. The results showed a significant improvement in the mean of the total score, confirming the improvement in medical students' knowledge (6....
Source: Pain Research and Management - September 4, 2023 Category: Anesthesiology Authors: Ayano Saeki Yumiko Takao Keiichiro Suzuki Munetaka Hirose Source Type: research
Descriptive Study on a Nationwide Exploratory Questionnaire Survey of Emergency Contraceptive Pills and Their Sexual History and Knowledge in Japan
This study showed that approximately half of participants may not have correct knowledge of emergency contraceptives. In addition, approximately half of sexually active participants are facing unintended pregnancies due to a lack of sexual and reproductive awareness. Hence, comprehensive sex education is necessary to achieve social and regulatory changes centered on emergency contraceptives.PMID:37661409 | DOI:10.1248/bpb.b23-00268
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Kenji Momo Erika Maeda Haruka Hattori Haruka Isozaki Hiroko Takita Hokuto Morohoshi Kakei Ryu Noriko Hida Takehiko Sambe Nahoko Shirato Source Type: research
Comparison of the Speed of Enrollment for Clinical Trials Conducted by Japanese and Global Pharmaceutical Companies
In this study, we examined the speed of enrollment period in clinical trials. We surveyed clinical trials from January 1, 2010, to December 31, 2019, covering the top 10 pharmaceutical companies in each global sales ranking (Global 10) and the Japanese sales ranking (Japan 10). Clinical trial data were obtained from ClinicalTrials.gov, a clinical trial registration information database, and the speed of participant enrollment (cases/month) was compared for each phase of the trials. The number of clinical trials conducted during the 10 years was 8938 trials for Global 10 and 1439 trials for Japan 10. Comparing the speed of ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Hideki Maeda Moeka Yamanoi Yuka Fukuda Yuina Inaba Source Type: research
Assessment of Diagnosis Timing of Attention-Deficit/Hyperactivity Disorder in Working-Age Workers with Psychiatric Diseases Using Large Claims Data
This study aims to clarify the timing of diagnosis of ADHD in working-age workers with psychiatric comorbidities using large claims data in Japan. Based on a literature survey, we identified 10 typical comorbidities of ADHD. Among 3064162 participants with social insurance, 215060 working-age workers who were diagnosed with the 10 typical comorbidities of ADHD were included. Cohort 1 consisted of 96994 patients with the index date set as the earliest date of diagnosis of a comorbidity within the 12-month screening and 12-month observation periods. In cohort 2, 107436 patients were included, and the first date of diagnosis ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Mutsumi Ando Kenji Momo Noriko Hida Taigi Yamazaki Iori Taki Tsutomu Nagai Takashi Yoshio Masahiro Kurosawa Source Type: research
Effect of a Family Pharmacist System on Medication Adherence of Patients with Dyslipidemia during a COVID-19 Epidemic
In this study, using anonymously processed receipt data from 700 insurance pharmacies in our group, we evaluated medication adherence in patients taking statin drugs before, during the first and second years of coronavirus disease 2019 (COVID-19) epidemic in terms of medication persistence and medication possession, and compared the results between the family pharmacist group (FP group) and non-family pharmacist group (NoFP group). The odds ratios of good medication adherence (medication persistence and medication possession) rates for the FP group relative to the NoFP group were 1.446 [95% confidence interval (CI): 1.210-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Mamoru Maeda Yoshitaka Hasegawa Ryota Tsukioka Miya Oishi Source Type: research
Reduction in Patient Waiting Times in Pharmacies by a Protocol to Minimize Inquiries to Doctors under an Agreement between a Hospital and Community Pharmacies
In conclusion, introduction of a protocol aimed at minimizing inquiries about prescriptions to doctors from a community pharmacy was useful in reducing the waiting time of patients, and also likely in decreasing the working times of medical doctors and pharmacists.PMID:37661441 | DOI:10.1248/yakushi.23-00021
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Hideaki Hiramatsu Ryo Kobayashi Hironori Fujii Mika Uno Chiho Masuda Syoko Mabuchi Tomoyuki Hirashita Takako Hayashi Kazuhiro Iguchi Hitomi Teramachi Hirokazu Ibuka Tetsuya Ohashi Akio Suzuki Kimio Yasuda Source Type: research
Solubilization of Poorly Water-soluble Drugs with Amphiphilic Phospholipid Polymers
Yakugaku Zasshi. 2023;143(9):745-756. doi: 10.1248/yakushi.23-00023.ABSTRACTMost drug candidates developed in recent years are poorly water-soluble, which is a key challenge in pharmaceutical science. Various solubilization methods have been investigated thus far, most of which require solubilizers that provide a local hydrophobic environment wherein a drug can dissolve or induce interactions with drug molecules. We have focused on amphiphilic 2-methacryloyloxyethyl phosphoryl choline (MPC) polymers. In addition to the ease of molecular design of amphiphilic MPC polymers owing to their chemical structures, they have been r...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Kensuke Yoshie Kazuhiko Ishihara Source Type: research
Cultured Cells in the Aging Research, Exhibiting Cell Surface Component Functions, Intracellular Signaling, a Novel Adaptor Molecule, Aging Phenotype Expression and Various Aspects of the Cellular Physiology
Yakugaku Zasshi. 2023;143(9):729-744. doi: 10.1248/yakushi.23-00017.ABSTRACTCellular aging is one of the most extraordinary phenomena that mammalian cells undergo in vivo and in vitro. We have been observing their behavior for approximately 4 decades and here would like to summarize some of our salient findings. Normal cells such as human diploid cells exhibit finite growth potential in vitro as well as a set of senescent cell phenotypes. Those changes appear probabilistic and irreversible. In the search of the factor(s) to evoke the features we have observed that cellular glycosaminoglycan molecules plays significant role...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Koozi Matuoka Source Type: research
