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Total 127508 results found since Jan 2013.
Recent engineering advances of EVs for compounds, nucleic acids, and TCM delivery
Eur J Pharm Sci. 2023 Sep 15;190:106584. doi: 10.1016/j.ejps.2023.106584. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are phospholipid bilayer nano-vesicles that were originally identified to deliver signals for intercellular communications. Based on the dynamic contents including proteins, nucleic acids and metabolites, EVs have been developed into diagnostic and therapeutic fields including cardiovascular diseases, neurological disorders and infectious diseases. A growing number of investigations revealed that EVs are also powerful carriers of loaded compounds and nucleic acids as enhanced treatments. Here...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Yunfeng Di Wei Wang Yong Wang Jingyu Wang Source Type: research
Genetic diversity and molecular evolution of Seoul virus in Hebei province, China
Infect Genet Evol. 2023 Sep 16;114:105503. doi: 10.1016/j.meegid.2023.105503. Online ahead of print.ABSTRACTSeoul virus (SEOV) is a major pathogen which causes hemorrhagic fever with renal syndrome (HFRS), and is present all over the world. However, there are currently few long-term systematic studies of SEOV's phylogenetic and evolutionary mechanisms in epidemic areas. Thus, in this study, we used RT-PCR combined with NGS to obtain the genomes of six SEOV viruses from 1993, as well as 56 Hebei province-specific tissue samples from 1999 to 2022. Phylogenetic analysis showed that the SEOV samples could be divided into seven...
Source: Infection, Genetics and Evolution - September 17, 2023 Category: Genetics & Stem Cells Authors: Yamei Wei Yanan Cai Xu Han Zhanying Han Yanbo Zhang Yonggang Xu Qi Li Source Type: research
Quantitative Evidence of the effect of Baduanjin exercise on quality of life and cardiac function in adults with chronic heart failure
CONCLUSION: Evidence from the meta-analysis support the beneficial effects of Baduanjin exercise on the QoL, cardiac function, and VO2max in patients with CHFin China. For optimal QoL improvements, it is recommended to engage in Baduanjin exercise 5-7 times per week for 30-60 min, over a duration of at least 8 weeks. In terms of NT-Pro BNP, Baduanjin exercise sessions of 30-60 min, 2-7 times per week, for a minimum of 8 weeks are recommended.PMID:37717550 | DOI:10.1016/j.ctcp.2023.101775
Source: Complementary Therapies in Clinical Practice - September 17, 2023 Category: Complementary Medicine Authors: Bowei Mei Lulu Yuan Yankai Shu Source Type: research
Epidemiological characteristics of centenarian deaths in China during 2013-2020: A trend and subnational analysis
CONCLUSIONS: Unlike other countries, centenarian deaths in China are characterized by a higher proportion of home and heart disease deaths, and this death pattern differs across provinces.PMID:37718285 | DOI:10.1097/CM9.0000000000002823
Source: Chinese Medical Journal - September 17, 2023 Category: General Medicine Authors: Fan Mao Weiwei Zhang Peng Yin Lijun Wang Jinling You Jiangmei Liu Yunning Liu Maigeng Zhou Source Type: research
Prognostic and clinical value of circPRKCI expression in diverse human cancers
CONCLUSION: Elevated circPRKCI expression was correlated with worse OS and unfavorable clinical features, suggesting a novel prognostic and predictive role of circPRKCI in diverse human cancers.PMID:37718264 | DOI:10.1097/CM9.0000000000002844
Source: Chinese Medical Journal - September 17, 2023 Category: General Medicine Authors: Zhongyue Liu Xiaolei Ren Zhimin Yang Lin Mei Wenyi Li Chao Tu Zhihong Li Source Type: research
Genetic diversity and molecular evolution of Seoul virus in Hebei province, China
Infect Genet Evol. 2023 Sep 15:105503. doi: 10.1016/j.meegid.2023.105503. Online ahead of print.ABSTRACTSeoul virus (SEOV) is a major pathogen which causes hemorrhagic fever with renal syndrome (HFRS), and is present all over the world. However, there are currently few long-term systematic studies of SEOV's phylogenetic and evolutionary mechanisms in epidemic areas. Thus, in this study, we used RT-PCR combined with NGS to obtain the genomes of six SEOV viruses from 1993, as well as 56 Hebei province-specific tissue samples from 1999 to 2022. Phylogenetic analysis showed that the SEOV samples could be divided into seven gro...
Source: Infection, Genetics and Evolution - September 17, 2023 Category: Genetics & Stem Cells Authors: Yamei Wei Yanan Cai Xu Han Zhanying Han Yanbo Zhang Yonggang Xu Qi Li Source Type: research
Recent engineering advances of EVs for compounds, nucleic acids, and TCM delivery
Eur J Pharm Sci. 2023 Sep 15:106584. doi: 10.1016/j.ejps.2023.106584. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are phospholipid bilayer nano-vesicles that were originally identified to deliver signals for intercellular communications. Based on the dynamic contents including proteins, nucleic acids and metabolites, EVs have been developed into diagnostic and therapeutic fields including cardiovascular diseases, neurological disorders and infectious diseases. A growing number of investigations revealed that EVs are also powerful carriers of loaded compounds and nucleic acids as enhanced treatments. Herein, ...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Yunfeng Di Wei Wang Yong Wang Jingyu Wang Source Type: research
Epidemiological characteristics of centenarian deaths in China during 2013-2020: A trend and subnational analysis
CONCLUSIONS: Unlike other countries, centenarian deaths in China are characterized by a higher proportion of home and heart disease deaths, and this death pattern differs across provinces.PMID:37718285 | DOI:10.1097/CM9.0000000000002823
Source: Chinese Medical Journal - September 17, 2023 Category: General Medicine Authors: Fan Mao Weiwei Zhang Peng Yin Lijun Wang Jinling You Jiangmei Liu Yunning Liu Maigeng Zhou Source Type: research
Prognostic and clinical value of circPRKCI expression in diverse human cancers
CONCLUSION: Elevated circPRKCI expression was correlated with worse OS and unfavorable clinical features, suggesting a novel prognostic and predictive role of circPRKCI in diverse human cancers.PMID:37718264 | DOI:10.1097/CM9.0000000000002844
Source: Chinese Medical Journal - September 17, 2023 Category: General Medicine Authors: Zhongyue Liu Xiaolei Ren Zhimin Yang Lin Mei Wenyi Li Chao Tu Zhihong Li Source Type: research
Zhizi-Chuanxiong herb pair alleviates atherosclerosis progression in ApoE < sup > -/- < /sup > mice by promoting the methylation of FGFR3 to inhibit MAPK/ERK-mediated apoptosis
CONCLUSION: Our findings suggest that ZCHP can effectively attenuate AS progression by inhibiting MAPK/ERK signaling-mediated apoptosis via FGFR3 hypermethylation in the promoter region.PMID:37716492 | DOI:10.1016/j.jep.2023.117188
Source: Atherosclerosis - September 16, 2023 Category: Cardiology Authors: Yan Zhang Dandan Li Zijun Jia Jun Mei Ya Wang Ying Zhang Qingbing Zhou Fengqin Xu Source Type: research
Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors
CONCLUSION: In this study, we have explored luteolin as one of the active components of YQG, and may inhibit the proliferation and migration of A549 cells by decreasing the expression of AR and the regulation of phosphorylation at AR-binding sites.PMID:37716981 | DOI:10.1186/s40001-023-01302-4
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Xu Li Yeling Tang Pengchen Liang Miaomiao Sun Tian Li Zhiping Shen Shuang Sha Source Type: research
Genetic polymorphisms of rs73620203 in the transforming growth interacting factor gene associated with rheumatoid arthritis in a Chinese population
CONCLUSION: Our study provides the first evidence that rs73620203 is associated with RA susceptibility and the relationship between TGIF gene SNPs and the regulation of bone metabolism in RA patients.PMID:37716127 | DOI:10.1016/j.imbio.2023.152741
Source: Immunobiology - September 16, 2023 Category: Allergy & Immunology Authors: Huiling Tan Ruyu Ren Xuean Wang Wenchuang Hu Bin Yang Source Type: research
Cloning and deorphanization of three inotocin (insect oxytocin/vasopressin-like) receptors and their ligand from the tick Ixodes scapularis
Biochem Biophys Res Commun. 2023 Sep 9;680:34-41. doi: 10.1016/j.bbrc.2023.09.009. Online ahead of print.ABSTRACTMany insects produce the cyclic neuropeptide inotocin (CLITNCPRGamide), which is the insect orthologue of the mammalian neuropeptides oxytocin and vasopressin. These insects also have one inotocin G protein-coupled receptor (GPCR), which is the orthologue of the mammalian oxytocin and vasopressin receptors. The tick Ixodes scapularis belongs to the subphylum Chelicerata, an arthropod taxon different from insects, to which also spiders, scorpions, and mites belong. I. scapularis is an ectoparasite and a health ri...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Frank Hauser Tara Al-Ribaty Marisa Stebegg Gedske Thygesen Cornelis J P Grimmelikhuijzen Source Type: research
Anti-oxidant, diabetic and inflammatory activities of alpinia calcarata roscoe extract
CONCLUSION: Our findings demonstrated that leaf oil was slightly more promising results than rhizome oil of AC extract,which was ultimately showed medicinal potential of secondary metabolites with antioxidant, diabetic/inflammatory activities. Further, Eoils of AC have a wide range of pharmacological potential and promising anti-diabetic effects.PMID:37715949 | DOI:10.1002/cbdv.202300970
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Naorem Manglembi Devi Sankaranarayanan Nagarajan Chingakham Brajakishor Singh Mohammad Mujahid Ali Khan Anish Khan Nisha Khan Mohamed H Mahmoud Hassan Fouad AbuZar Ansari Source Type: research
